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Characterization of drug penetration to the brain for preventing development of symptoms and progress of the aging disease

Research Project

Project/Area Number 22590149
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionNihon University

Principal Investigator

SUZUKI Toyofumi  日本大学, 薬学部, 准教授 (20267115)

Co-Investigator(Kenkyū-buntansha) FUKAMI Toshiro  日本大学, 薬学部, 准教授 (20366628)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアルツハイマー病 / パーキンソン病 / 脳内移行性 / アンチエイジング / クレアチニン / 薬学 / 血液脳関門 / アマンタジン / クルクミン / レボドパ
Research Abstract

This study characterized penetration of several drugs to the brain for preventing development of symptoms and progress of the aging disease. (1) Curcumin permeation into bovine brain microvascular endothelial cells could not determine with limitation of detection in HPLC-UV method. (2) Transport of [3^H]fluvastatin into bovine brain microvascular endothelial cells was involved in the carrier-mediated mechanism. (3) Transport of [3^H]amantadine into rat brain microvascular endothelial cells was involved in the organic cation-sensitive transport system. About 50% of amantadine decreased comparatively slowly in 60 minutes after the microinject in a rat cerebrum. (4) It was suggested that the transporter intervention transport efficiency of levodopa decreases slightly in Parkinson's disease. (5) Participation of a simple diffusion mechanism and P-glycoprotein in the transport of mazindol at the blood-brain barrier, and (6) no influences of P-glycoprotein at the blood-brain barrier transport of amantadine, were demonstrated from experiments using human brain microvascular endothelium cells or the brain perfusion technique. (7) Serum creatinine (SCr) increased significantly following sulfamethoxazole-trimethoprim (SMX-TMP) combination product use in patients ?74 years of age and ?75 years of age, in both males and females, and in patients with a total dose of ?8 g (8 to 96 g) (P<0.05). The group with a total dose of ?8 g (mean 29.8 g) had a significant SCr increase of 18.4% (P=0.002), while the increase in the ?7 g (mean 5.3 g) group was only 4.5%. The data showed that SCr increased byabout 20% when the total dose taken over the treatment period was around 30 g (about2.4 g as TMP) and indicated that total dose contributes more than age and sex to the post-treatment increase in SCr.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (8 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Factors Contributing to Increases in Serum Creatinine Following Treatment with a Sulfamethoxazole-trimethoprim Combination Product: Retrospective Analysis of Japanese Patients with Normal Renal Function2013

    • Author(s)
      宗村盛,鈴木豊史,高野賢児,島田侯陛,井上真由美,川井龍美,深水啓朗,伴野和夫
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 133 Issue: 5 Pages: 587-595

    • DOI

      10.1248/yakushi.12-00273

    • NAID

      130003361939

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2013-05-01
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] スルファメトキサゾール/トリメトプリム配合剤の投与による血清クレアチニンの上昇とその要因:正常な腎機能を有する日本人患者を対象とした遡及的解析2013

    • Author(s)
      宗 村盛,鈴木豊史,他6名
    • Journal Title

      薬学雑誌

      Volume: 133

    • NAID

      130003361939

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経系薬の創薬開発における血液脳関門透過の重要性2012

    • Author(s)
      鈴木豊史
    • Journal Title

      ファルマシア

      Volume: 48 Pages: 761-766

    • NAID

      110009901151

    • URL

      http://ci.nii.ac.jp/naid/10030986531

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Antagonism of NMDA receptors by butanesulfonyl-homospermine guanidine and nouroprotective effects in in vitro and in vivo2012

    • Author(s)
      Takashi Masuko, Toyofumi Suzuki, et al
    • Journal Title

      Neuroscience Letters

      Volume: 506 Issue: 2 Pages: 251-255

    • DOI

      10.1016/j.neulet.2011.11.017

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT([○!R]) EPO2012

    • Author(s)
      T.Kojima, K.Higashi, T.Suzuki, K.Tomono, K.Moribe, K. Yamamoto
    • Journal Title

      Pharm Res

      Volume: (印刷中) Issue: 10 Pages: 2777-2791

    • DOI

      10.1007/s11095-011-0655-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood-Brain Barrier Transport of Opioid Analgesics2011

    • Author(s)
      鈴木豊史
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 131 Issue: 10 Pages: 1445-1451

    • DOI

      10.1248/yakushi.131.1445

    • NAID

      130001246164

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2011-10-01
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of1,8-Cineole on the Percutaneous Absorption of Lomerizine Dihydrochloride[626]2012

    • Author(s)
      Takayuki Furuishi, Yukiko Kato, Toshiro Fukami, Toyofumi Suzuki, Haruhisa Ueda, Kazuo Tomono
    • Organizer
      The 39th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Quebec City (Canada).
    • Year and Date
      2012-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] スルファメトキサゾール/トリメトプリム配合剤の投与による血清クレアチニンの上昇とその要因[29amF-359]2012

    • Author(s)
      鈴木豊史,宗村盛,高野賢児,島田侯陛,井上真由美,川井龍美,深水啓朗,伴野和夫
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Blood-Brain Barrier Transport of an Essential Amino Acid after Cerebral Ischemia Reperfusion Injury[P01-01]2011

    • Author(s)
      Toyofumi Suzuki, Yumiko Miyazaki, Aya Ohmuro, Masaki Watanabe, Takayuki Furuishi, Toshiro Fukami, Kazuo Tomono
    • Organizer
      The XVth International Symposium of Brain Edema and Cellular Injury (BrainEdema 2011)
    • Place of Presentation
      東京
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Blood-Brain Barrier Transport of an Essential Amino Acid after Cerebral Ischemia Reperfusion Injury2011

    • Author(s)
      Toyofumi Suzuki
    • Organizer
      The XVth International Symposium of Brain Edema and Cellular Injury (Brain Edema 2011)
    • Place of Presentation
      日本大学会館(東京都)
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血液脳関門におけるレボドパの取り込み輸送に及ぼすパーキンソン病態の影響2011

    • Author(s)
      鈴木豊史,山本拓真,大室綾,渡辺雅紀,古石誉之,深水啓朗,伴野和夫
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 血液脳関門におけるレボドパの取り込み輸送に及ぼすパーキンソン病態の影響2011

    • Author(s)
      鈴木豊史, 山本拓真, 大室綾, 渡辺雅紀, 古石誉之, 深水啓朗, 伴野和夫
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      日本薬学会第131年会要旨集誌上において
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of 1,8-Cineole on the Percutaneous Absorption of Lomerizine Dihydrochloride

    • Author(s)
      Takayuki Furuishi, Toyofumi Suzuki, 他4名
    • Organizer
      The 39th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Qu&eacute;bec City (Canada)
    • Related Report
      2012 Annual Research Report
  • [Presentation] スルファメトキサゾール/トリメトプリム配合剤の投与による血清クレアチニンの上昇とその要因

    • Author(s)
      鈴木豊史,他7名
    • Organizer
      日本薬学会第133年会(横浜)
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Book] Brain Edema XV2013

    • Author(s)
      Toyofumi Suzuki, Yumiko Miyazaki, Aya Ohmuro, Masaki Watanabe, Takayuki Furuishi, Toshiro Fukami, Kazuo Tomono, Springer, Brain Edema XV(Acta Neurochirurgica Supplement 118)
    • Related Report
      2012 Final Research Report
  • [Book] Brain Edema XV (Acta Neurochirurgica Supplement 118)2013

    • Author(s)
      Toyofumi Suzuki, 他6名
    • Total Pages
      352
    • Publisher
      Springer Verlag GmbH
    • Related Report
      2012 Annual Research Report
  • [Book] Nanomedicine and the Cardiovascular System2011

    • Author(s)
      Toshiro Fukami, Toyofumi Suzuki Ayyalusamy Ramamoorthy and Kazuo Tomono
    • Publisher
      Science Publishers
    • Related Report
      2012 Final Research Report
  • [Book] Nanomedicine and the Cardiovascular System2011

    • Author(s)
      Toshiro Fukami
    • Publisher
      Science Publishers
    • Related Report
      2011 Annual Research Report
  • [Remarks] 薬が脳に到達するメカニズムに挑戦

    • URL

      http://www.pha.nihon-u.ac.jp/page.jsp?id=1390

    • Related Report
      2012 Final Research Report
  • [Remarks] 薬が脳に到達するメカニズムの解明に挑戦

    • URL

      http://www.pha.nihon-u.ac.jp/page.jsp?id=1390

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.pha.nihon-u.ac.jp/page.jsp?id=1390

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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