Potential use of supramolecular cyclodextrins for the design of patient- friendly super-generic drug formulations
| Project/Area Number |
22590164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IOHARA Daisuke 崇城大学, 薬学部, 助手 (40454954)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 親水性シクロデキストリン / 包接複合体 / グリメピリド / 次世代型口腔内崩壊錠 / 嚥下性向上 / 放出制御, スーパージェネリック製剤 / シクロデキストリン / 両親媒性製剤素材 / 放出制御 / スーパージェネリック製剤 / クロルプロパミド / 可溶化 / フラーレン / 粒子径の制御 / 抗ヒスタミン薬 / ファモチジン / 安定化 / 苦味軽減 / スーパージェネリック薬 |
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| Research Abstract |
2-Hydroxybutyl-β-CyD (HB-β-CyD) is a new hydroxyalkylated β-CyD derivative that has one more methylene group in the substituent of 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD). Some physicochemical and biological properties of HB-β-CyD, such as surface activity, moisture sorption, hemolytic activity and solubilizing ability for poorly water-soluble drugs were studied in comparison with those of HP-β-CyD. Then, a combined use of various CyDs and stearoxy ether of hydroxypropylmethylcellulose (SangeloseR) was investigated to improve usability of orally disintegrating tablets (ODTs). Glimepiride, a potent third generation hypoglycemic agent for type 2 diabetes was used as a model drug, because it is poorly water-soluble with long linear structure and biological half life is short. Solubility and NMR studies demonstrated that glimepiride formed water-soluble complexes with CyDs, where the magnitude of the stability constant increased in the order of HB-β-CyD > HP-β-CyD > β-CyD > γ-CyD D
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Improvement of Some Physicochemical Properties of Arundic Acid, (R)-(-)-2-Propyloctanonic Acid, by Complexation with Hydrophilic Cyclodextrins2011
Author(s)
Y.Miyamoto, M.Nakahara, K.Motoyama, T.Ishiguro, Y.Oda, T.Yamanoi, I.Okamoto, A.Yagi, H.Nishimura, F.Hirayama, K.Uekama, H.Arima
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Journal Title
International Journal of Pharmaceutics
Volume: 413
Issue: 1-2
Pages: 63-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of carboxymethyl-β-cyclodextrin with acid function : Improvement of chemical stability, oral bioavailability and bitter taste of famotidine.2010
Author(s)
F.M.Mady, A.E.Abou-Taleb, K.A.Khaled, K.Yamasaki, D.Iohara, K.Taguchi, M.Anraku, F.Hirayama, K.Uekama, M.Otagiri
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Journal Title
International Journal of Pharmaceutics
Volume: 397
Pages: 1-8
Related Report
Peer Reviewed
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