Epidermal fatty acid binding protein (EFAP/FABP5) expression is associated with differential transcytosis of M cells in C57BL/6 mice Peyer's patch
Project/Area Number |
22590186
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Akita University |
Principal Investigator |
SUZUKI Ryoji 秋田大学, 大学院・医学系研究科, 准教授 (20396550)
|
Co-Investigator(Kenkyū-buntansha) |
ABE Hiroshi 秋田大学, 大学院・医学系研究科, 教授 (40151104)
|
Co-Investigator(Renkei-kenkyūsha) |
OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 組織学 / M細胞 / E-FABP / パイエル板 / EndoA cytokeratin / Cytokeratin19 / Galectin4 / 抗原取り込み / Caco2 / cytokeratin19 / galectin4 |
Research Abstract |
Epidermal fatty acid binding protein (EFAP/FABP5) expression in M cell in C57BL/6 mice Peyer's patch drastically increased during intestinal flora conversion. Terminal web accumulation ofEFABP in M cell might be driven by EFABP-galectin4 complex synthesis. Both in vivo and in vitro study showed that aboveEFABP expression conversion andEFABP-galectin4 complex were associated with intestinal antigen transcytosis.
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Report
(4 results)
Research Products
(8 results)