| Project/Area Number |
22590212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
SOHMA Yoshiro 慶應義塾大学, 医学部, 准教授 (60268183)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Mariko 慶應義塾大学, 医学部, 助教 (30525811)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Chikara 独立行政法人産業技術総合研究所, 脳神情報研究部門, 研究グループ長 (00357146)
SAKURAI Minoru 東京工業大学, バイオ研究基盤支援総合センター, 教授 (50162342)
YASUI Masato 慶應義塾大学, 医学部, 教授 (90246637)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 / ABCトランスポータ / ATP加水分解 / ATP結合ドメイン / CFTR / 結合エネルギー / ゲーティング / 水和 / Nucleotide Binding Domain |
|---|
| Research Abstract |
Investigating the ATP-dependent gating kinetics of CFTR channel, a member of ABC transporter superfamily in detail revealed a loose coupling between ATP-hydrolysis cycle (chemical energy generated) and the pore gating cycle (mechanical energy consumed) as
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