Study for ATP-driven transport mechanism of ABC transporters based on the "ATP hydrolysis switch" hypothesis.
Project/Area Number |
22590212
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Keio University |
Principal Investigator |
SOHMA Yoshiro 慶應義塾大学, 医学部, 准教授 (60268183)
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Co-Investigator(Kenkyū-buntansha) |
HAYASHI Mariko 慶應義塾大学, 医学部, 助教 (30525811)
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Co-Investigator(Renkei-kenkyūsha) |
SATO Chikara 独立行政法人産業技術総合研究所, 脳神情報研究部門, 研究グループ長 (00357146)
SAKURAI Minoru 東京工業大学, バイオ研究基盤支援総合センター, 教授 (50162342)
YASUI Masato 慶應義塾大学, 医学部, 教授 (90246637)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 / ABCトランスポータ / ATP加水分解 / ATP結合ドメイン / CFTR / 結合エネルギー / ゲーティング / 水和 / Nucleotide Binding Domain |
Research Abstract |
Investigating the ATP-dependent gating kinetics of CFTR channel, a member of ABC transporter superfamily in detail revealed a loose coupling between ATP-hydrolysis cycle (chemical energy generated) and the pore gating cycle (mechanical energy consumed) as
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Curcumin and genistein additively potentiate G551D-CFTR.2011
Author(s)
Yu YC, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, Yasui M, Tanaka K, Hwang TC, Bompadre SB, Sohma Y.
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Journal Title
J. Cystic Fibrosis
Volume: 10
Issue: 4
Pages: 243-252
DOI
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Peer Reviewed
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[Book] Pharmaceutical implications of curcumin in the development of drugs for CF pharmacotherapy: combined effects with genistein In: Curcumin: Biosynthesis, Medicinal Uses and Health Benefits2012
Author(s)
Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SGand Hwang TC
Publisher
Editors Sasaki J & KichidaM, Nova Science Publishers, Hauppauge, New York, USA.
Related Report
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[Book] Curcumin: Biosynthesis, Medicinal Uses and Health Benefits2012
Author(s)
Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SG, Hwang TC.
Total Pages
12
Publisher
Nova Science Publishers, New York, USA
Related Report
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