Ghrelin, a feeding related peptide, and circadian entrainment to the restricted feeding schedule in CS mice
| Project/Area Number |
22590222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Fukui |
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Principal Investigator |
ABE Hiroshi 福井大学, 医学部, 教授 (80201896)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生物時計 / グレリン / サーカディアンリズム / 制限摂食 / 行動 / リズム同調 / 体内時計 / 視交叉上核 / CSマウス / 同調 |
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| Research Abstract |
The circadian clock in CS mice entrains to restricted feeding schedule (RF). Behavioral rhythm and clock gene rhythms in the supurachiasmatic nucleus (SCN, a central oscillator in the circadian clock system) of CS mice show clear entrainment to RF (food entrainment). To investigate the mechanisms of RF entrainment in CS mice, present study was designed to clarify the role of ghrelin, which is a peptide closely related to feeding behavior, in the food entrainment in CS mice. Plasma ghrelin concentration levels in RF mice were increased prior to feeding time, while there were no rhythmic changes in ad lib feeding mice. Periodic ghrelin administration induced no changes in behavioral freerunning rhythms under DD. These results indicate t hat ghrelin is not a major cue for food entrainment of circadian clock in the CS mice . The present results suggest that ghrelin might have a role in the food-entrainable oscillator which regulates food anticipatory activity under RF.
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Report
(4 results)
Research Products
(7 results)
