Changes in emotional and learning behavior evoked by environmentalstress; role of microglia in the brain
| Project/Area Number |
22590225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 感染インストレス / 疲労 / 学習記憶 / 海馬 / インターロイキン1β / インターロイキン-6 / poly I:C / 感染ストレス / ミクログリア / IL^6 / リポポリサッカライド / βアミロイド蛋白 / プラズマローゲン / グリア細胞 / IL-6 / ミノサイクリン / 長期増強 / 情動 / IL-1β / セロトニントランスポーター / Poly I:C |
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| Research Abstract |
(1) Impairment of learning and memory and fatigue in rats induced by peripheral infection stresses were blocked by minocycline, which is known to suppress activation of microglia. (2) Application of Il-1β to primary culture of rat astrocytes induces expression of serotonin transporters. (3) Poly I:C-induced impairment of water maze test in rats was due to IL-6, which expressed in the hippocampus. (4) Everyday injection of LPS (i.p.) in adult mice for 7 days induced accumulation ofβamyloid protein in the hippocampus and prefrontal cortex, which was attenuated by co-application of plasmalogens.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and ss-amyloid accumulation in adult mice2012
Author(s)
Katafuchi, T., Ifuku, M., Mawatari, S., Noda, M., Miake, K., Sugiyama, M. and Fujino, T
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Journal Title
Ann N.Y. Acad. Sci
Volume: 1262
Pages: 85-92
Related Report
Peer Reviewed
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[Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord2010
Author(s)
Yanagisawa, Y., Furue, H., Kawamata, T., Uta, D., Yamamoto, J., Furuse, S., Katafuchi, T., Imonto, K., Iwamoto, Y. and Yoshimura, M
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Journal Title
Mol. Pain
Volume: 6
Pages: 38-50
DOI
Related Report
Peer Reviewed
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[Journal Article] TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur2010
Author(s)
Uta, D., Furue, H., Pickering, A.E., Rashid, M.H., Mizuguchi-Takase, H., Katafuchi, T., Imoto K. and Yoshimura, M
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Journal Title
J. Neurosci
Volume: 31
Pages: 1960-1973
Related Report
Peer Reviewed
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[Presentation] Immunologically induced fatigue and glial cells2010
Author(s)
Katafuchi, T., Ifuku, M., Take, S., Izumi, K., Otsubo, S. and Noda, M
Organizer
The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
Place of Presentation
Kagoshima
Related Report
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