Changes in emotional and learning behavior evoked by environmentalstress; role of microglia in the brain

• Project/Area Number: 22590225
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kyushu University
• Principal Investigator: KATAFUCHI Toshihiko 九州大学, 医学研究院, 准教授 (80177401)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 感染インストレス / 疲労 / 学習記憶 / 海馬 / インターロイキン1β / インターロイキン-6 / poly I:C / 感染ストレス / ミクログリア / IL^6 / リポポリサッカライド / βアミロイド蛋白 / プラズマローゲン / グリア細胞 / IL-6 / ミノサイクリン / 長期増強 / 情動 / IL-1β / セロトニントランスポーター / Poly I:C

Research Abstract

(1) Impairment of learning and memory and fatigue in rats induced by peripheral infection stresses were blocked by minocycline, which is known to suppress activation of microglia. (2) Application of Il-1β to primary culture of rat astrocytes induces expression of serotonin transporters. (3) Poly I:C-induced impairment of water maze test in rats was due to IL-6, which expressed in the hippocampus. (4) Everyday injection of LPS (i.p.) in adult mice for 7 days induced accumulation ofβamyloid protein in the hippocampus and prefrontal cortex, which was attenuated by co-application of plasmalogens.

Research Products

• [Journal Article] Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats (2012)
  • Author(s): Mawatari, S., Katafuchi, T., Miake, K. and Fujino, T
  • Journal Title: Lipids Health Dis Volume: 11 Pages: 161-161
  • Peer Reviewed
• [Journal Article] Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice. (2012)
  • Author(s): Ifuku M, Katafuchi T, Mawatari S, Noda M, Miake K, Sugiyama M and Fujino T.
  • Journal Title: J Neuroinflammation Volume: 9 Issue: 1 Pages: 197-210
  • DOI: 10.1186/1742-2094-9-197
  • Peer Reviewed
• [Journal Article] Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and ss-amyloid accumulation in adult mice (2012)
  • Author(s): Katafuchi, T., Ifuku, M., Mawatari, S., Noda, M., Miake, K., Sugiyama, M. and Fujino, T
  • Journal Title: Ann N.Y. Acad. Sci Volume: 1262 Pages: 85-92
  • Peer Reviewed
• [Journal Article] Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice. (2012)
  • Author(s): Katafuchi, T.
  • Journal Title: Ann N.Y. Acad. Sci. Volume: 1262 Pages: 85-92
  • Peer Reviewed
• [Journal Article] Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats. (2012)
  • Author(s): Mawatari, S.
  • Journal Title: Lipids Health Dis. Volume: 11 Pages: 161-161
  • Peer Reviewed
• [Journal Article] Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice (2012)
  • Author(s): Katafuchi T., et al
  • Journal Title: Ann N.Y.Acad.Sci. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Hypothalamo- sympathetic modulation of splenic natural killer cell activity: an involvement of brain cytokines (2011)
  • Author(s): Katafuchi, T
  • Journal Title: Adv. Neuroimmun. Biol Volume: 1 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Introduction: advances in neuroimmune biology: a comprehensive way to look at biology (2011)
  • Author(s): Berczi, I. and Katafuchi, T
  • Journal Title: Adv. Neuroimmun. Biol Volume: 1 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Introduction : advances in neuroimmune biology : a comprehensive way to look at biology (2011)
  • Author(s): Berczi, I., Katafuchi, T
  • Journal Title: Adv.Neuroimmuns Biol. Volume: 1 Issue: 1 Pages: 1-9
  • DOI: 10.3233/nib-2011-001
  • Peer Reviewed
• [Journal Article] Hypothalamo-Sympathetic modulation of splenic natural killer cell activity : an involvement of brain cytokines (2011)
  • Author(s): Katafuchi, T.
  • Journal Title: Adv.Neuroimmuns Biol. Volume: 1 Issue: 1 Pages: 63-69
  • DOI: 10.3233/nib-2011-006
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord (2010)
  • Author(s): Yanagisawa, Y., Furue, H., Kawamata, T., Uta, D., Yamamoto, J., Furuse, S., Katafuchi, T., Imonto, K., Iwamoto, Y. and Yoshimura, M
  • Journal Title: Mol. Pain Volume: 6 Pages: 38-50
  • DOI: 10.1186/1744-8069-6-38
  • Peer Reviewed
• [Journal Article] TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur (2010)
  • Author(s): Uta, D., Furue, H., Pickering, A.E., Rashid, M.H., Mizuguchi-Takase, H., Katafuchi, T., Imoto K. and Yoshimura, M
  • Journal Title: J. Neurosci Volume: 31 Pages: 1960-1973
  • Peer Reviewed
• [Journal Article] Enhancement of GABAergic tonic currents by midazolam and noradrenaline in rat substantia gelantinosa neurons in vitro (2010)
  • Author(s): Maeda, A., Katafuchi, T., Oba, Y., Shiokawa, H. and Yoshimura, M
  • Journal Title: Anesthesiology Volume: 113 Pages: 429-437
  • Peer Reviewed
• [Journal Article] 疲労と免疫 (2010)
  • Author(s): 片渕俊彦
  • Journal Title: CLINICAL NEUROSCIENCE Volume: 第28巻 第2号 Pages: 159-161
• [Journal Article] 免疫学的疲労モデルにおける疲労の分子神経メカニズム (2010)
  • Author(s): 片渕俊彦
  • Journal Title: 最新・疲労の科学. 別冊 医学のあゆみ Pages: 27-31
• [Journal Article] 免疫学的疲労と脳内グリア細胞 (2010)
  • Author(s): 片渕俊彦, 井福正隆
  • Journal Title: 日本疲労学会誌 Volume: 第5巻 第2号 Pages: 30-34
  • Peer Reviewed
• [Journal Article] Enhancement of GABAergic Tonic Currents by Midazolam and Noradrenaline in Rat Substantia Gelantinosa Neurons In Vitro. (2010)
  • Author(s): Maeda, A., et al.
  • Journal Title: Anesthesiology. Volume: 113 Pages: 429-437
  • Peer Reviewed
• [Presentation] Plasmalogens attenuate lipopolysaccharide-induced β-amyloid accumulation in mice (2012)
  • Author(s): Katafuchi, T., Ifuku, M, Fujino, T., Shiro Mawatari
  • Organizer: The 10^<th> Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: Gyeongju, Korea
  • Year and Date: 2012-02-17
• [Presentation] 免疫学的疲労モデル動物における脳内炎症機序 (2012)
  • Author(s): 片渕俊彦, 井福正隆
  • Organizer: シンポジウム「疲労の脳科学の最前線」第8回日本疲労学会総会・学術集会. 日本疲労学会誌
  • Place of Presentation: 東京
• [Presentation] Plasmalogens attenuate lipopolysaccharide-induced b-amyloid accumulation in miceSymposium session I, Cell signaling and information processing (1) (2012)
  • Author(s): Katafuchi, T., Ifuku, M, Fujino, T. and Shiro Mawatari
  • Organizer: The 10th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: Gyeongju, Republic of Korea
• [Presentation] 免疫学的疲労モデル動物における脳内炎症機序. (2012)
  • Author(s): 片渕俊彦
  • Organizer: 第8回日本疲労学会総会・学術集会.
  • Place of Presentation: 東京
• [Presentation] Neuroinflammation in an animal model of poly I:C-induced fatigue (2011)
  • Author(s): Katafuchi, T., Ifuku, M., Take, S.
  • Organizer: The 8^<th> Congress of the International Society for Neuroimmunommodulation
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2011-10-21
• [Presentation] Role of glial cells in immunologically induced fatigue (2011)
  • Author(s): Katafuchi, T.
  • Organizer: The III International Symposium : Interaction of the nervous and immune systems in health and disease
  • Place of Presentation: St.Petersburg, Russia(招待講演)
  • Year and Date: 2011-06-07
• [Presentation] Neuroinflammation in an animal model of poly I:C-induced fatigue. Section 3: The brain in Neuroimmunomodulation (2011)
  • Author(s): Katafuchi, T., Ifuku, M. and Take, S
  • Organizer: The 8th Congress of the International Society for Neuroimmunommodulation
  • Place of Presentation: Dresden, GERMANY
• [Presentation] Role of glial cells in immunologically induced fatigue. Plenary lecture (2011)
  • Author(s): Katafuchi, T
  • Organizer: The III International Symposium: Interaction of the nervous and immune systems in health and disease
  • Place of Presentation: St. Petersburg, RUSSIA
• [Presentation] Immunologically induced fatigue and glial cells. (2010)
  • Author(s): Katafuchi, T., et al
  • Organizer: The 9^<th> Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles.
  • Place of Presentation: KKR Hotel Keitenkaku(鹿児島市)
  • Year and Date: 2010-11-26
• [Presentation] Immunologically induced fatigue and glial cells (2010)
  • Author(s): Katafuchi, T., Ifuku, M., Take, S., Izumi, K., Otsubo, S. and Noda, M
  • Organizer: The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Kagoshima
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/physiol/
• [Remarks] 九州大学大学院統合生理学分野
  • URL: http://www.med.kyushu-u.ac.jp/physiol/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/physiol/