Redox regulation of endoplasmic reticulum stress and signals by reactive oxygen species

• Project/Area Number: 22590262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Yamagata University
• Principal Investigator: FUJII Junichi 山形大学, 大学院・医学系研究科, 教授 (00222258)
• Co-Investigator(Kenkyū-buntansha): YOSHIHITO Iuchi 山口大学, 農学部, 准教授 (60272069)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 小胞体ストレス / レドックス調節 / 活性酸素シグナル / アポトーシス / シャペロン

Research Abstract

We have analyzed roles of Prx4 by using Prx4-knockout mice and obtained following results. (1) Testes-specific Prx4 transcript was present, which suggests potential role of the variant in spermatogenesis.(2)Analyses of Prx4-deficient B cells indicated a significant role of Prx4 in oxidative folding of IgM.(3) Prx4 was found to suppress the cell growth stimulated by granuloctye-colony stimulating factor. (4) Mice that lack Ero1 and Prx4 became scurvy due to vitamin C deficiency. Thus we are gradually unveiling intra-and extra-cellular functions of Prx4.

Research Products

• [Journal Article] Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice (2012)
  • Author(s): Ester Zito, Henning Gram Hansen, Giles S. H. Yeo, Junichi Fujii, and David Ron.
  • Journal Title: Mol Cell Volume: 48 Issue: 1 Pages: 39-51
  • DOI: 10.1016/j.molcel.2012.08.010
  • Peer Reviewed
• [Journal Article] A malfunction in the triglyceride transfer from the intracellular lipid pool to the apoB in the enterocytes of SOD1・deficient mice. (2012)
  • Author(s): Kurahashi Toshihiro, Konno Tasuku, Otsuki Noriyuki, Kwon Myoungsu, Tsunoda Satoshi, Ito Junitsu, Fujii Junichi
  • Journal Title: FEBS letters Volume: 586 Issue: 24 Pages: 4289-4295
  • DOI: 10.1016/j.febslet.2012.09.047
  • Peer Reviewed
• [Journal Article] Impaired fertilizing ability of Sodl-deficient mouse sperm during in-vitro fertilization. (2012)
  • Author(s): Tsunoda Satoshi, Kawano Natsuko, Miyado Kenji, Kim ura Naoko, Fujii Junichi.
  • Journal Title: Biology of reproduction Volume: 87 Issue: 5 Pages: 1-6
  • DOI: 10.1095/biolreprod.112.102129
  • Peer Reviewed
• [Journal Article] Measurement of Peroxiredoxin-4 in Rat Tissues and Implication of Its Serum Levels as a Potential Marker for Hepatic Disease. (2012)
  • Author(s): Ritsu Ito
  • Journal Title: Mol Med Report Volume: 6 Issue: 2 Pages: 379-384
  • DOI: 10.3892/mmr.2012.935
  • Peer Reviewed
• [Journal Article] In vivo role of aldehyde reductase (2012)
  • Author(s): Motoko Takahashi
  • Journal Title: Bichim Biophys Acta Volume: 1820 Issue: 11 Pages: 1787-1796
  • DOI: 10.1016/j.bbagen.2012.07.003
  • Peer Reviewed
• [Journal Article] Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative stress-inducing agent paraquat (2012)
  • Author(s): Sho Kobayashi
  • Journal Title: Free Radic Biol Med Volume: 53 Issue: 12 Pages: 2197-2203
  • DOI: 10.1016/j.freeradbiomed.2012.09.040
  • Peer Reviewed
• [Journal Article] 細胞内外で多様な機能を発揮するレドックス分子・ぺルオキシレドキシン-4 (2012)
  • Author(s): 藤井順逸
  • Journal Title: 日本応用酵素協会誌 Volume: 47 Pages: 19-27
• [Journal Article] 酸化ストレスと女性生殖機能-活性酸素のもつ細胞内シグナルとしての役割 (2012)
  • Author(s): 藤井順逸
  • Journal Title: Hormone Frontier in Gynecology Volume: 19 Pages: 143-147
• [Journal Article] 細胞増殖に関わるリン酸化・脱リン酸化の制御における活性酸素種のシグナル伝達分子としての役割 (2012)
  • Author(s): 藤井順逸
  • Journal Title: Vitamemebrane Volume: 12 Pages: 1-9
• [Journal Article] Measurement of Peroxiredoxin-4 in Rat Tissues and Implication of Its Serum Levels as a Potential Marker for Hepatic Disease (2012)
  • Author(s): Ritsu Ito, Motoko Takahashi, Hideyuki Ihara, Hiroki Tsukamoto, Junichi Fujii, Yoshitaka Ikeda
  • Journal Title: Mol Med Report Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Identification and characterization of an alternatively transcribed form of peroxiredoxin IV that is specifically expressed in spermatids of the postpubertal mouse testis (2011)
  • Author(s): Sun Hee Yim, Yoo-Jin Kim, Sue Young Oh, Junichi Fujii, Yan Zhang, Vadim N. Gladyshev, and Sue Goo Rhee
  • Journal Title: J Biol Chem Volume: 286 Issue: 45 Pages: 39002-39012
  • DOI: 10.1074/jbc.m111.257220
  • Peer Reviewed
• [Journal Article] Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface (2011)
  • Author(s): Karishma Palande, Onno Roovers, Judith Gits, Carola Verwijmeren, Yoshihito Iuchi, Junichi Fujii, Benjamin G Neel, Robert Karisch, Jan Tavernier, and Ivo P Touw
  • Journal Title: J Cell Sci Volume: 124 Issue: 21 Pages: 3695-3705
  • DOI: 10.1242/jcs.089656
  • Peer Reviewed
• [Journal Article] Different consequences of the reactions with hydrogen peroxide and t-butyl hydro peroxide in the hyperoxidative inactivation of rat peroxiredoxin-4 (2011)
  • Author(s): Yoshitaka Ikeda, Miyako Nakano, Hideyuki Ihara, Ritsu Ito, Naoyuki Taniguchi, Junichi Fujii
  • Journal Title: J Biochem Volume: 149 Issue: 4 Pages: 443-453
  • DOI: 10.1093/jb/mvq156
  • Peer Reviewed
• [Journal Article] Redox regulation of fertilisation and the spermatogenic process (2011)
  • Author(s): Junichi Fujii, Satoshi Tsunoda
  • Journal Title: Asian Journal of Andrology Volume: VOL.13 Issue: 3 Pages: 420-423
  • DOI: 10.1038/aja.2011.10
  • Peer Reviewed
• [Journal Article] Development of a Quantitative Bioassay to Assess Preventive Compounds against Inflammation-based Carcinogenesis (2011)
  • Author(s): Kunishige Onuma, Yuka Suenaga, Ryuta Sakaki, Satoshi Yoshitome, Yu Sato, Satomi Ogawara, Saori Suzuki, Mitsuhiro Kuramitsu, Hidekatsu Yokoyama, Akira Murakami, Junichi Hamada, Garth L Nicolson, Masanobu Kobayashi, Junichi Fujii, Futoshi Okada
  • Journal Title: Nitric Oxide Volume: 25 Issue: 2 Pages: 183-194
  • DOI: 10.1016/j.niox.2011.02.003
  • Peer Reviewed
• [Journal Article] Introduction to serial reviews: physiological relevance of antioxid/redox genes; learning from genetically modified animals (2011)
  • Author(s): Junichi Fujii
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 2 Pages: 69-69
  • DOI: 10.3164/jcbn.10-138SRInt
  • NAID: 130004466648
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Unveiling the roles of the glutathione redox system <i>in vivo</i> by analyzing genetically modified mice (2011)
  • Author(s): Junichi Fujii, Jun-itsu Ito, Xuhong Zhang, Toshihiro Kurahashi
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 2 Pages: 70-78
  • DOI: 10.3164/jcbn.10-138SR
  • NAID: 130004466649
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Different consequences of the reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4 (2011)
  • Author(s): Ikeda, Yoshitaka
  • Journal Title: J Biochem Volume: 149 Pages: 443-453
  • Peer Reviewed
• [Journal Article] Development of a Quantitative Bioassay to Assess Preventive Compounds against Inflammation-based Cazcinogenesis (2011)
  • Author(s): Onuma, Kunishige
  • Journal Title: Nitric Oxide Volume: 印刷中
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Fujii, Junichi
  • Journal Title: J CIin Biochem Nutr Volume: 印刷中
  • Peer Reviewed
• [Journal Article] B to plasma cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses (2010)
  • Author(s): Milena Bertolotti, Sun Hee Yim, Jose M. Garcia-Manteiga, Silvia Masciarelli, Yoo-Jin Kim, Min-Hee Kang, Yoshihito Iuchi, Junichi Fujii, Roberta Vene, Anna Rubartelli, Sue Goo Rhee, Roberto Sitia
  • Journal Title: Antioxid Redox Signal Volume: 13 Issue: 8 Pages: 1133-1144
  • DOI: 10.1089/ars.2009.3079
  • Peer Reviewed
• [Journal Article] Implication of oxidative stress as a cause of autoimmune hemolytic anemia in the NZB mice (2010)
  • Author(s): Yoshihito Iuchi, Noriko Kibe, Satoshi Tsunoda, Saori Suzuki, Takeshi Mikami, Futoshi Okada, Koji Uchida, and Junichi Fujii
  • Journal Title: Free. Radic. Biol. Med. Volume: 48 Issue: 7 Pages: 935-944
  • DOI: 10.1016/j.freeradbiomed.2010.01.012
  • Peer Reviewed
• [Journal Article] Intrinsic oxidativestress causes either two-cell arrest or cell death depending on developmental stage of the embryo from SOD1-deficient mice (2010)
  • Author(s): Naoko Kimura, Satoshi Tsunoda, Yoshihito Iuchi, Hiroyuki Abe, Kiyoshi Totsukawa, and Junichi Fujii
  • Journal Title: Mol. Hum. Reprod Volume: 16 Issue: 7 Pages: 441-451
  • DOI: 10.1093/molehr/gaq007
  • Peer Reviewed
• [Journal Article] Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies (2010)
  • Author(s): Otaki, N., Chikazawa, M., Nagae, R., Shimozu, Y., Shibata, T., Ito, S., Takasaki, Y., Fujii, J., and Uchida, K.
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 44 Pages: 33834-33842
  • DOI: 10.1074/jbc.m110.165175
  • Peer Reviewed
• [Journal Article] Intrinsic oxidative stress causes either two-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice (2010)
  • Author(s): Kimura, Naoko.
  • Journal Title: Mol Hum Reprod Volume: 16 Pages: 441-451
  • Peer Reviewed
• [Journal Article] Implication of oxidative stress as a cause of autoimmune hemolytic anemia in the NZB mice. (2010)
  • Author(s): Iuchi, Yoshihito
  • Journal Title: Free Radic Biol Med Volume: 48 Pages: 935-944
  • Peer Reviewed
• [Journal Article] Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells. (2010)
  • Author(s): Ikeda, Yoshitaka
  • Journal Title: Protein Expr Purif Volume: 72 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Spontaneous skin damage and delayed wound healing in SOD1-deficient mice. (2010)
  • Author(s): Iuchi, Yoshihito
  • Journal Title: Mol Cell Biochem Volume: 341 Pages: 181-194
  • Peer Reviewed
• [Journal Article] B to plasma cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. (2010)
  • Author(s): Bertolotti, Milena
  • Journal Title: Antioxid Redox Signal Volume: 13 Pages: 1133-1144
  • Peer Reviewed
• [Journal Article] Identification of a lipid peroxidation product as the source ofoxidation-specific epitopes recognized by anti-DNA autoantibodies (2010)
  • Author(s): Otaki, Natsuki
  • Journal Title: J Biol Chem Volume: 285 Pages: 33834-33842
  • Peer Reviewed
• [Presentation] Roles of Peroxiredoxin 4 in ROS Signaling, Oxidative Protein Folding in ER, and Spermatogenesis (2012)
  • Author(s): Junichi Fujii (invited speaker)
  • Organizer: UK-Japan Research Symposium; Molecular Mechanisms of Stress Response in Disease
  • Place of Presentation: Tsukuba University, Ibaraki
• [Presentation] Roles of Peroxiredoxin 4 in ROS Signaling, Oxidative Protein Folding in ER, and Spermatogenesis (2012)
  • Author(s): Junichi Fujii
  • Organizer: UK-Japan Research Symposium; Molecular Mechanisms of Stress Response in Disease
  • Place of Presentation: 筑波大学（茨城県）
  • Invited
• [Presentation] Impairment of Mammalian Gametes and Embryo by Reactive Oxygen Species, 6-7 Apr, 2012, Tsukuba, Japan (2012)
  • Author(s): Satoshi Tsunoda
  • Organizer: UK-Japan Research Symposium; Molecular Mechanisms of Stress Response in Disease
  • Place of Presentation: 筑波大学（茨城県）
• [Presentation] Validation of involvement of reactive oxygen species in autoimmune hemolytic anemia by genetic modification of SOD1in NZB mice. (2012)
  • Author(s): Tasuku Konno
  • Organizer: The 33rd Naito Conference on Oxygen Biology: Hypoxia, Oxidative Stress and Diseases
  • Place of Presentation: シャトレーゼ ガトーキングダム サッポロ（北海道）
• [Presentation] SOD1 deficiency causes postprandial dyslipidemia due to impaired lipid metabolism in the intestine. (2012)
  • Author(s): Toshihiro Kurahashi
  • Organizer: 16th Biennial Meeting of the Society for Free Radical Research International
  • Place of Presentation: ロンドン大学キングスカレッジ（ロンドン・英国）
• [Presentation] Impairment of sperm in in vitro fertility by SOD1 deficiency (2012)
  • Author(s): Satoshi Tsunoda
  • Organizer: 16th Biennial Meeting of the Society for Free Radical Research International
  • Place of Presentation: ロンドン大学キングスカレッジ（ロンドン・英国）
• [Presentation] Oxidative stress as a cause for autoimmune hemolytic anemia; supporting evidences from genetically modified mice (2012)
  • Author(s): Junichi Fujii
  • Organizer: 16th Biennial Meeting of the Society for Free Radical Research International
  • Place of Presentation: ロンドン大学キングスカレッジ（ロンドン・英国）
• [Presentation] SOD1欠損による精子内因性酸化ストレス亢進が引き起こす体外受精率低下機構 (2012)
  • Author(s): 角田智志
  • Organizer: 第65回日本酸化ストレス学会
  • Place of Presentation: 徳島県郷土文化会館（徳島県）
• [Presentation] SOD1欠損マウス小腸における脂質代謝の解析 (2012)
  • Author(s): 倉橋敏裕
  • Organizer: 第65回日本酸化ストレス学会
  • Place of Presentation: 徳島県郷土文化会館（徳島県）
• [Presentation] 酸化ストレス亢進による小腸の脂質代謝異常 (2012)
  • Author(s): 倉橋敏裕
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] SOD1欠損細胞を用いた抗酸化物質の新規評価系の開発 (2012)
  • Author(s): 井内 良仁
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] Aldehyde reductase欠損によるアスコルビン酸合成障害のPentobarbital代謝に与える影響 (2012)
  • Author(s): 伊藤 純一
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] Aldehyde reductase (AKR1A)欠損によるアスコルビン酸合成障害の血液系に与える影響 (2012)
  • Author(s): 金野 祐
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] SOD1欠損マウス精子の体外受精率低下機構の解析 (2012)
  • Author(s): 角田 智志
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 肝臓の解毒反応におけるアルデヒド還元酵素の役割の遺伝子改変マウスを用いた解明 (2012)
  • Author(s): 伊藤純一
  • Organizer: 第16回日本肝臓学会大会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 活性酸素のもつ二面性:生体傷害と細胞増殖・老化の制御 (2011)
  • Author(s): 藤井順逸
  • Organizer: 第12回Vitamemebrane研究会
  • Place of Presentation: 経団連会館(東京)(招待講演)
  • Year and Date: 2011-07-23
• [Presentation] Peroxiredoxin 4 is a multifunctional redox protein working in endoplasmic reticulum and cytoplasm (2011)
  • Author(s): Junichi Fujii (poster), Yoshihito Iuchi, Xuhong Zhang, Satoshi Tsunoda, and Yoshitaka Ikeda
  • Organizer: International Symposium on Free Radical Research: Contribution to Medicine (FRCM2011)
  • Place of Presentation: Iburikawa, Kyoto
• [Presentation] 赤血球を酸化ストレスによるレドックスバランスの破綻から護る抗酸化機構 (2011)
  • Author(s): 藤井順逸(シンポジスト)
  • Organizer: 第64回日本酸化ストレス学会
  • Place of Presentation: ルスツ、北海道
• [Presentation] Aldehyde reductase deficiency prolongs pentobarbital induced hypsosis in mice (2011)
  • Author(s): Junitsu Ito, Motoko Takahashi, Noriyuki Otsuki, Tasuku Konno, Hayato Nishida, Satoshi Tsunoda, Toshihiro Kurahashi, Xuhong Zhang, Satoshi Miyata, Junichi Fujii
  • Organizer: 4th Symposium on Nutrition, Oxygen Biology and Medicine
  • Place of Presentation: Hotel de Seine (Paris, France)
• [Presentation] Roles of peroxiredoxin 4 in protein sulfhyryl oxidation (2011)
  • Author(s): Toshihiro Kurahashi, Chihiro Awada, Tasuku Konno, Noriyuki Otsuki, Satoshi Tsunoda, Xuhong Zhang, Junitsu Ito, Yoshihito Iuchi, Toshifumi Takao, Junichi Fujii
  • Organizer: 5th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM)
  • Place of Presentation: Kagoshima Citizens' Culture Hall (Kagoshima)
• [Presentation] Influences of the SOD1 deficiency on the gamete quality in in-vitro fertilization (2011)
  • Author(s): Satoshi Tsunoda, Naoko Kimura, Hiroyuki Abe, Akihiro Watanabe, Junichi Fujii
  • Organizer: 5th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM)
  • Place of Presentation: Kagoshima Citizens' Culture Hall (Kagoshima)
• [Presentation] Implication of oxidative stress as a cause of autoimmune hemolytic anemia (2011)
  • Author(s): Yoshihito Iuchi, Futoshi Okada, Junichi Fujii
  • Organizer: Montreal, Modern Medical Forum 2011
  • Place of Presentation: EPS Global Medical Development Inc.(Montreal, Canada)
• [Presentation] 内因性酸ストレス蓄積によマウス2細胞期発生停止へのCDKインヒビターの関与の可能性 (2011)
  • Author(s): 角田智志、木村直子、藤井順逸
  • Organizer: 第52回日本哺乳動物卵子学会
  • Place of Presentation: 国際医療福祉大学(大田原)
• [Presentation] SOD1欠損が雄性生殖能に与える影響 (2011)
  • Author(s): 角田智志、藤井順逸
  • Organizer: 第64回日本酸化ストレス学会
  • Place of Presentation: ルスツリゾートホテル・コンベンション(ルスツ,北海道)
• [Presentation] 酸化還元酵素アルデヒドレダクターゼノックアウトマウスで発症するアスコルビン酸欠乏症とその影響 (2011)
  • Author(s): 高橋素子、宮田哲、藤井順逸、井内陽子、上山茂充、曽我朋義、藤縄玲子、荒木素子、谷口直之、黒木由夫
  • Organizer: 第64回日本酸化ストレス学会
  • Place of Presentation: ルスツリゾートホテル・コンベンション(ルスツ,北海道)
• [Presentation] 赤血球を酸化ストレスによるレドックスバランスの破綻から護る抗酸化機構 (2011)
  • Author(s): 藤井順逸
  • Organizer: 第64回日本酸化ストレス学会
  • Place of Presentation: ルスツリゾートホテル・コンベンション(ルスツ,北海道)(招待講演)
• [Presentation] 過酸化PeoxiredoxinIIの検出による赤血球レドックスバランスと機能の解明 (2011)
  • Author(s): 伊藤純一、倉橋敏裕、金野祐、大槻倫之、角田智志、張旭紅、藤井順逸
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] NZマウスの自己免疫疾患発症に対する赤血球酸化名kストレスの関与 (2011)
  • Author(s): 金野祐、大槻倫之、鈴木紗織、岐部紀子、角田智志、井内良仁、藤井順逸
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] SOD1欠損マウス胎仔線維芽細胞を用いた酸化ストレス誘導性細胞周期停止機構の解析 (2011)
  • Author(s): 角田智志、岐部紀子、藤井順逸
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] 炎症発癌を標的とした予防化合物の定量的検出系の開発 (2011)
  • Author(s): 末永裕佳、坂木隆太、小沼邦重、村上明、田中宏樹、浜田淳一、小林正伸、藤井順逸、岡田太
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] 肝細胞癌におけるmiR-224の機能解析 (2011)
  • Author(s): 張旭紅、邵力、渡辺久剛、縢亮、齋藤貴史、石井里佳、横澤潤二、木村理、藤井順逸、深尾彰
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Roles of peroxiredoxin 4 in protein sulfhyryl oxidation (2011)
  • Author(s): Toshihiro Kurahashi, Chihiro Awada. Tasuku Konno, Noriyuki Otsuki, Satoshi Tsunoda, Xuhong Zhang, Junitsu Ito, Yoshihito Iuchi, Toshifumi Takao, Junichi Fujii
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Peroxiredoxin 4 is a multifunctional redox protein working in endoplasmic reticulum and cytoplasm (2011)
  • Author(s): Fujii, Junichi
  • Organizer: International Symposium on Free Radical Research
  • Place of Presentation: Kyoto
• [Presentation] Prx4の抗酸化活性による活性酸素シグナルの制御 (2010)
  • Author(s): 藤井順逸(ワークショップ)
  • Organizer: 第33回日本分子生物学会第83回日本生化学合同年会
  • Place of Presentation: 神戸国際会議場、兵庫
• [Presentation] SOD1欠損マウス胎児線維芽Prx4の抗酸化活性による活性酸素シグナルの制御 (2010)
  • Author(s): 藤井順逸
  • Organizer: 第33回日本分子生物学会第83回日本生化学合同年会
  • Place of Presentation: 神戸
• [Presentation] ベルオキシレドキシンによる抗酸化と活性酸素シグナルの制御 (2010)
  • Author(s): 藤井順逸
  • Organizer: 第27回臨床フリーラジカル会議
  • Place of Presentation: 京都
• [Book] Antithetical Roles of Reactive Oxygen Species in Mammalian Reproduction r In Handbook of System Biology of Free Radicals and Anti-oxidants (2013)
  • Author(s): Junichi Fujii, Satoshi Tsunoda, and Naoko Kimura
  • Publisher: Springer-Verlag(I. Larher ed)(in press)
• [Book] Handbook of System Biology of Free Radicals and Anti-oxidants (2013)
  • Author(s): Junichi Fujii
  • Total Pages: 17
  • Publisher: Antithetical Roles of Reactive Oxygen Species in Mammalian Reproduction
• [Book] Handbook of System Biology of Free Radicals and Anti-oxidants (2012)
  • Author(s): Junichi Fujii, Satoshi Tsunoda, Naoko Kimura
  • Publisher: Antithetical Roles of Reactive Oxygen Species in Mammalian Reproduction(印刷中)
• [Book] In "Male and Female Infertility: Genetic Causes, Hormonal Treatments and Health Effects." (Bjorn Glantz and Klas Edquist eds), Nova Science Publishers, Inc (2010)
  • Author(s): Junichi Fuji, Yoshihito Iuchi
  • Publisher: Requirement of Multiple Antioxidative/Redox Systems to Support Male Fertility
• [Book] Male and Female Infertility:Genetic Causes, Hormonal Treatments and Health Effects (2010)
  • Author(s): Fujii, Junichi
  • Total Pages: 22
  • Publisher: Nova Science Publishers
• [Book] Male and Female Infertility:Genetic Causes, Hormonal Treatments and Health Effects (2010)
  • Author(s): Kimura, Naoko
  • Total Pages: 21
  • Publisher: Nova Science Publishers
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/BiochemII/b2.html
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/BiochemII/b2.html
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/BiochemII/b2.html