Role of Wnt signal modulators in malignancy of cancer
| Project/Area Number |
22590282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAZUI Toru 筑波大学, 医学医療系, 教授 (80235613)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Wntシグナル / プロテオミクス / 分子標的薬 / 腎明細胞癌 / 肝細胞がん / 質量分析 / 遺伝子発現解析 / シグナル伝達 / 腎がん / 肝がん / Wnt / siRNA / 浸潤 / 腎明細胞がん |
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| Research Abstract |
In this study, we analyzed the mechanisms of Wnt signaling modulator in carcinogenesis and malignant transformation. We have found overexpression of novel Wnt modulator. Membrane Protein X (MPX) by ‘omics’ analysis of liver cancer. Functional analysis of MPX by over-expression of cDNA and siRNA knockdown for MPX revealed this new Wnt signaling modulator promote cancer invasion in liver cancer.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.2012
Author(s)
Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M
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Journal Title
Blood
Volume: 120
Pages: 914-914
Related Report
Peer Reviewed
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[Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.2012
Author(s)
Takase H, Matsumoto H, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M
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Journal Title
Blood
Volume: 120
Pages: 914-23
DOI
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of glypican-3 in human hepatocellular carcinoma2010
Author(s)
Suzuki M, Sugimoto K, Tanaka J, Tameda M, Inagaki Y, Kusagawa S, Nojiri K, Beppu T, Yoneda K, Yamamoto N, Ito M, Yoneda M, Uchida K, Takase K, Shiraki K
Volume
Vol.30
Pages
5055-61
Related Report
Peer Reviewed
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[Journal Article] Functional cell surface expression of Toll-like receptor 9 promotes cell proliferation and survival in human hepatocellular carcinomas2010
Author(s)
Tanaka J, Sugimoto K, Shiraki K, Tameda M, Kusagawa S, Nojiri K, Beppu T, Yoneda K, Yamamoto N, Uchida K, Kojima T, Takei Y
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Journal Title
Int J Oncol
Volume: 37
Pages: 805-14
Related Report
Peer Reviewed
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[Journal Article] Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis2010
Author(s)
Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Murata H, Tsutsumi A, Hayashi T, Uchida K, Usui J, Yamagata K, Sumida T.
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Journal Title
Clin Exp Immunol.
Volume: Vol.159
Pages: 1-10
Related Report
Peer Reviewed
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[Presentation] dentification of serum biomarkers for transaminase-negative chronic hepatitis and nonalcoholic fatty liver disease by proteomics2012
Author(s)
Uchida K., Suzuki H, Meno K, Korenaga T, Nagashima R, Sugimoto K, Toyota H, Kumada S, Okanoue T, Shiraki K
Organizer
The 21th Asian Pacific Association for the Study of the Liver (APASL 2011) (Plenary lecture)
Place of Presentation
Bangkok, Thailand
Year and Date
2012-02-18
Related Report
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[Presentation] New Strategy for Identification and Assay Development of Circulating Peptide Biomarkers for Chronic Liver Disease and Hepatocellular Carcinoma.2010
Author(s)
Uchida K, Suzuki, H., Meno, K., Ishii, T., Sugimoto, K., Nagashima, N., Shiraki, K.
Organizer
国際ヒトプロテオーム機構HUPO 9th World Congres.
Place of Presentation
Sydney, Australia
Year and Date
2010-09-09
Related Report
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[Presentation] Quantitative Peptidomic Analysis Reveals Novel Circulating Biomarkers for Chronic Inflammation in Transaminase-Negative Chronic Hepatitis and Nonalcoholic Fatty Liver Disease.2010
Author(s)
Suzuki, H., Meno, K., Korenaga, T., Ishii, T., Sugimoto, K., Nagashima, R., Shiraki, K., Uchida, K
Organizer
国際ヒトプロテオーム機構HUPO 9th World Congres
Place of Presentation
Sydney, Australia
Year and Date
2010-09-09
Related Report
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