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Studies on signaling pathways mediated by Nucling, a novel apoptosis-associating protein, in the development of inflammatory disorders and tumors

Research Project

Project/Area Number 22590286
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokushima

Principal Investigator

SAKAI Takashi  徳島大学, 疾患酵素学研究センター, 准教授 (80284321)

Co-Investigator(Kenkyū-buntansha) FUKUI Kiyoshi  徳島大学, 疾患酵素学研究センター, 教授 (00175564)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsヌクリング / NF-κB / アポトーシス / 炎症性疾患 / 発ガン / Nucling / 肝炎・肝癌
Research Abstract

We revealed that Nucling is important for the strict regulationof NF-・B signal in resting state. Aberrant activation of NF-・B in Nucling-deficient tissues or cells showed defect of apoptosis pathways resulted in the resistance against cytotoxic stress. It is possibly one of the factors for the high prevalence ratios of hepatitis and hepatic cancer. These results will lead to the elucidation of the regulatory mechanism of the pathogenesis of the diseases or to the development of novel therapeutic strategies.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (46 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (32 results) Remarks (2 results)

  • [Journal Article] Nucling, a novel protein associated with NF-・B, regulates endotoxin-induced apoptosis in vivo2013

    • Author(s)
      Sun Mi Kim, Sakai, T., Huy Van Dang, Nam Hoang Tran, Ono, K., Ishimura, K. and Fukui, K
    • Journal Title

      J. Biochem

      Volume: Vol. 153、No. 1 Issue: 1 Pages: 93-101

    • DOI

      10.1093/jb/mvs119

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of kupffer cells in carbon tetrachloride intoxication in mice2012

    • Author(s)
      Kiso, K., Ueno, S., Fukuda, M., Ichi, I., Kobayashi, K., Sakai, T., Fukui, K., Kojo, S
    • Journal Title

      Biol. Pharm. Bull

      Volume: Vol. 35、No. 6 Pages: 980-983

    • NAID

      130001872185

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22687543

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice2012

    • Author(s)
      Kaori Kiso
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 6 Pages: 980-983

    • DOI

      10.1248/bpb.35.980

    • NAID

      130001872185

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate2012

    • Author(s)
      Salah Mohamed El Sayed, et al
    • Journal Title

      Cancer Gene Therapy

      Volume: 19 Issue: 1 Pages: 40-926

    • DOI

      10.1038/cgt.2011.59

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects2012

    • Author(s)
      Salah Mohamed El Sayed, et al
    • Journal Title

      Journal of Bioenergetics and Biomembranes

      Volume: 44 Issue: 1 Pages: 61-79

    • DOI

      10.1007/s10863-012-9409-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice2010

    • Author(s)
      Sakai, T., Liu, L., Teng, X. C., Ishimaru, N., Mukai-Sakai, R., Tran, N. H., Kim, S. M., Sano, N., Hayashi, Y., Kaji, R. and Fukui, K
    • Journal Title

      Int. J. Cancer

      Volume: Vol. 126 Issue: 5 Pages: 1079-1094

    • DOI

      10.1002/ijc.24789

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation2010

    • Author(s)
      Tran N H, Sakai, T., Kim, S. M. and Fukui, K
    • Journal Title

      J Biochem

      Volume: Vol. 148、No.5 Issue: 5 Pages: 573-580

    • DOI

      10.1093/jb/mvq089

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Effect of Risperidone on D-Amino Acid Oxidase Activity as a Hypothesis for a Novel Mechanism of Action in the Treatment of Schizophrenia2010

    • Author(s)
      Rabab M., Abou El-Magd
    • Journal Title

      Journal of Psychopharmacology

      Volume: 24 Pages: 1055-1067

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation2010

    • Author(s)
      Nam Hoang Tran
    • Journal Title

      Journal of Biochemistry

      Volume: 148 Pages: 573-580

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase2010

    • Author(s)
      Seong Pit Chung
    • Journal Title

      Journal of Biochemistry

      Volume: 148 Pages: 743-753

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioprocess development of the production of the mutant P-219-L human D-amino acid oxidase for high soluble fraction expression in recombinant Escherichia coli2010

    • Author(s)
      Rabab M., Abou El-Magd
    • Journal Title

      Biochemical Engineering Journal

      Volume: 52 Pages: 236-247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of Kupffer cells in carbon tetrachloride intoxieation in mice

    • Author(s)
      Kiso K, et al
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規NF-・B制御分子ヌクリングは非アルコール性脂肪肝及び糖尿病発症抑制に重要で或る2012

    • Author(s)
      坂井隆志
    • Organizer
      第16回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      東京都港区
    • Year and Date
      2012-11-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ホモシステイン代謝系における新規NF-・B制御因子ヌクリングの関与2012

    • Author(s)
      佐古有季哉
    • Organizer
      日本ビタミン学会第64回大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2012-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規NF-・B制御分子ヌクリングの炎症性病態への関与についての検討2012

    • Author(s)
      金善美
    • Organizer
      第53回日本生化学会 中国・四国支部例会
    • Place of Presentation
      岡山市
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] ホモシステイン代謝系における新規NF-κB制御因子ヌクリングの関与2012

    • Author(s)
      佐古 有季哉
    • Organizer
      日本ビタミン学会第64回大会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規NF-κB制御分子ヌクリングは非アルコール性脂肪肝及び糖尿病発症抑制に重要である2012

    • Author(s)
      坂井 隆志
    • Organizer
      第16回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 四塩化炭素中毒におけるKupffer細胞による肝炎拡大機構2012

    • Author(s)
      木曽 かおり
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規NF-κB制御分子ヌクリングはLPS刺激により誘導される細胞死を制御している2012

    • Author(s)
      金 善美
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] D-アミノ酸代謝システムの活性制御による新規精神神経疾患治療戦略2011

    • Author(s)
      福井清
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規アポトーシス/NF-κB制御分子ヌクリングの機能解析2011

    • Author(s)
      坂井隆志
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Combination of oxidative stress and energy depletion induced significant glioma cell death2011

    • Author(s)
      Salah M.EL-SAYED
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトD-アミノ酸酸化酵素のグリア細胞内における機能解析2011

    • Author(s)
      宍戸裕二
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規アポトーシス/ NF-κB制御分子ヌクリングの機能解析2011

    • Author(s)
      坂井隆志
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] アストログリア細胞内のD-アミノ酸酸化酵素によりD-セリンから産生されるヒドロキシピルビン酸の細胞死誘導活性2011

    • Author(s)
      鄭丞弼
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-アミノ酸酸化酵素の遺伝子導入により、グリオーマ細胞では、3-ブロモピルビン酸の解糖系への阻害作用が増強される2011

    • Author(s)
      Salah M.El Sayed
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Modulation of D-amino acid oxidase activity as a novel strategy for the treatment of psychiatric disorders2011

    • Author(s)
      Fukui Kisyohi
    • Organizer
      Function and dysfunction of D←amino acids in the central nervous system
    • Place of Presentation
      東京医科歯科大学(東京都)(招待講演)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-アミノ酸酸化酵素の活性制御による新規精神神経疾患治療戦略2011

    • Author(s)
      福井清
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] グリア細胞におけるD-アミノ酸酸化酵素の機能解析2011

    • Author(s)
      宍戸裕二
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規NF-kB制御分子ヌクリングの免疫系における役割の検討2011

    • Author(s)
      金善美
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島大学(広島県)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-amino acid oxidase gene therapy sensitizes glioma cells to the anti-glycolytic effect of 3-bromopyruvate2011

    • Author(s)
      Salah M.El Sayed
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島大学(広島県)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規NF-・B制御分子ヌクリングの免疫系における役割の検討2011

    • Author(s)
      金善美
    • Organizer
      第52回日本生化学会 中国・四国支部例会
    • Place of Presentation
      広島市
    • Year and Date
      2011-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Intracellular metabosim of Nucling, a novel apoptosis regulator2010

    • Author(s)
      Nam Hoang Tran
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intracellular metabolism of Nucling, a novel apoptosis regulator2010

    • Author(s)
      Sakai T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Physiological function of a novel NF-・B-regulating molecule, Nucling, in immune system2010

    • Author(s)
      金善美
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Physiological Function of a novel NF-κB-regulating molecule, NUCLING, in Immune system2010

    • Author(s)
      Sun Mi Kim
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nucling a novel apoptosis-associating protein, regulates NF-kB pathway2010

    • Author(s)
      Takashi Sakai
    • Organizer
      The 12th IUBMB, 21st FAOBMB & ComBio2010 Conferences
    • Place of Presentation
      Melbourne convention and Exhibition Centre(オーストラリア・メルボルン市)
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] D-amino acid oxidase : pathophysiological basis and moleculaz target for schizophrenia2010

    • Author(s)
      Kiyoshi Fukui
    • Organizer
      The 12th IUBMB, 21st FAOBMB & ComBio2010 Conferences
    • Place of Presentation
      Melbourne convention and Exhibition Centre(オーストラリア・メルボルン市)
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nucling, a novel apoptosis-associating protein, regulates NF-・B pathway、OzBio20102010

    • Author(s)
      Sakai, T.
    • Organizer
      the 12th IUBMB, 21st FAOBMB & ComBio2010 Conferences
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Physiological function of a novel NF-・B-regulating molecule, Nucling, in immune system 、OzBio20102010

    • Author(s)
      Kim S. M
    • Organizer
      the 12th IUBMB, 21stFAOBMB & ComBio2010 Conferences
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Physiological Function of a Novel NF-κB-Regulating Molecule, Nucling, in Immune System2010

    • Author(s)
      Sun Mi Kim
    • Organizer
      The 12th IUBMB, 21st FAOBMB & ComBio2010 Conferences
    • Place of Presentation
      Melbourne convention and Exhibition Centre(オーストラリア・メルボルン市)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規アポトーシス誘導因子Nuclingのホモシステイン代謝系における関与2010

    • Author(s)
      佐古有季哉
    • Organizer
      日本ビタミン学会第62回大会
    • Place of Presentation
      アイーナ(盛岡市)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規アホトーシス制御分子NuclingはNF-κB、プロテアソーム及びカスパーゼに制御される2010

    • Author(s)
      Tran Hoang Nam
    • Organizer
      第51回日本生化学会中国四国支部例会
    • Place of Presentation
      山口大学大学会館(山口市)
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規 NF-kB 制御分子ヌクリングの炎症性病態への関与についての検討

    • Author(s)
      金 善美
    • Organizer
      第53回日本生化学会中国・四国支部例会
    • Place of Presentation
      岡山大学(岡山県)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ier.tokushima-u.ac.jp/article/0017774.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ier.tokushima-u.ac.jp/article/0017774.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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