Studies on signaling pathways mediated by Nucling, a novel apoptosis-associating protein, in the development of inflammatory disorders and tumors
| Project/Area Number |
22590286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKAI Takashi 徳島大学, 疾患酵素学研究センター, 准教授 (80284321)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUI Kiyoshi 徳島大学, 疾患酵素学研究センター, 教授 (00175564)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ヌクリング / NF-κB / アポトーシス / 炎症性疾患 / 発ガン / Nucling / 肝炎・肝癌 |
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| Research Abstract |
We revealed that Nucling is important for the strict regulationof NF-・B signal in resting state. Aberrant activation of NF-・B in Nucling-deficient tissues or cells showed defect of apoptosis pathways resulted in the resistance against cytotoxic stress. It is possibly one of the factors for the high prevalence ratios of hepatitis and hepatic cancer. These results will lead to the elucidation of the regulatory mechanism of the pathogenesis of the diseases or to the development of novel therapeutic strategies.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Nucling, a novel protein associated with NF-・B, regulates endotoxin-induced apoptosis in vivo2013
Author(s)
Sun Mi Kim, Sakai, T., Huy Van Dang, Nam Hoang Tran, Ono, K., Ishimura, K. and Fukui, K
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Journal Title
J. Biochem
Volume: Vol. 153、No. 1
Issue: 1
Pages: 93-101
DOI
Related Report
Peer Reviewed
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[Journal Article] The role of kupffer cells in carbon tetrachloride intoxication in mice2012
Author(s)
Kiso, K., Ueno, S., Fukuda, M., Ichi, I., Kobayashi, K., Sakai, T., Fukui, K., Kojo, S
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Journal Title
Biol. Pharm. Bull
Volume: Vol. 35、No. 6
Pages: 980-983
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice2010
Author(s)
Sakai, T., Liu, L., Teng, X. C., Ishimaru, N., Mukai-Sakai, R., Tran, N. H., Kim, S. M., Sano, N., Hayashi, Y., Kaji, R. and Fukui, K
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Journal Title
Int. J. Cancer
Volume: Vol. 126
Issue: 5
Pages: 1079-1094
DOI
Related Report
Peer Reviewed
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