Neural differentiation dysfunction in cells with autosomal imbalance
Project/Area Number |
22590301
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human genetics
|
Research Institution | Tottori University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | ゲノム医科学 / 染色体工学 |
Research Abstract |
Although particular chromosomal syndromes are phenotypically and clinically distinct, the majority of individuals with autosomal imbalance, such as Down syndrome, manifest mental retardation. To study the developmental stages of complex neuronal diseases, several independent disomic and trisomic human ES (T21-hES) and iPS (DS-iPS) cell lines were generated and subsequently differentiated into neuronal progenitor cells. Whereas T21-ES and DS-iPS cells generated neurons similarly to disomic control cells, expression pattern of neural differentiation markers in these cells was different from that of controls.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study2012
Author(s)
Imaoka N, Hiratsuka M, Osaki M, Kamitani H, Kambe A, Fukuoka J, Kurimoto M, Nagai S, Okada F, Watanabe T, Ohama E, Kato S, Oshimura M
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Journal Title
Oncol. Rep
Volume: 28
Issue: 3
Pages: 923-930
DOI
Related Report
Peer Reviewed
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[Journal Article] A new chromosome 14-based human artificial chromosome (HAC) vectorsystem for efficient transgene expression in human primary cells2011
Author(s)
Kakeda M, Nagata K, Osawa K, Matsuno H, Hiratsuka M, Sano A, Okazaki A, Shitara S, Nishikawa S, Masuya A, Hata T, Wako S, Osaki M, Kazuki Y, Oshimura M, Tomizuka K
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Journal Title
Biochem Biophys Res Commun
Volume: 415
Issue: 3
Pages: 439-444
DOI
Related Report
Peer Reviewed
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[Journal Article] Refined human artificial chromosome vectors for gene therapy and animal transgenesis2010
Author(s)
Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N and Oshimura M
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Journal Title
Gene therapy
Volume: Volume 18, number 4
Issue: 4
Pages: 384-93
DOI
Related Report
Peer Reviewed
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