| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Although particular chromosomal syndromes are phenotypically and clinically distinct, the majority of individuals with autosomal imbalance, such as Down syndrome, manifest mental retardation. To study the developmental stages of complex neuronal diseases, several independent disomic and trisomic human ES (T21-hES) and iPS (DS-iPS) cell lines were generated and subsequently differentiated into neuronal progenitor cells. Whereas T21-ES and DS-iPS cells generated neurons similarly to disomic control cells, expression pattern of neural differentiation markers in these cells was different from that of controls.
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