Alteration of apical-basal polarity regulating proteins Par/Lgl/Scrib in lung adenocarcinomas and its relationship with invasion and metastasis
| Project/Area Number |
22590309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKASHI Takumi 東京医科歯科大学, 医学部附属病院, 准教授 (60242202)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Naoyuki 東京医科歯科大学, 医学部附属病院, 助教 (80451912)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺癌 / 極性 / 浸潤突起 / 浸潤 / 極性異常 / 基底膜 / 細胞極性 / ect2 / cortactin / actinin1 |
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| Research Abstract |
Epithelial cells have an apical surface facing a lumen and a basal surface facing extracellular matrix. Abnormality of apical-basal polarity in neoplastic change was examined in the aspect of localization of invadopodia proteins in lung adenocarcinomas. Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells, but rarely in normal bronchiolar epithelial cells, alveolar cells, or precursor neoplastic lesions. Matrix-contact-side localization of invadopodia-related proteins could be histological markers indicative for invasion, metastasis, and poor prognosis. Rho guanine exchange factor/Ect2, one of Par6-binding proteins, was a possible regulator of polarity abnormality in lung adenocarcinomas.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers : significance of interleukin-6 synthesized by stromal cells in response to cancer cells.2010
Author(s)
Kapamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A
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Journal Title
American Journal of Pathology
Volume: 176
Pages: 968-80
Related Report
Peer Reviewed
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