| Project/Area Number |
22590309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKASHI Takumi 東京医科歯科大学, 医学部附属病院, 准教授 (60242202)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Naoyuki 東京医科歯科大学, 医学部附属病院, 助教 (80451912)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺癌 / 極性 / 浸潤突起 / 浸潤 / 極性異常 / 基底膜 / 細胞極性 / ect2 / cortactin / actinin1 |
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| Research Abstract |
Epithelial cells have an apical surface facing a lumen and a basal surface facing extracellular matrix. Abnormality of apical-basal polarity in neoplastic change was examined in the aspect of localization of invadopodia proteins in lung adenocarcinomas. Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells, but rarely in normal bronchiolar epithelial cells, alveolar cells, or precursor neoplastic lesions. Matrix-contact-side localization of invadopodia-related proteins could be histological markers indicative for invasion, metastasis, and poor prognosis. Rho guanine exchange factor/Ect2, one of Par6-binding proteins, was a possible regulator of polarity abnormality in lung adenocarcinomas.
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