The confirmation of HTLV-1 associated Hepatitis

• Project/Area Number: 22590324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kurume University
• Principal Investigator: NIINO Daisuke 久留米大学, 医学部, 准教授 (20426563)
• Co-Investigator(Kenkyū-buntansha): OHSHIMA Koichi 久留米大学, 医学部, 教授 (50203766) ; SUGITA Yasuo 久留米大学, 医学部, 教授 (80216316)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ウイルス / 病理学 / ATLL / HTLV-1 / 肝炎

Research Abstract

We reported four ATLL patients who presented with fulminant hepatitis and analyzed those cases immunohistochemically. Next, we used HBZ gene in situ hybridization (HBZ-ISH) for detection of the HBZ gene in ATLL cell line and ATLL cases. This method is convenient and can be useful for the histological diagnosis of ATLL and HTLV-1-related diseases.

Research Products

• [Journal Article] Classical Hodgkin lymphoma, lymphocyte depleted type: Clinicopathological analysis and prognostic comparison with other types of classical Hodgkin lymphoma. (2013)
  • Author(s): Karube K, et al
  • Journal Title: Pathol Res Pract. Volume: 209 Issue: 4 Pages: 201-207
  • DOI: 10.1016/j.prp.2012.11.003
  • Peer Reviewed
• [Journal Article] Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis. (2013)
  • Author(s): Yoshida N, et al
  • Journal Title: Br J Haematol. Volume: 161 Issue: 2 Pages: 214-223
  • DOI: 10.1111/bjh.12255
  • Peer Reviewed
• [Journal Article] Clinicopathological study of Japanese patients with genetic iron overload syndromes. (2012)
  • Author(s): A. Hattori
  • Journal Title: Pathol. Int. Volume: 62 Issue: 3 Pages: 612-618
  • DOI: 10.1111/pin.12043
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. (2012)
  • Author(s): Suefuji N, Niino D, Sugita Y, Ohshima K 12 番 目) .
  • Journal Title: Pathol Int. Volume: 62(10) Issue: 10 Pages: 690-698
  • DOI: 10.1111/j.1440-1827.2012.02858.x
  • Peer Reviewed
• [Journal Article] Malignant lymphoma of the spleen in Japan: a clinicopathological analysis of 115 cases. (2012)
  • Author(s): Shimizu-Kohno K, et al
  • Journal Title: Pathol Int. Volume: 62 Issue: 9 Pages: 577-582
  • DOI: 10.1111/j.1440-1827.2012.02844.x
  • Peer Reviewed
• [Journal Article] A spindle cell variant of diffuse large B-cell lymphoma is characterized by T-cell/myofibrohistio-rich stromal alterations: analysis of 10 cases and a review of the literature. (2012)
  • Author(s): Kimura Y, et al
  • Journal Title: Eur J Haematol. Volume: 89 Issue: 4 Pages: 302-310
  • DOI: 10.1111/j.1600-0609.2012.01826.x
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-negative classical Hodgkin's lymphoma in a patient with T-cell prolymphocytic leukemia treated with fludarabine. (2012)
  • Author(s): Tsuji T, et al
  • Journal Title: J Clin Exp Hematop. 2012;52(1):71-5. Volume: 52 Pages: 71-75
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-positive lymphoproliferative disorder associated with old organized chronic subdural hematoma. (2012)
  • Author(s): Sugita Y, et al
  • Journal Title: Pathol Int. Volume: 62 Issue: 6 Pages: 412-417
  • DOI: 10.1111/j.1440-1827.2012.02824.x
  • Peer Reviewed
• [Journal Article] Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders. (2012)
  • Author(s): Miyoshi H, et al
  • Journal Title: Am J Clin Pathol. Volume: 137 Issue: 6 Pages: 879-889
  • DOI: 10.1309/ajcpbpnv86vzengv
  • Peer Reviewed
• [Journal Article] Comparison of CD20 expression in B-cell lymphoma between newly diagnosed, untreated cases and those after rituximab treatment. (2012)
  • Author(s): Miyoshi H, et al
  • Journal Title: Cancer Sci. Volume: 103 Issue: 8 Pages: 1567-1573
  • DOI: 10.1111/j.1349-7006.2012.02307.x
  • Peer Reviewed
• [Journal Article] Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdissection: up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5. (2012)
  • Author(s): Toshida S
  • Journal Title: Scand J Rheumatol. Volume: 41 Issue: 3 Pages: 170-179
  • DOI: 10.3109/03009742.2011.623137
  • Peer Reviewed
• [Journal Article] High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma. (2012)
  • Author(s): Yoshida M, et al
  • Journal Title: Pathol Int. 2012 Aug;62(8):518-24. doi: Volume: 62 Issue: 8 Pages: 518-524
  • DOI: 10.1111/j.1440-1827.2012.02835.x
  • Peer Reviewed
• [Journal Article] Primary gastric follicular lymphoma manifesting as a submucosal tumor-like lesion. (2012)
  • Author(s): Norimura D, et al
  • Journal Title: Dig Endosc. Volume: 24 Issue: 5 Pages: 389-389
  • DOI: 10.1111/j.1443-1661.2012.01306.x
  • Peer Reviewed
• [Journal Article] Education and Imaging. Gastrointestinal: gastric mucosa-associated lymphoid tissue (MALT) lymphoma observed by magnifying endoscopy with narrow band imaging. (2012)
  • Author(s): Norimura D, et al
  • Journal Title: J Gastroenterol Hepatol. Volume: 27 Issue: 5 Pages: 987-987
  • DOI: 10.1111/j.1440-1746.2012.07105.x
  • Peer Reviewed
• [Journal Article] Duodenal involvement of mantle cell lymphoma observed by magnified endoscopy with narrow-band imaging. (2012)
  • Author(s): Norimura D, et al
  • Journal Title: Gastrointest Endosc. Volume: 76 Issue: 1 Pages: 188-189
  • DOI: 10.1016/j.gie.2012.02.047
  • Peer Reviewed
• [Journal Article] Gastric involvement by mantle cell lymphoma observed by magnified endoscopy with narrow-band imaging. (2012)
  • Author(s): Norimura D, et al
  • Journal Title: Gastrointest Endosc. Volume: 75 Issue: 2 Pages: 421-422
  • DOI: 10.1016/j.gie.2011.10.018
  • Peer Reviewed
• [Journal Article] FOXP3(+) regulatory and TIA-1(+) cytotoxic T lymphocytes in HIV-associated Hodgkin lymphoma. (2012)
  • Author(s): Kiyasu J, Aoki R, Tanaka PY, Pracchia LF, Calore EE, Perez NM, Kimura Y, Niino D, Sugita Y, Takayanagi R, Abe Y, Matsuoka M, Ohshima K.
  • Journal Title: Pathol Int. Volume: 62 Issue: 2 Pages: 77-83
  • DOI: 10.1111/j.1440-1827.2011.02754.x
  • NAID: 10031185171
  • Peer Reviewed
• [Journal Article] Detection of HTLV-1 by means of HBZ gene in situ hybridization in formalin-fixed and paraffin-embedded tissues (2011)
  • Author(s): Shimizu-Kohno K
  • Journal Title: Cancer Sci Volume: 102 Issue: 7 Pages: 1432-1436
  • DOI: 10.1111/j.1349-7006.2011.01946.x
  • Peer Reviewed
• [Journal Article] Aberrant antigenic expression in extranodal NK/T-cell lymphoma : a multi-parameter study from Thailand (2011)
  • Author(s): Pongpruttipan T, et al
  • Journal Title: Diagn Pathol Volume: 25 Pages: 79-79
  • Peer Reviewed
• [Journal Article] Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm (2011)
  • Author(s): Hashikawa K, et al
  • Journal Title: J Am Acad Dermatol Volume: 66 Pages: 278-291
  • Peer Reviewed
• [Journal Article] Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index (2011)
  • Author(s): Kimura Y, et al
  • Journal Title: Cancer Sci Volume: 102 Issue: 9 Pages: 1734-1741
  • DOI: 10.1111/j.1349-7006.2011.01988.x
  • Peer Reviewed
• [Journal Article] AIDS患者における播種性非結核性抗酸菌症(M.genavense)の1例 (2011)
  • Author(s): 新野大介
  • Journal Title: 診断病理 Volume: 20(1) Pages: 18-20
  • Peer Reviewed
• [Journal Article] Composite Tlymphoblastic leukemia/lymphoma and diffuse large B-cell lymphoma: case report. (2010)
  • Author(s): Niino D, Sugita Y, OhshimaK
  • Journal Title: Path Int. Volume: 61(6) Issue: 8 Pages: 438-442
  • DOI: 10.1111/j.1440-1827.2011.02687.x
  • NAID: 10031185096
  • Peer Reviewed
• [Journal Article] Regression of rectal MALT lymphoma after antibiotic treatments. (2010)
  • Author(s): Niino D, Sugita Y), Ohshima K
  • Journal Title: Path Int. Volume: 60(6) Issue: 6 Pages: 438-442
  • DOI: 10.1111/j.1440-1827.2010.02538.x
  • Peer Reviewed
• [Journal Article] Ratio of M2 macrophage expression is closely associated with AITL (2010)
  • Author(s): Niino D, Sugita Y), Ohshima K
  • Journal Title: Path Int. Volume: 60(4) Issue: 4 Pages: 278-283
  • DOI: 10.1111/j.1440-1827.2010.02514.x
  • Peer Reviewed
• [Journal Article] Ratio of M2 macrophage expression is closely associated with AITL (2010)
  • Author(s): Daisuke Niino
  • Journal Title: Pathology International Volume: 60(4) Pages: 278-283
  • Peer Reviewed
• [Journal Article] Regression of rectal MALT lymphoma after antibiotic treatments. (2010)
  • Author(s): Daisuke Niino
  • Journal Title: Pathology International Volume: 60(6) Pages: 438-442
  • Peer Reviewed
• [Presentation] M2 Macrophage Infiltration Is Closely Associated with Poor Prognosis for Adult T-Cell Leukemia/Lymphoma (ATLL). (2011)
  • Author(s): Niino D.
  • Organizer: Annual Meeting of the American Society of Hematology (ASH)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-12
• [Presentation] M2 Macrophage Infiltration Is Closely Associated with Poor Prognosis for Adult T-Cell Leukemia/Lymphoma (ATLL) (2011)
  • Author(s): Niino D, et al
  • Organizer: Annual Meeting of the American Society of Hematology (ASH)
  • Place of Presentation: San Diego, California
  • Year and Date: 2011-12-12
• [Presentation] CompositeTbothT-andB-cellcomponents(CTBL)の臨床病理学的検討 (2011)
  • Author(s): 新野大介CompositelymphomawithK
  • Organizer: 日本血液学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] Composite lymphoma with both T- and B-cell components (CTBL)の臨床病理学的検討 (2011)
  • Author(s): Niino D, et al
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] Composite lymphoma withK . Composite Tboth T- and B-cell components(CTBL)の臨床病理学的検討 (2011)
  • Author(s): Niino D, Sugita Y), Ohshima新 野 大 介
  • Organizer: 日本血液学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-22
• [Presentation] リンパ節穿刺生検で扁平上皮癌との鑑別が困難であった悪性リンパ腫(DLBCL)の1例 (2011)
  • Author(s): 新野大介, ほか
  • Organizer: 第52回日本臨床細胞学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-22
• [Presentation] ワークショップ10アジアにおけるリンパ増殖性疾患-新たな世界標準を目指して-成人T細胞白血病リンパ腫 (2011)
  • Author(s): 新野大介
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] Regression of rectal MALTlymphoma after antibiotic treatments. (2010)
  • Author(s): 新野大介
  • Organizer: 日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Regression of rectal MALT lymphoma after antibiotic treatments. (2010)
  • Author(s): 新野大介
  • Organizer: 日本血液学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-25
• [Presentation] 慢性甲状腺炎を背景に発症した甲状腺原発Peripheral T-cell lymphoma7症例の臨床病理学的検討
  • Author(s): 新野 大介
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京 京王プラザホテル
• [Presentation] Primary T-cell lymphoma of the thyroid gland associated with Autoimmune thyroiditis; 7 cases
  • Author(s): 新野 大介
  • Organizer: 第74回日本血液学会総会
  • Place of Presentation: 京都 国立国際会館
• [Presentation] Adult T-Cell Leukemia/Lymphoma (ATLL)
  • Author(s): Daisuke Niino
  • Organizer: Asia-Pacific Society for Molecular Immunohistology (APSMI) 7th annual meeting
  • Place of Presentation: Sanur – Bali, Indonesia
  • Invited
• [Book] Mucosa-Associated Lymphoid Tissue (2012)
  • Author(s): Niino D, Ohshima K. Chapter
  • Publisher: (MALT) Lymphoma. In Tech, Hodgkin's Lymphoma
• [Book] Chapter title : Regression of Rectal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma after Antibiotic Treatments (2012)
  • Author(s): Niino D, Ohshima K
  • Publisher: INTECH(in press)