• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A role of dbpA, DNA binding protein in Hodgkin lymphoma

Research Project

Project/Area Number 22590338
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionJuntendo University

Principal Investigator

MOMOSE Shuji  順天堂大学, 医学部, 非常勤講師 (70360344)

Co-Investigator(Kenkyū-buntansha) TAMARU Jun-ichi  埼玉医科大学, 医学部, 教授 (30188429)
梶野 一徳  順天堂大学, 医学部, 助教 (80260066)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsCD30 / dbpA / リンパ腫 / 病理学 / dbpA / Hodgkinリンパ腫 / 悪性リンパ腫
Research Abstract

dbpA, DNA-binding protein A is belived to be involved in DNA recombination in E.Coli. We found dbpA is highly expressed in CD30 positive lymphocytes, which is restricted to activated lymphocyte in normal tissue. Also dbpA is highlyexpressed in CD30+lymphoma, classical Hodgkin lymphoma and anaplastic lymphoma. As it is well known that constitutive activation of NF・B signaling is a characteristic feature of Hodgkin lymphoma, dbpA seemed to act in a downstream molecule of NF・B signaling pathway.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (5 results) Book (6 results)

  • [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL2012

    • Author(s)
      Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N
    • Journal Title

      Clin Cancer Res

      Volume: 18(8) Pages: 2164-72

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL.2012

    • Author(s)
      Kanemitsu N,
    • Journal Title

      Clin Cancer Res.

      Volume: 18(8) Issue: 8 Pages: 2164-2172

    • DOI

      10.1158/1078-0432.ccr-11-2395

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hodgkinリンパ腫における放射線誘発二次発がんの原因遺伝子の解明2012

    • Author(s)
      百瀬修二
    • Journal Title

      血液内科

      Volume: 64(4) Pages: 487-491

    • NAID

      40019312386

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell lymphoma, nasal type (ENKL) : Differences in biological and clinical behaviors of LMP1-positive and -negative ENKL2012

    • Author(s)
      Naoko Kanemitsu, et al
    • Journal Title

      Clin Cancer Res

      Volume: 18 Issue: 8 Pages: 2336-2343

    • DOI

      10.1158/1078-0432.ccr-11-2825

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microscopic polyangitis complicating double carcinoma of the stomach and duodenum: improvement after the resection of these carcinomas2011

    • Author(s)
      be H, Momose S, Takeuchi T
    • Journal Title

      Rheumatol Int

      Volume: 31(1) Pages: 105-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era2010

    • Author(s)
      Hanzawa K, Momose S, Higashi M, Tokuhira M, Watanabe R, Kajino K, Hino O, Itoyama S, Kizaki M, Tamaru J
    • Journal Title

      Leuk Lymphoma

      Volume: 51(11) Pages: 2054-62

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010

    • Author(s)
      Tan K, Kajino K, Momose S, Masaoka A, Sasahara K, Shiomi K, Izumi H, Abe M, Ohtsuji N, Wang T, Hino O, Fujii H
    • Journal Title

      Hum Pathol

      Volume: 41(9) Pages: 1330-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Y-box binding protein-1 expression in diffuse large B-cell lymphoma : an impact on prognosis in the rituximab era.2010

    • Author(s)
      Hanzawa K, Momose S, Higashi M, et al.
    • Journal Title

      Leukemia & Lymphoma

      Volume: 51 Pages: 2054-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter.2010

    • Author(s)
      Tan K, Kajino K, Momose S, et al
    • Journal Title

      Human Pathology

      Volume: 41 Pages: 1330-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胸水・腹水の病理 胸腹水の生化学的マーカー-最近の知見-2010

    • Author(s)
      百瀬修二、樋野興夫
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 1125-8

    • Related Report
      2010 Annual Research Report
  • [Presentation] Oral lichen planusとの鑑別に苦慮したcarcinoma in situを伴うlichenoid dysplasiaの1例2010

    • Author(s)
      川野竜太郎, 下山哲夫, 百瀬修二, 東守洋, 田丸淳一, 糸山進次
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「悪性リンパ腫」日常診断において知っておきたい新たな疾患概念ALK陽性大細胞型B細胞性リンパ腫について2010

    • Author(s)
      百瀬修二
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] びまん性大細胞型B細胞性リンパ腫(DLBCL)におけるYB-1の発現と臨床病理学的意義2010

    • Author(s)
      半澤京子, 得平道英, 渡部玲子, 森茂久, 木崎昌弘, 百瀬修二, 東守洋, 田丸淳一, 梶野一徳, 樋野興夫, 糸山進次
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節リウマチに対する抗TNFα製剤(アダリマブ)投与中に発症した免疫不全関連リンパ増殖性疾患の1例2010

    • Author(s)
      正岡亜希子, 百瀬修二, 田丸淳一, 樋野興夫
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性中皮腫におけるMesothelinプロモーター低メチル化状態とその発現状態2010

    • Author(s)
      譚珂, 梶野一徳, 百瀬修二, 阿部雅明, 泉浩, 樋野興夫, 藤井博昭
    • Organizer
      第99回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Book] 血液内科 第64 巻第4 号2012

    • Author(s)
      百瀬修二
    • Publisher
      科学評論社
    • Related Report
      2012 Final Research Report
  • [Book] 多発性骨髄腫治療マニュアル 第I章 治療の前に B.骨髄腫細胞の形態学的特徴と細胞表面マーカー2012

    • Author(s)
      百瀬修二 田丸淳一
    • Total Pages
      7
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Book] II.悪性リンパ腫 1.改訂第4 版2010

    • Author(s)
      百瀬修二 田丸淳一
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 樋野興夫胸水・腹水の病理 胸腹水の生化学的マーカー -最近の知見-病理と臨牀2010

    • Author(s)
      百瀬修二
    • Related Report
      2012 Final Research Report
  • [Book] 造血器腫瘍治療 2版 これは困ったぞ、どうしよう!2010

    • Author(s)
      百瀬修二
    • Total Pages
      361
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 病理と臨床28(11)2010

    • Author(s)
      百瀬修二、樋野興夫
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi