| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Our global expression analysis of miRNA in synovial sarcoma, a representative human sarcoma, demonstrated overexpression of several miRNAs including let-7e and miR-99b, which are clustered in the same chromosomal locus. Knock down of these miRNAs resulted in reduced cell proliferation, suggesting for the first time that overexpressed such miRNAs may induce sarcomagenesis through down-regulation of their molecular targets such as HMGA2 and SMARCA5 that are known as potential tumor suppressors.
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