Proteomic analyses of Ascaris mitochondrial respiratory chain
| Project/Area Number |
22590383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Tsutomu 順天堂大学, 医学部, 准教授 (70245778)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミトコンドリア / プロテオーム / 回虫 / ウエステルマン肺吸虫 / マンソン裂頭条虫 / 低酸素適応 / 好気的呼吸鎖 / 嫌気的呼吸鎖 / フマル酸還元酵素 / 寄生蠕虫 / C.elegans / シトクロムb_5 / 肺吸虫 / 嫌気的ミトコンドリア / NADH-フマル酸還元酵素 / 好気から嫌気の呼吸転換 / ミトコンドリアの生合成 / テグメント / パランキマ |
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| Research Abstract |
Objectives:This research project was undertaken to elucidate underlying mechanisms for the establishment and maintenance of infection by analyzing expression and regulation of helminth proteins, especially mitochondrial proteins,responding to changing oxygen tension. Achievements:The current research showed: 1)Ascaris suum adult-specific cytochrome b5played the crucial roles in the parasitic adaptation.2)Paragonimus westermani possesses aerobic and anaerobic mitochondria in different tissues, adapting to fluctuating oxygen tension in microaerobic habitats.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article]2010
Author(s)
Shinzaburo Takamiya, Koich Fukuda, Takeshi Nakamura, Takashi Aoki, and Hiromu Sugiyama
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Journal Title
International Journal for Parasitology
Volume: Vol.40
Pages: 1651-1658
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
Shinzaburo Takamiya, Koich Fukuda, Takeshi Nakamura, Takashi Aoki, and Hiromu Sugiyama
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Journal Title
XII International Congress of Parasitology ICOPA
Pages: 129-133
Related Report
Peer Reviewed
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