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Different toxic activities of adenylate cyclase toxins of Bordetella pertussisand Bordetella bronchiseptica

Research Project

Project/Area Number 22590390
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka University

Principal Investigator

KAMITANI Shigeki  大阪大学, 微生物病研究所, 助教 (60379089)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords病原性 / 百日咳 / 細菌毒素 / 宿主特異性 / 百日咳菌
Research Abstract

We found that different toxic activities of adenylate cyclase toxins (ACTs) produced by Bordetella species including B. pertussis, B. parapertussis, and B. bronchisepticacome from the different activities of translocation of ACTs to the target cells. Furthermore, we showed that the different toxic activities among Bordetellaspecies could be a cause of the different pathology of diseases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Defining the substrate specificity of Pasteurella multocida toxin-induced deamidation of α-subunits of heterotrimeric G proteins2013

    • Author(s)
      Orth, J. H., Fester, I., Siegert, P., Weise, M., Lanner, U., Kamitani, S., Tachibana, T., Wilson, B. A., Schlosser, A., Horiguchi, Y., and Aktories,K
    • Journal Title

      FASEB J

      Volume: 27 Issue: 2 Pages: 832-842

    • DOI

      10.1096/fj.12-213900

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway2012

    • Author(s)
      Matsuzawa, T., Kimb B-H., Kamitani, S., Miyake, M., and MacMicking, J. D
    • Journal Title

      J Immunol

      Volume: 189 Issue: 2 Pages: 813-818

    • DOI

      10.4049/jimmunol.1102041

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences Between Group X and Group V Secretory Phospholipase A2 in Lipolytic Modification of Lipoproteins2012

    • Author(s)
      Kamitani, S., Yamada, K., Yamamoto, S., Ishimoto, Y., Ono, T., Saiga, A., and Hanasaki, K.
    • Journal Title

      Cell Mol Biol Lett

      Volume: 17 Issue: 3 Pages: 459-479

    • DOI

      10.2478/s11658-012-0019-2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibody recognizing the deamidated alpha subunit of the heterotrimeric GTPase Gq2011

    • Author(s)
      Kamitani, S., Ao, S., Toshima, H., Tachibana, T., Hashimoto, M., Kitadokoro, K., Fukui-Miyazaki, A., Abe, H., and Horiguchi, Y.
    • Journal Title

      FEBS J

      Volume: 278 Issue: 15 Pages: 2702-2712

    • DOI

      10.1111/j.1742-4658.2011.08197.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal Structure of Clostridiumperfringensenterotoxin displays features of β-pore-forming toxins2011

    • Author(s)
      Kitadokoro, K., Nishimura, K., Kamitani, S., Fukui-Miyazaki, A., Toshima, H., Abe, H., Kamata, Y., Sugita-Konishi, Y., Yamamoto, S., Karatani, H., and Horiguchi, Y
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 22 Pages: 19549-19555

    • DOI

      10.1074/jbc.m111.228478

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bordetella dermonecrotic toxin binds to target cells via the N-terminal 30 amino acids.2011

    • Author(s)
      Fukui-Miyazaki, A., Ohnishi, S., Kamitani, S., Abe, H., and Horiguchi, Y
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 154-159

    • NAID

      10031121454

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bordetella Dermonecrotic Toxin Binds to Target Cells Via the N-Terminal 30 Amino Acids2011

    • Author(s)
      Fukui-Miyazaki, A., S.Ohnishi, S.Kamitani, H.Abe, Y.Horiguchi
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Pages: 154-9

    • NAID

      10031121454

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bordetella dermonecrotic toxin binds to target cells via the N-terminal 30 amino acids.2011

    • Author(s)
      Fukui-Miyazaki A., Kamitani S, et al.
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Pages: 154-159

    • NAID

      10031121454

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Bordetella dermonecrotic toxin with the extracellular matrix2010

    • Author(s)
      Fukui-Miyazaki, A., Kamitani, S., Miyake,M., and Horiguchi, Y
    • Journal Title

      BMC microbiology

      Volume: 10 Issue: 1 Pages: 247-247

    • DOI

      10.1186/1471-2180-10-247

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the membrane-targeting C1 domain in Pasteurella multocidatoxin2010

    • Author(s)
      Kamitani, S., Kitadokoro, K, Miyazawa,M., Toshima, H., Fukui, A., Abe, H., Miyake,M., and Horiguchi, Y.
    • Journal Title

      J Biol Chem

      Volume: 285 Issue: 33 Pages: 25467-25475

    • DOI

      10.1074/jbc.m110.102285

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin.2010

    • Author(s)
      Kamitani, S., et al.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285(33) Pages: 25467-25475

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Bordetella dermonecrotic toxin with the extracellular matrix.2010

    • Author(s)
      Fukui-Miyazaki, A., Kamitani S, et al.
    • Journal Title

      BMC Microbiology

      Volume: 10 Pages: 247-255

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] IVET-IP 法:ラット感染中の気管支敗血症菌の遺伝子発現プロファイル解析2013

    • Author(s)
      安倍裕順,神谷重樹,福井理,岡田圭祐,堀口安彦
    • Organizer
      第86回細菌学会総会
    • Place of Presentation
      千葉・幕張メッセ国際会議場
    • Year and Date
      2013-03-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 気管支敗血症菌の新たな病原因子2013

    • Author(s)
      西川明芳,安倍裕順,岡田圭祐,神谷重樹,福井理,堀口安彦
    • Organizer
      第86回細菌学会総会
    • Place of Presentation
      千葉・幕張メッセ国際会議場
    • Year and Date
      2013-03-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 気管支敗血症菌の新たな病原因子2013

    • Author(s)
      西川明芳、安倍裕順、岡田圭祐、神谷重樹、福井理、堀口安彦
    • Organizer
      第86回細菌学会総会
    • Place of Presentation
      千葉 幕張メッセ 国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] IVET-IP法:ラット感染中の気管支敗血症菌の遺伝子発現プロファイル解析2013

    • Author(s)
      安倍裕順、神谷重樹、福井理、岡田圭祐、堀口安彦
    • Organizer
      第86回細菌学会総会
    • Place of Presentation
      千葉 幕張メッセ 国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] IVET-IP system to screen Bordetella genes expressed in animal infection models2012

    • Author(s)
      安倍裕順, 神谷重樹, 福井理, 戸嶋ひろ野, 堀口安彦
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎・長崎ブリックホール/長崎新聞文化ホール
    • Year and Date
      2012-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 病原細菌の宿主特異性決定因子の解明2012

    • Author(s)
      安倍裕順,神谷重樹,堀口安彦,東秀明
    • Organizer
      第1回 人獣共通感染症研究拠点シンポジウム
    • Place of Presentation
      札幌・北海道大学
    • Year and Date
      2012-06-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Different activities of adenylate cyclase toxins of Bordetella pertussisand B. bronchiseptica2012

    • Author(s)
      戸嶋ひろ野, 福井理, 安倍裕順, 神谷重樹 , 堀 口安 彦
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎・長崎ブリックホール/長崎新聞文化ホー
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Different activities of adenylate cyclase toxins of Bordetella pertussis and Bordetella bronchiseptica2012

    • Author(s)
      戸嶋ひろ野、福井理、安倍裕順、神谷重樹、堀口安彦
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール長崎新聞文化ホール
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 病原細菌の宿主特異性決定因子の解明2012

    • Author(s)
      安倍裕順、神谷重樹、堀口安彦、東秀明
    • Organizer
      第1回 人獣共通感染症研究拠点シンポジウム
    • Place of Presentation
      北海道札幌 北海道大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 感染成立過程で発現する病原細菌遺伝子の網羅的解析法の開発2011

    • Author(s)
      安倍裕順, 神谷重樹, 福井理, 戸嶋ひろ野, 堀口安彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] ウェルシュ菌の産生する食中毒病原因子 CPE の構造および機能解析2011

    • Author(s)
      西村昂亮, 神谷重樹, 福井理, 戸嶋ひろ野, 安倍裕順, 鎌田洋一, 小西良子,山本茂貴, 柄谷肇, 堀口安彦, 北所健悟
    • Organizer
      第26回日本結晶学会年会
    • Year and Date
      2011-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] THE PORE-FORMING MECHANISM OF CLOSTIRIDIUM PERFRINGENS ENTEROTOXIN TARGETING CLAUDINS, COMPONENTS OF THE TIGHT JUNCTION2011

    • Author(s)
      堀口安彦, 北所健吾, 西村昂亮, 神谷重樹, 安倍裕順
    • Organizer
      第84回日本細菌学会総会
    • Place of Presentation
      札幌・札幌コンベンションセンター
    • Year and Date
      2011-09-10
    • Related Report
      2012 Final Research Report
  • [Presentation] ウェルシュ菌エンテロトキシンの分子構造のβ型孔形成毒素の特徴2011

    • Author(s)
      北所健吾, 西村昂亮, 神谷重樹, 福井理, 戸嶋ひろ野, 安倍裕順, 鎌田洋一, 小西良子, 山本茂貴, 柄谷肇, 堀口安彦
    • Organizer
      第58回毒素シンポジウム
    • Place of Presentation
      東京・順天堂大学本郷キャンパス
    • Year and Date
      2011-07-07
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://bactox1.biken.osaka-u.ac.jp/2011Web/Horiguchis_Lab_top.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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