The structure and biosynthesis of glycopeptidolipid antigens from non-tureculous acid-fast bacteria, and their host responses
| Project/Area Number |
22590399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MAEDA Shinji 結核予防会結核研究所, 抗酸菌レファレンス部結核菌情報科, 科長 (50250212)
YANO Ikuya 日本 BCG 製造株式会社中央研究所, 顧問 (60047008)
NAKA Takashi 株式会社 MBR, 主任研究員 (40426599)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 構造・生理 / 非結核性抗酸菌症 / 宿主応答 / 脂質分子 / 感染症 / 非結核性抗酸菌 / 脂質 / 国際研究者交流、韓国 / 細菌 / 糖鎖 |
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| Research Abstract |
Mycobacterium avium-intracellulare complex (MAC), which causes pulmonary and extrapulmonary diseases, is the most common isolate of nontuberculous mycobacteria. MAC species are classifiable into 28 serotypes according to the epitopic oligosaccharide struc
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance.2013
Author(s)
N. Fujiwara, S.A. Porcelli, T. Naka, I. Yano, S. Maeda, H. Kuwata, S. Akira, S. Uematsu, T. Takii, H. Ogura, K. Kobayashi
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Journal Title
Biochim. Biophys. Acta.
Volume: 1831
Pages: 1177-1184
Related Report
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[Journal Article] Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density2012
Author(s)
H. Yamada, A. Bhatt, R. Danev, N. Fujiwara, S. Maeda, S. Mitarai, K. Chikamatsu, A. Aono, K. Nitta, W.R. Jacobs Jr., K. Nagayama
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Journal Title
Tuberculosis (Edinb)
Volume: 92
Pages: 351-357
Related Report
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[Journal Article] Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.2012
Author(s)
Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki K.
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Journal Title
Antimicrob Agents Chemother.
Volume: 56(8)
Issue: 8
Pages: 4140-5
DOI
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Peer Reviewed
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[Journal Article] The structure and host recognition of serotype 13 glycopeptidolipid fromMycobacterium intracellulare2011
Author(s)
T. Naka, N. Nakata, S. Maeda, R. Yamamoto, M. Doe, S. Mizuno, M. Niki, K. Kobayashi, H. Ogura, M. Makino, and N. Fujiwara
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Journal Title
J. Bacterial.
Volume: 193
Pages: 5766-5774
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[Presentation] Deletion of glycopeptidolipids in Mycobacterium smegmatis J15cs strain and its host responses.2012
Author(s)
N. Fujiwara, T. Naka, M. Ayata, M. Ogawa, K. Fukuda, S. Maeda, H. Ogura, M. Shibata, Y. Ogura, T. Hayashi, and H. Taniguchi.
Organizer
112th General Meeting, The American Society for Microbiology.
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Lipid phenotypes of two distinct subpopulations of Mycobacterium bovisBacillus Calmette-Guerin Tokyo 172 substrain and their host responses.2012
Author(s)
T. Naka, S. Maeda, M. Niki, N. Ohara, S. Yamamoto, I. Yano, J. Maeyama, H. Ogura, K. Kobayashi, M. Shibata, and N. Fujiwara
Organizer
112th General Meeting, The American Society for Microbiology
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Comparative phenotypes in two subpopulations of Bacillus Calmette-Guerin (BCG) Tokyo 172 substrain.2011
Author(s)
T. Naka, S. Maeda, R. Yamamoto, M. Niki, N. Ohara, I. Yano, S. Yamamoto, J. Maeyama, H. Ogura, and N. Fujiwara
Organizer
International Unions of Microbiol- ogical Societies 2011 Congress.
Place of Presentation
Sapporo Convention Center, Sapporo, Hokkaido, Japan
Related Report
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[Presentation] Lung surfactant hydrolases alter the infection outcome of Mycobacterium tuberculosis in human macrophages2011
Author(s)
J. Arcos, S. Sasindran, N. Fujiwara, J.Turner, L. S. Schlesinger, and J. B. Torrelles
Organizer
Tuberculosis: Immun- ology, Cell Biology and Novel Vaccination Strategies, Part of the Keystone Symposia Global Health Series.
Place of Presentation
Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada
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