The structure and biosynthesis of glycopeptidolipid antigens from non-tureculous acid-fast bacteria, and their host responses

• Project/Area Number: 22590399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Osaka City University
• Principal Investigator: FUJIWARA Nagatoshi 大阪市立大学, 大学院・医学研究科, 講師 (80326256)
• Co-Investigator(Renkei-kenkyūsha): MAEDA Shinji 結核予防会結核研究所, 抗酸菌レファレンス部結核菌情報科, 科長 (50250212) ; YANO Ikuya 日本 BCG 製造株式会社中央研究所, 顧問 (60047008) ; NAKA Takashi 株式会社 MBR, 主任研究員 (40426599)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 構造・生理 / 非結核性抗酸菌症 / 宿主応答 / 脂質分子 / 感染症 / 非結核性抗酸菌 / 脂質 / 国際研究者交流、韓国 / 細菌 / 糖鎖

Research Abstract

Mycobacterium avium-intracellulare complex (MAC), which causes pulmonary and extrapulmonary diseases, is the most common isolate of nontuberculous mycobacteria. MAC species are classifiable into 28 serotypes according to the epitopic oligosaccharide struc

Research Products

• [Journal Article] Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance. (2013)
  • Author(s): N. Fujiwara, S.A. Porcelli, T. Naka, I. Yano, S. Maeda, H. Kuwata, S. Akira, S. Uematsu, T. Takii, H. Ogura, K. Kobayashi
  • Journal Title: Biochim. Biophys. Acta. Volume: 1831 Pages: 1177-1184
• [Journal Article] The mannan antigen lacking β-1,2-linked oligomannosides from Candida albicans increases production of inflammatory cytokines released by dendritic cells (2013)
  • Author(s): Ueno, K.
  • Journal Title: Med. Microbiol. Volume: 51 Issue: 4 Pages: 385-395
  • DOI: 10.3109/13693786.2012.733892
  • Peer Reviewed
• [Journal Article] Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance (2013)
  • Author(s): Fujiwara, N.
  • Journal Title: Biochim. Biophys. Acta. Volume: Mar 29 Issue: 6 Pages: 1177-84
  • DOI: 10.1016/j.bbalip.2013.03.008
  • Peer Reviewed
• [Journal Article] The polyketide synthaseassociated multidrug tolerance in Mycobacterium intracellulare clinical isolates (2012)
  • Author(s): I. Matsunaga, S. Meda, N. Nakata, N. Fujiwara
  • Journal Title: Chemotherapy Volume: 58(5) Pages: 341-348
• [Journal Article] Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density (2012)
  • Author(s): H. Yamada, A. Bhatt, R. Danev, N. Fujiwara, S. Maeda, S. Mitarai, K. Chikamatsu, A. Aono, K. Nitta, W.R. Jacobs Jr., K. Nagayama
  • Journal Title: Tuberculosis (Edinb) Volume: 92 Pages: 351-357
• [Journal Article] Characteristics of Mycobacterium smegmatis J15cs strain lipids (2012)
  • Author(s): N. Fujiwara, T. Naka, M. Ogawa, R. Yamamoto, H. Ogura, and H. Taniguchi
  • Journal Title: Tuberculosis (Edinb) Volume: 92 Pages: 187-192
• [Journal Article] Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates. (2012)
  • Author(s): Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki K.
  • Journal Title: Antimicrob Agents Chemother. Volume: 56(8) Issue: 8 Pages: 4140-5
  • DOI: 10.1128/aac.06445-11
  • Peer Reviewed
• [Journal Article] The polyketide synthase-associated multidrug tolerance in Mycobacterium intracellulare clinical isolates (2012)
  • Author(s): Matsunaga, I.
  • Journal Title: Chemotherapy Volume: 58 Issue: 5 Pages: 341-348
  • DOI: 10.1159/000343311
  • Peer Reviewed
• [Journal Article] The genus Enhydrobacter Staley et al.1987 should be recognized as a member of the family Rhodospirillaceae within the class Alphaproteobacteria (2012)
  • Author(s): Kawamura, Y
  • Journal Title: Microbiol.Immunol. Volume: 56 Pages: 21-6
  • Peer Reviewed
• [Journal Article] Characteristics of Mycobacterium smegmatis J15cs strain lipids (2012)
  • Author(s): Fujiwara, N.
  • Journal Title: Tuberculosis (Edinb) Volume: 92 Pages: 187-92
  • Peer Reviewed
• [Journal Article] Non-aid-fastness in M.tuberculosis ΔkasB mutant correlates with the cell envelope electron density (2012)
  • Author(s): Yamada, H.
  • Journal Title: Tuberculosis (Edinb) Volume: 286(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Lipid phenotype of two distinct subpopulations of Mycobacterium bovis Bacillus CalmetteGuerin Tokyo 172 substrain. (2011)
  • Author(s): T. Naka, S. Maeda, M. Niki, N. Ohara, S. Yamamoto, I. Yano, J. Maeyama, H. Ogura, K. Kobayashi, and N. Fujiwara
  • Journal Title: J. Biol. Chem. Volume: 286(51) Pages: 44153-44161
• [Journal Article] The structure and host recognition of serotype 13 glycopeptidolipid fromMycobacterium intracellulare (2011)
  • Author(s): T. Naka, N. Nakata, S. Maeda, R. Yamamoto, M. Doe, S. Mizuno, M. Niki, K. Kobayashi, H. Ogura, M. Makino, and N. Fujiwara
  • Journal Title: J. Bacterial. Volume: 193 Pages: 5766-5774
• [Journal Article] Human lung hydrolases delineate Mycobacterium tuberculosisMacrophage interactions and the capacity to control infection. (2011)
  • Author(s): J. Arcos, S. J. Sasindran, N. Fujiwara, J. Turner, L. S. Schlesinger, and J. B. Torrelles
  • Journal Title: J. Immunol. Volume: 187 Pages: 372-381
• [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity (2011)
  • Author(s): Komori T.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 16800-6
  • Peer Reviewed
• [Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs (2011)
  • Author(s): Hattori, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 409 Pages: 304-7
  • Peer Reviewed
• [Journal Article] Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection (2011)
  • Author(s): Arcos, J.
  • Journal Title: J.Immunol. Volume: 187 Pages: 372-81
  • Peer Reviewed
• [Journal Article] The structure and host recognition of serotype 13 glycopeptidolipid from Mycobacterium intracellulare (2011)
  • Author(s): Naka, T.
  • Journal Title: J.Bacterial. Volume: 193 Pages: 5766-74
  • Peer Reviewed
• [Journal Article] Branchiibius cervicis sp.nov., a novel species isolated from patients with atopic dermatitis (2011)
  • Author(s): Tomida, J.
  • Journal Title: Syst.Appl.Microbiol. Volume: 34 Pages: 503-7
  • Peer Reviewed
• [Journal Article] The lipid phenotype of two distinct subpopuiations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain (2011)
  • Author(s): Naka, T.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 44153-61
  • Peer Reviewed
• [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity. (2011)
  • Author(s): T.Komori
  • Journal Title: J.Biol.Chem. Volume: (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] A novel rhamnosyltransferase involved in the biosynthesis of serovar 4-specific glycolpeptidolipid from Mycobacterium aviumcomplex (2010)
  • Author(s): Y. Miyamoto, T. Mukai, T. Naka, N. Fujiwara, Y. Maeda, M. Kai, S. Mizuno, I. Yano, and M. Makino
  • Journal Title: J. Bacteriol Volume: 192 Pages: 5700-5708
• [Journal Article] Identification of Rhodococcus equi lipids recognized by host cytotoxic T lymphocytes (2010)
  • Author(s): S. P. Harris, N. Fujiwara, R. H. Mealey, D. C. Alperin, T. Naka, R. Goda, and S. A. Hines
  • Journal Title: Microbiology Volume: 156 Pages: 1836-1847
• [Journal Article] Identification of Rhodococcus equi lipids recognized by host cytotoxic T lymphocytes. (2010)
  • Author(s): S.P.Harris
  • Journal Title: Microbiology Volume: 156 Pages: 1836-1847
  • Peer Reviewed
• [Journal Article] A novel rhamnosyltransferase involved in the biosynthesis of serovar 4-specific glycopeptidolipid from Mycobacterium avium complex. (2010)
  • Author(s): Y.Miyamoto
  • Journal Title: J.Bacteriol. Volume: 192 Pages: 5700-5708
  • Peer Reviewed
• [Journal Article] The diversity of serotype-specific glycopeptidolipids from Mycobacterium avium-intracellulare complex isolated from patients. (2010)
  • Author(s): R.Goda
  • Journal Title: 相愛大学研究論集 Volume: 27 Pages: 91-97
• [Presentation] 抗酸菌における形態、宿主応答と連関した脂質生化学的一考察 (2013)
  • Author(s): 藤原永年、中崇、柴田満、前田伸司
  • Organizer: 第88回日本結核病学会総会
  • Place of Presentation: 千葉(幕張メッセ 国際会議場)
• [Presentation] MAC 菌 Ku11 株の天然型糖ペプチド脂質と宿主応答 (2013)
  • Author(s): 中崇、前田伸司、柴田満、水野淨子、藤原永年
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 千葉(幕張メッセ 国際会議場)
• [Presentation] 反復配列多型(VNTR)分析を利用した結核菌群の同定と型別 (2013)
  • Author(s): 前田伸司、中崇、藤原永年
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 千葉(幕張メッセ 国際会議場)
• [Presentation] Intact glycopeptidolipid from Mycobacterium intracellulare Ku11 and its host response (2013)
  • Author(s): 中崇
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] Production of anti-lipid IgG antibodies in BCG-immunized rabbit (2013)
  • Author(s): 柴田満
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] Identification and genotyping of Mycobacterium tuberculosis complex by VNTR (2013)
  • Author(s): 前田伸司
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] 抗酸菌における形態、宿主応答と連関した脂質生化学的一考察 (2013)
  • Author(s): 藤原永年
  • Organizer: 第88回日本結核病学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] BCGワクチン株の家兎免疫による脂質抗原に対するIgG抗体の産生とその性質 (2013)
  • Author(s): 柴田満
  • Organizer: 第88回日本結核病学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] 抗酸菌感染症におけるmacrophage inducible C-type lectin (mincle) の発現 (2013)
  • Author(s): 榊原ゆみ
  • Organizer: 第88回日本結核病学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] トリ型結核菌Mycobacterium avium のアミノ酸代謝とアンモニア産生に関する研究 (2013)
  • Author(s): 花村菜月
  • Organizer: 第88回日本結核病学会総会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉
• [Presentation] Candida albicansの細胞壁マンナンによる炎症性サイトカインの誘導-β-1,2-マンノシドの抑制的関与について- (2012)
  • Author(s): 上野圭吾
  • Organizer: 真菌症フォーラム第13回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-18
• [Presentation] Deletion of glycopeptidolipids in Mycobacterium smegmatis J15cs strain and its host responses. (2012)
  • Author(s): N. Fujiwara, T. Naka, M. Ayata, M. Ogawa, K. Fukuda, S. Maeda, H. Ogura, M. Shibata, Y. Ogura, T. Hayashi, and H. Taniguchi.
  • Organizer: 112th General Meeting, The American Society for Microbiology.
  • Place of Presentation: San Francisco, USA
• [Presentation] Lipid phenotypes of two distinct subpopulations of Mycobacterium bovisBacillus Calmette-Guerin Tokyo 172 substrain and their host responses. (2012)
  • Author(s): T. Naka, S. Maeda, M. Niki, N. Ohara, S. Yamamoto, I. Yano, J. Maeyama, H. Ogura, K. Kobayashi, M. Shibata, and N. Fujiwara
  • Organizer: 112th General Meeting, The American Society for Microbiology
  • Place of Presentation: San Francisco, USA
• [Presentation] Production and characterrization of polyclonal rabbit antibodies to mycobacterial lipid antigens. (2012)
  • Author(s): M. Shibata, T. Naka, S. Maeda, H. Ogura, and N. Fujiwara
  • Organizer: 112th General Meeting, The American Society for Microbiology.
  • Place of Presentation: San Francisco, USA
• [Presentation] Isolation of the phosphatidylserine synthetase knock-out mutants from mycobacteria, and their properties (2012)
  • Author(s): S. Maeda, N. Nakata, T. Naka, M. Kai, and N. Fujiwara
  • Organizer: 112th General Meeting, The American Society for Microbiology
  • Place of Presentation: San Francisco, USA
• [Presentation] BCG Tokyo 172 type I, II 株の形態及び脂質分子の分布と機能 (2012)
  • Author(s): 藤原永年、中崇、前田伸司、柴田満、仁木満美子、大原直也、前山順一、矢野郁也、山本三郎
  • Organizer: 第87回日本結核病学会総会
  • Place of Presentation: 広島(広島国際会議場)
• [Presentation] 臨床分離MAC菌の新規血清型特異糖ペプチド脂質抗原と宿主応答 (2012)
  • Author(s): 中崇、前田伸司、柴田満、水野淨子、藤原永年
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎(長崎ブリックホール)
• [Presentation] BCG Tokyo 172 type I, II株の形態及び脂質分子の分布と機能 (2012)
  • Author(s): 藤原永年
  • Organizer: 第87回日本結核病学会総会
  • Place of Presentation: 広島国際会議場、広島
• [Presentation] Mycobacterium avium 亜種（avium・hominissuis）間での酸性環境下における菌体外pH上昇に関与するアンモニア産生経路の研究 (2012)
  • Author(s): 花村菜月
  • Organizer: 第87回日本結核病学会総会
  • Place of Presentation: 広島国際会議場、広島
• [Presentation] Deletion of glycopeptidolipids in Mycobacterium smegmatis J15cs strain and its host responses (2012)
  • Author(s): Fujiwara, N.
  • Organizer: 112th General Meeting, The American Society for Microbiology
  • Place of Presentation: Moscone North & South, San Francisco, USA
• [Presentation] Lipid phenotypes of two distinct subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain and their host responses (2012)
  • Author(s): Naka, T.
  • Organizer: 112th General Meeting, The American Society for Microbiology
  • Place of Presentation: Moscone North & South, San Francisco, USA
• [Presentation] Isolation of the phosphatidylserine synthetase knock-out mutants from mycobacteria, and their properties (2012)
  • Author(s): Maeda, S.
  • Organizer: 112th General Meeting, The American Society for Microbiology
  • Place of Presentation: Moscone North & South, San Francisco, USA
• [Presentation] Production and characterization of polyclonal rabbit antibodies to mycobacterial lipid antigens (2012)
  • Author(s): Shibata, M.
  • Organizer: 112th General Meeting, The American Society for Microbiology
  • Place of Presentation: Moscone North & South, San Francisco, USA
• [Presentation] Mycobcterium avium subsp.hominissuis特異的菌体外pH上昇に関する研究 (2012)
  • Author(s): 小川翔大
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
• [Presentation] Novel glycopeptidolipid from clinically isolated Mycobacterium intra-cellulare and its host response (2012)
  • Author(s): Naka, N.
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
• [Presentation] Production and characteristics of anti-BCG-CWS IgG antibody in rabbit (2012)
  • Author(s): Shibata, M.
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
• [Presentation] Interaction between mycobacterial surface translocation and entry into non-phagocytic cells (2012)
  • Author(s): Okabe, M.
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
• [Presentation] マイコバクテリアのポリケチド合成酵素 Pks12 によるポリメチル脂肪酸の産生 (2011)
  • Author(s): 松永勇、前田伸司、中田登、中崇、藤原永年、杉田昌彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都(国立京都国際会館)
• [Presentation] Comparative phenotypes in two subpopulations of Bacillus Calmette-Guerin (BCG) Tokyo 172 substrain. (2011)
  • Author(s): T. Naka, S. Maeda, R. Yamamoto, M. Niki, N. Ohara, I. Yano, S. Yamamoto, J. Maeyama, H. Ogura, and N. Fujiwara
  • Organizer: International Unions of Microbiol- ogical Societies 2011 Congress.
  • Place of Presentation: Sapporo Convention Center, Sapporo, Hokkaido, Japan
• [Presentation] 臨床分離 MAC 菌の血清型特異糖ペプチド脂質抗原の分布と新規構造 (2011)
  • Author(s): 藤原永年、合田麗奈、佐藤明正、矢野郁也、前田伸司
  • Organizer: 第86回日本結核病学会総会
  • Place of Presentation: 東京(日本教育会館)
• [Presentation] Lung surfactant hydrolases alter the infection outcome of Mycobacterium tuberculosis in human macrophages (2011)
  • Author(s): J. Arcos, S. Sasindran, N. Fujiwara, J.Turner, L. S. Schlesinger, and J. B. Torrelles
  • Organizer: Tuberculosis: Immun- ology, Cell Biology and Novel Vaccination Strategies, Part of the Keystone Symposia Global Health Series.
  • Place of Presentation: Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada
• [Presentation] 臨床分離MAC菌の血清型特異糖ペプチド脂質抗原の分布と新規構造 (2011)
  • Author(s): 藤原永年
  • Organizer: 第86回日本結核病学会総会
  • Place of Presentation: 東京
• [Presentation] Comparative phenotypes in two subpopulations of Bacillus Calmette-Guerin (BCG) Tokyo 172 substrain (2011)
  • Author(s): Naka, T.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Systematic analysis of a novel taxonomic group in the family Flavobacteriaceae (2011)
  • Author(s): Tomida, J.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Production of ammonia by Mycobacterium avium in acidic condition (2011)
  • Author(s): Ogawa, S.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Biosynthesis of mycoketide and the related compounds in mycobacteria (2011)
  • Author(s): Matsunaga, I.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Establishment and characterization of knockout mutants of Mycobacterium bovis BCG gene involved in mycolic acid synthesis pathway (2011)
  • Author(s): Kai, M.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Characterization of a rpoZ mutant of Mycobacterium smegmatis (2011)
  • Author(s): Ogawa, M.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Sliding-defect mutants of Mycobacterium smegmatis have lower ability to entry into nonphagocytic cell (2011)
  • Author(s): Okabe, M.
  • Organizer: International Unions of Microbiological Societies 2011 Congress
  • Place of Presentation: Hokkaido, Japan
• [Presentation] マイコバクテリアのポリケチド合成酵素Pks12によるポリメチル脂肪酸の産生 (2011)
  • Author(s): 松永勇
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] Lung surfactant hydrolases alter the infection outcome of Mycobacterium tuberculosis in human macrophages. (2011)
  • Author(s): J.B.Torrelles
  • Organizer: Tuberculosis : Immunology, Cell Biology and Novel Vaccination Strategies, Part of the Keystone Symposia Global Health Series.
  • Place of Presentation: Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada.
• [Presentation] Comparable studies of immunostimulating activity and intracellular survivability in vitro among Mycobacterium bovis Bacillus Calmette-Guerin (BCG) substrains. (2011)
  • Author(s): D.Hayashi
  • Organizer: Tuberculosis : Immunology, Cell Biology and Novel Vaccination Strategies, Part of the Keystone Symposia Global Health Series.
  • Place of Presentation: Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada.
• [Presentation] BCG Toky 172株に存在するサブポピュレーション間の遺伝子発現の比較発現の比較検討 (2010)
  • Author(s): 大原直也
  • Organizer: 第80回実験結核研究会
  • Place of Presentation: 京都(京都テルサ)
  • Year and Date: 2010-05-19
• [Presentation] kasB KO結核菌の透過顕微鏡観察 (2010)
  • Author(s): 山田博之
  • Organizer: 第80回実験結核研究会
  • Place of Presentation: 京都(京都テルサ)
  • Year and Date: 2010-05-19
• [Presentation] BCG Tokyo 172 type I, II間の脂質生化学的比較 (2010)
  • Author(s): 藤原永年、前田伸司、吉村満美子、大原直也、前山順一、瀧井猛将、矢野郁也、山本三郎
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都(京都テルサ)
• [Presentation] Isolation and characterization of a rpoZ mutant of Mycobacterium smegmatis J15cs. (2010)
  • Author(s): H.Taniguchi
  • Organizer: Forty-fifth Tuberculosis And Leprosy Research Conference US-JAPAN Cooperative Medical Science Program.
  • Place of Presentation: Cambridge, Massachusetts USA.
• [Presentation] Analysis of RD16 locus in the BCG Tokyo 172 genome. (2010)
  • Author(s): N.Ohara
  • Organizer: Forty-fifth Tuberculosis And Leprosy Research Conference US-JAPAN Cooperative Medical Science Program.
  • Place of Presentation: Cambridge, Massachusetts USA.
• [Presentation] BCG Tokyo 172 type I,II間の脂質生化学的比較 (2010)
  • Author(s): 藤原永年
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都(京都テルサ)
• [Presentation] DNAマイクロアレイを用いたBCG Tokyo 172-1に存在するサブポピュレーションの遺伝子発現の比較検討 (2010)
  • Author(s): 大原直也
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都(京都テルサ)
• [Presentation] Novel serotype-specific glycopeptidolipid from clinically isolated Mycobacterium intracellulare. (2010)
  • Author(s): 合田麗奈
  • Organizer: 第83回日本生化学会大会 第33回日本分子生物学会年会 合同大会
  • Place of Presentation: 神戸(神戸ポートアイランド)
• [Presentation] Antibody production against serotype-nonspecific glycopeptidolipids from Mycobacterium avium. (2010)
  • Author(s): 松永勇
  • Organizer: 第83回日本生化学会大会 第33回日本分子生物学会年会 合同大会
  • Place of Presentation: 神戸(神戸ポートアイランド)
• [Book] Distribution, Characterization of Mycobacterial Glycolipids and Host Responses, Glycosylation (2012)
  • Author(s): Fujiwara, N.
  • Publisher: InTech
• [Book] Distribution, Characterization of Mycobacterial Glycolipids and Host Responses, Glycosilation (2012)
  • Author(s): Fujiwara, N.
  • Publisher: InTech
• [Book] BCG-Vaccine and Adjuvant (2011)
  • Author(s): Fujiwara, N., and I. Yano
  • Publisher: Japan Anti-Tuberculosis Association
• [Book] Anticancer immunotherapeutics : mycoloyl glycolipids and lipoglycan in the cell wall, BCG-Vaccine and Adjuvant(T.Takii, J.Maeyama, S.Yamamoto (ed.)) (2011)
  • Author(s): Fujiwara, N.
  • Publisher: Japan Anti-Tuberculosis Association