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Identification of novel toxin genes in CA-MRSA

Research Project

Project/Area Number 22590403
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionJuntendo University

Principal Investigator

HIRAMATSU Keiichi  順天堂大学, 医学部, 教授 (10173262)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsMRSA / leukocidin / CA-MRSA / HA-MRSA / PVL / MW1941 / MW1942 / Staphylococcus aureus / MW1941/MW1942 / 白血球溶解 / Leukocidin
Research Abstract

Community-acquired MRSA (CA-MRSA) has a stronger virulence than Healthcare-assiciated MRSA. Production of Panton-Valentine Leukocidin (PVL) is deemed to be responsible for the strong virulence.However, it was not clear that PVL alone could explain the strong virulence of CA-MRSA. We noticed that CA-MRSA strain MW2 produced another set of leukocidins MW1941/1942. We expressed the toxins in E. coli, purified the toxin proteins and measured their lytic activity against human leukocytes. We observed a synergistic lytic activity of PVL and MW1941/1942 against human leukocytes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2012 2011 Other

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] The pore-forming activities of Leukocidin/hemolysin toxin family proteins

    • Author(s)
      Isamu HONGO, Miki MATSUO , Shinya MIYAZAKI , Chikara KAITO, Teruyo ITO, Kazuhisa SEKIMIZU, and Keiichi HIRAMATSU
    • Journal Title

      MW1941 and MW1942 of community-acquired MRSA strain, MW2. Submitted to Microbes and Infection

    • Related Report
      2012 Final Research Report
  • [Presentation] USA400 MW2 株における新規白血球溶解毒素 MW1941 及び MW1942 の同定と好中球溶解活性2012

    • Author(s)
      本郷勇
    • Organizer
      第57回 日本ブドウ球菌研究会
    • Place of Presentation
      広島大学東京オフィス(東京都港区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of novel Leukocidin/hemolysin toxin family proteins, MW1941 and MW1942 in Staphylococcus aureus2011

    • Author(s)
      本郷勇
    • Organizer
      XIII International Congress of Bacteriology and Applied Microbiology (IUMS2011)
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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