| Project/Area Number |
22590409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Midori 産業医科大学, 医学部, 講師 (40320345)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | イノシトール / リン脂質 / 脂質生合成 / 結核 / 極性脂質 |
|---|
| Research Abstract |
We demonstrated a revised biosynthetic pathway for phosphatidylinositol (PI) in mycobacteria. Mycobacterial PI was synthesized from CDP-diacylglycerol (CDP-DAG) and inositol 1-phosphate via phosphatidylinositol phosphate (PIP), which was dephosphorylated to PI. PIP is not formed in the process of PI synthesis in humans because inositol reacts directly with CDP-DAG. PIP synthase in the pathway is a promising target for the development of new anti-mycobacterium drugs.
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