Role of Rab proteins and related host factors in HIV-1 assembly
Project/Area Number |
22590427
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
MURAKAMI Tsutomu 国立感染症研究所, エイズ研究センター, 室長 (50336385)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | Rab 蛋白質 / Rab蛋白質 / HIV-1 / 細胞内輸送 / 粒子形成 |
Research Abstract |
We hypothesized that some Rab proteins play roles in HIV-1 assembly and/or release. In the present study, we focused on Rab11, one of important regulators of recycling of cellular glycoproteins to the plasma membrane, and examined its potential roles in HIV-1 assembly. The results shown by the experiments using Rab11-kock down cells or cells that over-express Rab11 mutants suggest that Rab11 is involved in the formation of infectious virions by modulating trafficking of the HIV-1 Env glycoproteins.
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Report
(4 results)
Research Products
(10 results)