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Investigation of the defensive mechanisms of HIV-1 Vpu against the antiviral host factor BST-2

Research Project

Project/Area Number 22590428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TOKUNAGA Kenzo  国立感染症研究所, 感染病理部, 主任研究官 (50342895)

Co-Investigator(Renkei-kenkyūsha) TATSUMI Masashi  国立感染症研究所, エイズ研究センター, 室長 (00133629)
FUJITA Hideaki  九州大学, 薬学研究科, 助教 (80291524)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsHIV-1 / Vpu / BST-2 / 宿主因子
Research Abstract

HIV-1 Vpu enhances virion production by downregulating the antiviral host factor BST-2 from the cell surface. In this study, we attempted to identify host cofactors that play a supporting role in the anti-BST-2 activity of Vpu. We first prepared Vpu-binding proteins by performing immunoprecipitation assay, and identified multiple candidate proteins by proteome analyses. The candidate proteins were cloned into expression plasmids and then co-expressed with Vpu, followed by immunoprecipitation and subcellular localization assays. Knocking-down the gene expression of the candidate proteins that proved to interact with and colocalize with Vpu revealed no effect on Vpu’s anti-BST-2 activity, implying that those proteins might be involved in other functions of Vpu.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (86 results)

All 2013 2012 2011 2010 Other

All Journal Article (43 results) (of which Peer Reviewed: 38 results) Presentation (43 results)

  • [Journal Article] DNA damage aids HIV-1 infection of macrophages by overcoming integrase inhibition.2013

    • Author(s)
      Koyama, T., Sun, B., Tokunaga, K., Tatsumi, M., and Ishizaka, Y
    • Journal Title

      Retrovirology

      Volume: 10 Pages: 21-21

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins.2013

    • Author(s)
      Chutiwitoonchai, N., Hiyoshi, M., Hiyoshi-Yoshidomi, Y., Hashimoto, M., Tokunaga, K., and Suzu, S
    • Journal Title

      Microbes Infect

      Volume: 15 Pages: 280-90

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition.2013

    • Author(s)
      Koyama, T.
    • Journal Title

      Retrovirology

      Volume: 10 Issue: 1 Pages: 21-21

    • DOI

      10.1186/1742-4690-10-21

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins.2013

    • Author(s)
      Chutiwitoonchai, N.
    • Journal Title

      Microbes Infect.

      Volume: 15 Issue: 4 Pages: 280-90

    • DOI

      10.1016/j.micinf.2012.12.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.2013

    • Author(s)
      Fujita, H.
    • Journal Title

      J Cell Sci.

      Volume: in press

    • DOI

      10.1242/jcs.119909

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1 Vpu and BST-2/tetherin: Enemies at the Gates.2012

    • Author(s)
      Tokunaga, K
    • Journal Title

      Current HIV Res

      Volume: 10 Pages: 275-276

    • Related Report
      2012 Final Research Report
  • [Journal Article] Sites of action of HIV-1 Vpu in BST-2/tetherin downregulation.2012

    • Author(s)
      Arias, J.F., Iwabu, Y., and Tokunaga, K
    • Journal Title

      Current HIV Res

      Volume: 10 Pages: 283-291

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Logistics of BST-2/Tetherin.2012

    • Author(s)
      Fujita, H., Fujimoto, K., Tokunaga, K., and Tanaka, Y
    • Journal Title

      Current HIV Res

      Volume: 10 Pages: 321-326

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] proteins: No great escape from the magnificent seven.2012

    • Author(s)
      Arias, J.F., Koyama, T., Kinomoto, M., and Tokunaga, K
    • Journal Title

      Front Microbiol

      Volume: 3 Pages: 275-275

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host Restriction Factors in Retroviral Infection: Promises in Virus-Host Interaction.2012

    • Author(s)
      Zheng, Y.-H., Jeang, K.-T., and Tokunaga, K
    • Journal Title

      Retrovirology

      Volume: 9 Pages: 112-112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Editorial: HIV-1 Vpu and BST-2/tetherin: Enemies at the Gates.2012

    • Author(s)
      Tokunaga, K.
    • Journal Title

      Current HIV Res.

      Volume: 10 Pages: 275-6

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Sites of action of HIV-1 Vpu in BST-2/tetherin downregulation.2012

    • Author(s)
      Arias, J.F.
    • Journal Title

      Current HIV Res.

      Volume: 10 Pages: 283-91

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Logistics of BST-2/Tetherin.2012

    • Author(s)
      Fujita, H.
    • Journal Title

      Current HIV Res.

      Volume: 10 Pages: 321-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.2012

    • Author(s)
      Arias, J.F.
    • Journal Title

      Front Microbiol.

      Volume: 3 Pages: 56-62

    • DOI

      10.3389/fmicb.2012.00275

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host restriction factors in retroviral infection: promises in virus-host interaction.2012

    • Author(s)
      Zheng, Y.H.
    • Journal Title

      Retrovirology

      Volume: 9 Issue: 1 Pages: 112-112

    • DOI

      10.1186/1742-4690-9-112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Logistics of BST-2/Tetherin2012

    • Author(s)
      Fujita, H., Fujimoto, K., Tokunaga, K., Tanaka, Y.
    • Journal Title

      Current HIV Res.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sites of action of HIV-1 Vpu in BST-2/tetherm downregulation2012

    • Author(s)
      Arias, J.A., Iwabu, Y., Tokunaga, K(corresponding author)
    • Journal Title

      Current HIV Res.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Editorial-HIV-1 Vpu and BST-2/tetherin : Enemies at the Gates2012

    • Author(s)
      Tokunaga, K.(Guest Editor)
    • Journal Title

      Current HIV Res.

      Volume: (編集後記)(in press)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] protein complex 2 alpha 1 subunit-mediated regulation of human immunodeficiency virus type 1 replication.2011

    • Author(s)
      Sapsutthipas, S., Kitagawa, Y., Tokunaga, K., Ikuta, K., and Kameoka, M
    • Journal Title

      Southeast Asian J. Trop. Med. Public Health.

      Volume: 42 Pages: 311-319

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1感染阻害因子(HIV-1 Restriction Factors)2011

    • Author(s)
      徳永研三、足立昭夫、高折晃史、中山英美、岩部幸枝、岩谷靖雄
    • Journal Title

      日本エイズ学会誌 The Journal of AIDS Research.

      Volume: 13 Pages: 56-62

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of SNF2h, a Chromatin-Remodeling Factor, as a Novel Binding Protein of Vpr of Human Immunodeficiency Virus Type 1.2011

    • Author(s)
      Taneichi, D., Iijima, K., Doi, A., Koyama, T., Minemoto, Y., Tokunaga, K., Shimura, M., and Ishizaka, Y
    • Journal Title

      J. Neuroimmune Pharm

      Volume: 6 Pages: 177-87

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.2011

    • Author(s)
      Ikeda, T., Abd El Galil, K., Tokunaga, K., Maeda, K., Sata, T., Sakaguchi, N., Harada, S., Heidmann, T., and Koito, A
    • Journal Title

      Nucleic Acids Res

      Volume: 39 Pages: 5538-5554

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.2011

    • Author(s)
      Shimura, M., Toyoda, Y., Iijima, K., Kinomoto, M, Tokunaga, K., Yoda, K., Yanagida, M., Sata, T., and Ishizaka, Y
    • Journal Title

      J. Cell Biol

      Volume: 194 Pages: 721-35

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for antiviral activity of BST-2/tetherin and its viral antagonisms.2011

    • Author(s)
      Arias, J.F., Iwabu, Y., and Tokunaga, K
    • Journal Title

      Front Microbiol

      Volume: 2 Pages: 250-250

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of SNF2h, a Chromatin-Remodeling Factor, as a Novel Binding Protein of Vpr of Human Immunodeficiency Virus Type 12011

    • Author(s)
      Taneichi, D., Iijima, K., Doi, A., Koyama, T., Minemoto, Y., Tokunaga, K., Shimura, M., Ishizaka, Y.
    • Journal Title

      J.Neuroimmune Pharm.

      Volume: 6 Issue: 2 Pages: 177-87

    • DOI

      10.1007/s11481-011-9276-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral factors involved in adapter-related protein complex 2 alpha 1 subunit-mediated regulation of human immunodeficiency virus type 1 replication2011

    • Author(s)
      Sapsutthipas, S., Kitagawa, Y., Tokunaga, K., Ikuta, K., Kameoka, M.
    • Journal Title

      Southeast Asian J.Trop.Med.Public Health.

      Volume: 42 Pages: 311-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons2011

    • Author(s)
      Ikeda, T., Abd El Galil, K., Tokunaga, K., Maeda, K., Sata, T., Sakaguchi, N., Harada, S., Heidmann, T., Koito, A.
    • Journal Title

      Nucleic Acids Res

      Volume: 39 Issue: 13 Pages: 5538-54

    • DOI

      10.1093/nar/gkr124

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation2011

    • Author(s)
      Shimura, M., Toyoda, Y., Iijima, K., Kinomoto, M, Tokunaga, K., Yoda, K., Yanagida, M., Sata, T., Ishizaka, Y.
    • Journal Title

      J.Cell Biol.

      Volume: 194 Issue: 5 Pages: 721-35

    • DOI

      10.1083/jcb.201010118

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for antiviral activity of BST-2/tetherin and its viral antagonisms2011

    • Author(s)
      Arias, J.A., Iwabu, Y., Tokunaga, K(corresponding author)
    • Journal Title

      Front.Microbiol.

      Volume: 2 Pages: 250-250

    • DOI

      10.3389/fmicb.2011.00250

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1感染阻害因子(HIV-1 Restriction Factors)2011

    • Author(s)
      徳永研三、足立昭夫、高折晃史、中山英美、岩部幸枝、岩谷靖雄
    • Journal Title

      日本エイズ学会誌The Journal of AIDS Research

      Volume: 13 Pages: 56-62

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.2011

    • Author(s)
      Ikeda, T., Abd El Galil K., Tokunaga, K., Maeda, K., Sata, T., Sakaguchi, N., Harada, S., Heidmann, T., Koito, A.
    • Journal Title

      Nucleic Acids Res.

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of SNF2h, a Chromatin-Remodeling Factor, as a Novel Binding Protein of Vpr of Human Immunodeficiency Virus Type 1.2011

    • Author(s)
      Taneichi, D., Iijima, K., Doi, A., Koyama, T., Minemoto, Y., Tokunaga, K., Shimura, M., Ishizaka, Y.
    • Journal Title

      J.Neuroimmune Pharm.

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two N-linked glycosylation sites in V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for CD4 binding domain.2010

    • Author(s)
      Utachee, P., Nakamura, S., Isarangkura-na-ayuthaya, P., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit, W., and Kameoka, M
    • Journal Title

      J. Virol

      Volume: 84 Pages: 4311-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors.2010

    • Author(s)
      Mitsuishi, T., Iwabu, Y., Tokunaga, K., Sata, T., Kaneko, T., Ohara, K., Ohsawa, I., Oda, F., Kato, T., Yamada, Y., Kawana, S., Ozaki, K., Nakatake, M., and Yamada, O
    • Journal Title

      BMC cancer

      Volume: 10 Pages: 118-118

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BST-2/tetherin by the HIV-1 accessory protein Vpu2010

    • Author(s)
      Iwabu, Y., Fujita, H., Tanaka, Y., Sata, T., and Tokunaga, K
    • Journal Title

      Commun. Integr. Biol

      Volume: 3 Pages: 366-369

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of lysine residue at amino acid position 165 of human immunodeficiency virus type 1 CRF01_AE Gag in reducing viral drug susceptibility to protease inhibitors.2010

    • Author(s)
      Kameoka, M, Isarangkura-na-ayuthaya, P., Kameoka, Y., Sapsutthipas, S., Soonthornsata, B., Nakamura, S., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., and Auwanit, W.
    • Journal Title

      Virology

      Volume: 405 Pages: 129-38

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.2010

    • Author(s)
      Iwabu, Y., Kinomoto, M., Tatsumi, M., Fujita, H., Shimura, M., Tanaka, Y., Ishizaka, Y., Nolan, D., Mallal, S., Sata, T., and Tokunaga, K (corresponding author)
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 35350-35358

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two N-linked glycosylation sites in V2 and C2 regions of human immunodeficiency virus type 1 CRFO1_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for CD4 binding domain.2010

    • Author(s)
      Utachee, P., Nakamura, S., Isarangkura-na-ayuthaya, P., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit W., Kameoka, M.
    • Journal Title

      J.Virol.

      Volume: 84 Pages: 4311-4320

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined analysis of cell growth and apoptosis-regulating proteins in HPVsassociated anogenital tumors.2010

    • Author(s)
      Mitsuishi, T., Iwabu, Y., Tokunaga, K., Sata, T., Kaneko, T., Ohara, K., Ohsawa, I., Oda, F., Kato, T., Yamada, Y., Kawana, S., Ozaki, K., Nakatake, M., Yamada, O.
    • Journal Title

      BMC cancer

      Volume: 10 Pages: 118-118

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct internalization of cell-surface BST-2/tetherin by the HIV-1 accessory protein Vpu.2010

    • Author(s)
      Iwabu, Y., Fujita, H., Tanaka, Y., Sata, T., Tokunaga, K(corresponding author).
    • Journal Title

      Commurr.Integr.Biol.

      Volume: 3 Pages: 366-369

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of lysine residue at amino acid position 165 of human immunodeficiency virus type 1 CRF01_AE Gag in reducing viral drug susceptibility to protease inhibitors.2010

    • Author(s)
      Kameoka, M., Isarangkura-na-ayuthaya, P., Kameoka, Y., Sapsutthipas, S., Soonthornsata, B., Nakamura, S., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit, W.
    • Journal Title

      Virology

      Volume: 405 Pages: 129-138

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived fromdifferent subtypes.2010

    • Author(s)
      Iwabu, Y., Kinomoto, M., Tatsumi, M., Fujita, H., Shimura, M., Tanaka, Y., Ishizaka, Y., Nolan, D., Mallal, S., Sata, T., Tokunaga, K(corresponding author).
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 35350-35358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.

    • Author(s)
      Fujita, H., Iwabu, Y., Tokunaga, K., and Tanaka, Y
    • Journal Title

      J. Cell Sci.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Anti-APOBEC3G activity of HIV-1 Vif protein from elite controllers is attenuated compared to those from untreated chronic progressors or those from individuals with acute infection.2012

    • Author(s)
      T. Kikuchi, Y. Iwabu, A. Kawana- Tachikawa, M. Koga, N. Hosoya, S. Nomura1, Z.L. Brumme, H. Jessen, A. Kelleher, M. Markowitz, F. Pereyra, A. Trocha, B.D. Walker, A. Iwamoto, K. Tokunaga, and T. Miura
    • Organizer
      XIX International AIDS Conference
    • Place of Presentation
      Washington D.C., USA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] HIV-1感染者における抗ウイルス宿主因子の発現レベルと病態進行との相関性の有無2012

    • Author(s)
      張 延昭、岩部幸枝、立川(川名) 愛、中村仁美、David Nolan、Simon Mallal、長谷川秀樹、山岡昇司、岩本愛吉、徳永研三
    • Organizer
      第59回日本ウイルス学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV-2 Vpxに不活化される抗ウイルス宿主因子の探索2012

    • Author(s)
      小山貴芳、Juan F. Arias、岩部幸枝、徳永研三
    • Organizer
      第59回日本ウイルス学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] APOBEC3GによるAlu転移抑制の分子生物学的および構造学的解析2012

    • Author(s)
      Juan F. Arias、小山貴芳、岩部幸枝、横山勝、佐藤裕徳、長谷川秀樹、徳永研三
    • Organizer
      第59回日本ウイルス学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV-1 elite controllerにおけるHIV-1 Vifの抗APOBEC3G活性の低下2012

    • Author(s)
      菊地正、岩部幸枝、立川(川名)愛、古賀道子、野村滋、細谷紀彰、Zabrina L. Brumme、Heiko Jessen、Anthony D. Kelleher、Martin Markowitz、Florencia Pereyra、Alicja Trocha、Bruce D. Walker、岩本愛吉、徳永研三、三浦聡之
    • Organizer
      第59回日本ウイルス学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] APOBEC3Gの抗Aluレトロ転移活性に寄与するアミノ酸の同定2012

    • Author(s)
      小山貴芳、Juan F Arias、横山勝、佐藤裕徳、徳永研三
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV-1感染者における抗ウイルス宿主因子の発現レベルと病態進行との相関性の有無.2012

    • Author(s)
      張延昭
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] HIV-2 Vpxに不活化される抗ウイルス宿主因子の探索.2012

    • Author(s)
      小山貴芳
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] APOBEC3GによるAlu転移抑制の分子生物学的および構造学的解析.2012

    • Author(s)
      徳永研三
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] HIV-1 elite controllerにおけるHIV-1 Vifの抗APOBEC3G活性の低下.2012

    • Author(s)
      菊地正
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] APOBEC3Gの抗Aluレトロ転移活性に寄与するアミノ酸の同定.2012

    • Author(s)
      小山貴芳
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Infectivity of HIV-1 Subtypes Isolated from Ghanaian Patients.2011

    • Author(s)
      Barnor, J., Tatsumi, M., Sata, T., Ampofo, W., Osei-Kwasi, M., Tokunaga, K
    • Organizer
      Patients.WSU Joint International Conference. East London
    • Place of Presentation
      South Africa
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV-1 DNA integration into host chromosomal double-strand break sites is not attenuated by raltegravir, an integrase inhibitor.2011

    • Author(s)
      Takayoshi Koyama, Kenzo Tokunaga, Tetsutaro Sata, Yukihito Ishizaka
    • Organizer
      IUMS 2011
    • Place of Presentation
      Sapporo, Japan,
    • Related Report
      2012 Final Research Report
  • [Presentation] 膜結合型ユビキチンリガーゼMARCH8によるトランスフェリン受容体のユビキチン化およびダウンレギュレーションの分子機構2011

    • Author(s)
      藤田英明、岩部幸枝、佐多徹太郎、徳永研三、田中嘉孝
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Homodimerization of APOBEC3G is required for inhibition of Alu retrotransposition.2011

    • Author(s)
      Yukie Iwabu, Juan F. Arias, Masaru Yokoyama, Hironori Sato, Tetsutaro Sata and Kenzo Tokunaga
    • Organizer
      Frontiers of Retrovirology Conference 2011,
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV-1 integraion into host DNA double-strand break sites is the majority event in integrase inhibitor-treated cells.2011

    • Author(s)
      Takayoshi Koyama, Kenzo Tokunaga, Yukihito Ishizaka
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Infectivity of HIV-1 Subtypes Isolated from Ghanaian Patients2011

    • Author(s)
      Nii-Trebi, N., Kinomoto, M., Brandful, J., Barnor, J., Tatsumi, M., Sata, T., Ampofo, W., Osei-Kwasi, M., Tokunaga, K.
    • Organizer
      WSU Joint International Conference
    • Place of Presentation
      East London, South Africa
    • Related Report
      2011 Annual Research Report
  • [Presentation] HIV-1 DNA integration into host chromosomal double-strand break sites is not attenuated by raltegravir, an integrase inhibitor2011

    • Author(s)
      Takayoshi Koyama, Kenzo Tokunaga, Tetsutaro Sata, Yukihito Ishizaka
    • Organizer
      IUMS 2011
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Homodimerization of APOBEC3G is required for inhibition of Aluretrotransposition2011

    • Author(s)
      Yukie Iwabu, Juan F.Arias, Masaru Yokoyama, Hironori Sato, Tetsutaro Sata, Kenzo Tokunaga
    • Organizer
      Frontiers of Retrovirology Conference 2011
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2011 Annual Research Report
  • [Presentation] HIV-1 integraion into host DNA double-strand break sites is the majority event in integrase inhibitor-treated cells2011

    • Author(s)
      Takayoshi Koyama, Kenzo Tokunaga, Yukihito Ishizaka
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Direct internalization of cell-surface BST-2/tetherin by HIV-1 Vpu.2010

    • Author(s)
      Yukie Iwabu, Hideaki Fujita, Yoshitaka Tanaka, Tetsutaro Sata, and Kenzo Tokunaga
    • Organizer
      Centennial Retroviruses Meeting (CRM2010)
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Final Research Report
  • [Presentation] Integration into DNA double-strand break sites of HIV-1 is not attenuated by raltegravir, an integrase inhibitor.2010

    • Author(s)
      akayoshi Koyama, Kenzo Tokunaga, Tetsutaro Sata, Yukihito Ishizaka
    • Organizer
      11th Kumamoto AIDS Seminar Global COE Joint International Symposium
    • Place of Presentation
      Kumamoto
    • Related Report
      2012 Final Research Report
  • [Presentation] Battles between Host and Viruses: Molecular Mechanisms of the Inactivation of Antiviral Host Factors by HIV-1 Accessory Proteins2010

    • Author(s)
      Kenzo Tokunaga
    • Organizer
      National Institute of Health, Thailand.
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Final Research Report
  • [Presentation] Targeting of recycling endosomes to the cleavage furrow requires ubiquitylation of membrane proteins.2010

    • Author(s)
      Hideaki Fujita, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Keiko Fujimoto, Ryo Tachiyama, Daisuke Ishikawa, Masaki Matsumoto, Keiichi I Nakayama, and Yoshitaka Tanaka
    • Organizer
      Biochemistry and Cell Biology of ESCRTs in Health and Disease (ASBMB Special Meeting)
    • Place of Presentation
      Utah, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV-1 VpuによるBST-2/tetherinの機能阻害に関与するcofactorの検索2010

    • Author(s)
      岩部幸枝、藤田英明、田中嘉孝、佐多徹太郎、徳永研三
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] HIV-1 Vpuによる細胞表面BST-2/tetherinの直接的なinternalization2010

    • Author(s)
      徳永研三、岩部幸枝、藤田英明、田中嘉孝、佐多徹太郎
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] CRF01_AE Gag 165番目のリジン残基がプロテアーゼ阻害剤に対するウイルスの薬剤感受性を低下させる分子機構2010

    • Author(s)
      亀岡正典、Panasda Isarangkura-na- ayuthaya、亀岡陽子、Sompong Sapsutthipas、Bongkot Soonthornsata、中村昇太、徳永研三、Pathom Sawanpanyalert、生田和良、Wattana Auwanit
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] Two N-linked glycosylation sites in Env gp120 regulate the susceptibility of CRF01_AE viruses to the CD4 binding domain antibody, IgG1 b12.2010

    • Author(s)
      Piraporn Utachee、中村昇太、Panasda Isarangkura-na-ayuthaya、徳永研三、Pathom Sawanpanyalert、生田和良、Wattana Auwanit、亀岡正典
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] 哺乳類APOBEC1による内在性レトロエレメント制御機構の解析2010

    • Author(s)
      池田輝政、Abd El Galil Khaled Hussein、徳永研三、前田和彦、佐多徹太郎、阪口薫雄、Thierry Heidman、小糸厚
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] BST-2/tetherin2010

    • Author(s)
      岩部幸枝,佐多徹太郎,徳永研三
    • Organizer
      第24回日本エイズ学会シンポジウム[Restriction Factor]
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] APOBEC3Gの抗Aluレトロ転移活性に関わる責任領域の同定2010

    • Author(s)
      岩部幸枝,佐多徹太郎,徳永研三
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] BST-2/tetherinのdownregulationにおけるHIV-1 Vpuのcofactor要求性2010

    • Author(s)
      岩部幸枝、藤田英明、田中嘉孝、佐多徹太郎、徳永研三
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] The endosomal vesicles carrying ubiquitylated cargos selectively localizes to the cleavage furrow during cytokinesis2010

    • Author(s)
      Hideaki Fujita, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Keiko Fujimoto, Ryo Tachiyama, Daisuke Ishikawa, Masaki Matsumoto, Keiichi I Nakayama, and Yoshitaka Tanaka
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Site-Specific Integration of a Lentiviral Vector in the Human Genome via DNA Double-Strand Breaks.2010

    • Author(s)
      Takayoshi Koyama, Kenzo Tokunaga, Tetsutaro Sata, Yukihito Ishizaka
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Direct internalization of cell-surface BST-2/tetherin by HIV-1 Vpu.2010

    • Author(s)
      Yukie Iwabu, Hideaki Fujita, Yoshitaka Tanaka, Tetsutaro Sata, Kenzo Tokunaga (presenter)
    • Organizer
      Centennial Retroviruses Meeting (CRM2010)
    • Place of Presentation
      Prague, Czech Republic.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Battles between Host and Viruses : Molecular Mechanisms of the Inactivation of Antiviral Host Factors by HIV- 1 Accessory Proteins.2010

    • Author(s)
      Kenzo Tokunaga
    • Organizer
      Thai NIH Seminar
    • Place of Presentation
      Thailand.Bangkok
    • Related Report
      2010 Annual Research Report
  • [Presentation] Targeting of recycling endosomes to the cleavage furrow requires ubiquitylation of membrane proteins.2010

    • Author(s)
      Hideaki Fujita, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Keiko Fujimoto, Ryo Tachiyama, Daisuke Ishikawa, Masaki Matsumoto, Keiichi I Nakayama, Yoshitaka Tanaka.
    • Organizer
      Biochemistry and Cell Biology of ESCRTs in Health and Disease (ASBMB Special Meeting)
    • Place of Presentation
      Utah, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIV-1 Vpuによる細胞表面BST-2/tetherinの直接的なinternalization.2010

    • Author(s)
      徳永研三、岩部幸枝、藤田英明、田中嘉孝、佐多徹太郎
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] CRFO1_AE Gag 165番目のリジン残基がプロテアーゼ阻害剤に対するウイルスの薬剤感受性を低下させる分子機構2010

    • Author(s)
      亀岡正典、Panasda Isarangkura-na-ayuthaya、亀岡陽子、Sompong Sapsutthipas、Bongkot Soonthornsata、中村昇太、徳永研三、Pathom Sawanpanyalert、生田和良、Wattana Auwanit
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two N-linked glycosylation sites in Env gp 120 regulate the susceptibility of CRF01_AE viruses to the CD4 binding domain antibody, IgGl b12.2010

    • Author(s)
      Piraporn Utachee、中村昇太、Panasda Isarangkura-na-ayuthaya、徳永研三、Pathom Sawanpanyalert、生田和良、Wattana Auwanit、亀岡正典
    • Organizer
      第58回日本ウイルス学会総会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] BST-2/tetherin.2010

    • Author(s)
      岩部幸枝, 佐多徹太郎, 徳永研三
    • Organizer
      第24回日本エイズ学会シンポジウム[Restriction Factor]
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] BST-2/tetherinのdownregulationにおけるHIV-1Vpuのcofactor要求性2010

    • Author(s)
      岩部幸枝、藤田英明、田中嘉孝、佐多徹太郎、徳永研三
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] The endosomal vesicles carrying ubiquitylated cargos selectively localizes to the cleavage furrow during cytokinesis.2010

    • Author(s)
      Hideaki Fujita, Yukie Iwabu, Kenzo Tokunaea, Tetsutaro Sata, Keiko Fujimoto, Ryo Tachiyama, Daisuke Ishikawa, Masaki Matsumoto, Keiichi I Nakayama, Yoshitaka Tanaka
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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