Development of the method for reducing the adverse effect of arsenic trioxide

• Project/Area Number: 22590504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Jichi Medical University
• Principal Investigator: FUJIMURA Akio 自治医科大学, 医学部, 教授 (90156901)
• Co-Investigator(Renkei-kenkyūsha): KOSHIMIZU Takaaki 自治医科大学, 医学部, 准教授 (20392491) ; KUMASAKI Msafumi 自治医科大学, 大学院・医学部, 博士課程 (50547966)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 臨床薬理学 / 有害反応 / 薬理学 / QT延長 / 白血病

Research Abstract

We investigated whether α-lipoic acid reduces the cardiotoxicity of arsenic trioxide, an effective medication for acute promyelocytic leukemia, in animal models. Co-treatment with α-lipoic acid attenuated ECG abnormalities acutely caused by a single dose

Research Products

• [Journal Article] α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs (2013)
  • Author(s): Kumazaki M, Ando H, Kakei M, Ushi j ima K, Taniguchi Y, Yoshida M, Yamato S, Washino S, Koshimizu TA, Fujimura A
  • Journal Title: Eur J Pharmacol Volume: 705 Pages: 1-10
  • Peer Reviewed
• [Journal Article] α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. (2013)
  • Author(s): Kumazaki M
  • Journal Title: Eur J Pharmacol Volume: 705 Issue: 1-3 Pages: 1-10
  • DOI: 10.1016/j.ejphar.2013.02.027
  • Peer Reviewed
• [Journal Article] Protective Effect of .ALPHA.-Lipoic Acid Against Arsenic Trioxide-Induced Acute Cardiac Toxicity in Rats (2011)
  • Author(s): Kumazaki M, Ando H, Sasaki A, Koshimizu TA, Ushijima K, Hosohata K, Oshima Y, Fujimura A
  • Journal Title: Journal of Pharmacological Sciences Volume: 115 Issue: 2 Pages: 244-248
  • DOI: 10.1254/jphs.10280SC
  • NAID: 10029892273
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Protective Effect of α-Lipoic Acid Against Arsenic Trioxide-Induced Acute Cardiac Toxicity in Rats (2011)
  • Author(s): Masafumi Kumazaki
  • Journal Title: J Pharmacol Sci Volume: 115 Pages: 244-8
  • Peer Reviewed
• [Presentation] トキシコゲノミクス研究による毒性発現機序の解明とその対処法の探索 (2010)
  • Author(s): 藤村昭夫
  • Organizer: 第31回日本臨床薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-12-01