Development of the method for reducing the adverse effect of arsenic trioxide
Project/Area Number |
22590504
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
|
Research Institution | Jichi Medical University |
Principal Investigator |
FUJIMURA Akio 自治医科大学, 医学部, 教授 (90156901)
|
Co-Investigator(Renkei-kenkyūsha) |
KOSHIMIZU Takaaki 自治医科大学, 医学部, 准教授 (20392491)
KUMASAKI Msafumi 自治医科大学, 大学院・医学部, 博士課程 (50547966)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 臨床薬理学 / 有害反応 / 薬理学 / QT延長 / 白血病 |
Research Abstract |
We investigated whether α-lipoic acid reduces the cardiotoxicity of arsenic trioxide, an effective medication for acute promyelocytic leukemia, in animal models. Co-treatment with α-lipoic acid attenuated ECG abnormalities acutely caused by a single dose
|
Report
(4 results)
Research Products
(5 results)