A novel therapy using histone deacetylase inhibitors for Duchenne muscular dystrophy.

• Project/Area Number: 22590509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Sojo University
• Principal Investigator: UCHIDA Yuji 崇城大学, 薬学部, 准教授 (70433026)
• Co-Investigator(Kenkyū-buntansha): KIMURA En 独立行政法人国立精神・神経医療研究センター, トランスレーショナルメディカル センター 臨床研究支援部 早期・探索的 臨床試験室, 室長 (60433025)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 筋ジストロフィー / 筋疾患 / 薬物治療

Research Abstract

We have examined the possibility ofnovael therapy using histone deacetylase inhibitors(HDAC-I) for muscel differentiation. At first, we have investigated the changeof C2C12 cells (mouse myoblast cell line) after the administration of TSA. We have not observed the efficacy of TSA. Next,we have used retinoid(Am80). However,we have obtainedno distinct effects on C2C12 cells.

Research Products

• [Presentation] Muscle fiber type-predominant promoter activity in lentiviral-mediated transgenic mouse. (2011)
  • Author(s): Tomohiro, Suga, En Kimura, Yuka, Morioka Masahito Ikawa, Sheng Li, Katsuhisa Uchino, Yuji Uchida (Sojo Universit y), Satoshi Yamashita, Yasushi Maeda, J S Chamberlain (University of Washington School of Medicine)
  • Organizer: Makoto Uchino.
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-05-18
• [Presentation] Lentiviral vector mediated delivery of full-length dystrophin for gene therapy of muscular dystrophy. (2010)
  • Author(s): En Kimura, Katsuhisa Uchino , Tomohiro Suga, Tatsuya Koide Yuji Uchida (Sojo University), Yasushi Maeda, SatoshiYamashita, Jeffrey Chamberlain
  • Organizer: Makoto Uchino
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2010-10-12
• [Presentation] 筋ジストロフィーの遺伝子・幹細胞治療研究 (2010)
  • Author(s): 内野克尚, 木村 円, 菅 智宏, 小出達也, 内田友二(崇城大学), 山下 賢, 前田 寧jeffrey S. Chamberlain (University of Washington School of Medicine),内野 誠.
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] Lentiviral vector mediated delivery of full-length dystrophin for gene therapy of muscular dystrophy. (2010)
  • Author(s): En Kimura, Katsuhisa Uchino , Tomohiro Suga, Tatsuya Koide , Yuji Uchida
  • Organizer: ASGCT 13th Annual Meeting
  • Place of Presentation: Washington,D.C.,USA.
  • Year and Date: 2010-05-17