| Project/Area Number |
22590520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OSADA Makoto 山梨大学, 医学部附属病院, 臨床検査技師 (20569628)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Osamu 山梨大学, 医学工学総合研究部, 助教 (00432154)
OZAKI Yukio 山梨大学, 医学工学総合研究部, 教授 (30134539)
INOUE Katsue 山梨大学, 医学工学総合研究部, 准教授 (10324211)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 臨床検査医学 / sCLEC-2 / 血小板 / 動脈血栓 / ELISA / SCLEC-2 / 動脈血栓症 |
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| Research Abstract |
We hypothesized that concentration of plasma soluble CLEC-2 is a good marker for platelet activation in vivo and that it could be a useful biomarker for prevention and treatment for myocardial and cerebral infarction. We established ELISA system to measure sCLEC-2 and found that sCLEC-2 isgenerated upon platelet activation. Moreover, plasma sCLEC-2 is significantly increased in patients of acute coronary syndrome, suggesting that sCLEC-2 is a useful biomarker for prevention and treatment for arterial thrombosis.
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