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Study of lipid hydroperoxides in metabolic syndrome

Research Project

Project/Area Number 22590534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionHokkaido University

Principal Investigator

HUI Shu-ping  北海道大学, 大学院・保健科学研究院, 准教授 (90337030)

Co-Investigator(Kenkyū-buntansha) 黒澤 隆夫  北海道医療大学, 薬学部, 教授 (50103198)
千葉 仁志  北海道大学, 大学院・保健科学研究院, 教授 (70197622)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords臨床化学 / 過酸化脂質 / Lipid hydroperoxide / 酸化リポ蛋白 / 免疫 / 分析化学
Research Abstract

Cholesterylester monohydroperoxides (CEOOH), triglyceride monohydroperoxides (TGOOH, and phosphatidylcholine monohydroperoxide (PCOOH) were chemically synthesized. oxLDL was prepared by incubating native LDL from human plasma with CuSO4 for up to 4 h. The PCOOH levels during oxidation were determined and showed time course consisted of three phases. We then immunized five mice using the synthetic PCOOH and oxLDL, and antibody titers were measured. For synthetic PCOOH, the antibody titer did not show increase, but significant increase for oxLDL.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (101 results)

All 2013 2012 2011 2010

All Journal Article (27 results) (of which Peer Reviewed: 25 results) Presentation (73 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Analysis of triacylglycerol hydroperoxides in human lipoproteins by Orbitrap mass spectrometer.2013

    • Author(s)
      Hui SP, Sakurai T, Takeda S, Jin S, Fuda H, Kurosawa T, Chiba H.
    • Journal Title

      Anal Bioanal Chem

      Volume: 405 Pages: 4981-87

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of various electrode materials for detection of oxidized low-density lipoproteins.2013

    • Author(s)
      Takeda S, Hui SP, Fukuda K, Fuda H, Jin S, Sakurai T, Ishii A, Mukasa K, Sueoka K, Chiba H.
    • Journal Title

      J Biomed Nanotech

      Volume: 9 Pages: 303-306

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of triacylglycerol hydroperoxides in human lipoproteins by Orbitrap mass spectrometer2013

    • Author(s)
      Hui SP et al.
    • Journal Title

      Anal Bioanal Chem

      Volume: 405 Issue: 14 Pages: 4981-4987

    • DOI

      10.1007/s00216-013-6903-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection and characterization of cholesteryl ester hydroperoxides in oxidized LDL and oxidized HDL by use of an Orbitrap mass spectrometer.2012

    • Author(s)
      Hui SP, Sakurai T, Ohkawa F, Furumaki H, Jin S, Fuda H, Takeda S, Kurosawa T, Chiba H.
    • Journal Title

      Anal Bioanal Chem

      Volume: 404 Pages: 101-112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative determination of phosphatidylcholine hydroperoxides during copper oxidation of LDL and HDL by liquid chromatography/mass spectrometry.2012

    • Author(s)
      Hui SP, Taguchi Y, Takeda S, Ohkawa F, Sakurai T, Yamaki S, Jin S, Fuda H, Kurosawa T, Chiba H.
    • Journal Title

      Anal Bioanal Chem

      Volume: 403 Pages: 1831-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel monoclonal antibody recognizing triglyceride-rich oxidized LDLs associated with severe liver disease and small oxidized LDLs in normal subjects.2012

    • Author(s)
      Sakurai T, Ichikawa A, Furukawa H, Wada N, Nagasaka A, Takahashi Y, Fujikawa M, Ikuta A, Furumaki H, Shiga M, Shimizu C, Hui SP, Jin S, Takeda S, Fuda H, Nagasaka H, Kobayashi S, Chiba H.
    • Journal Title

      Ann ClinBiochem

      Volume: 49 Pages: 456-462

    • NAID

      120004979561

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oxidized LDL using a carbon nanotube electrode.2012

    • Author(s)
      Takeda S, Hui SP, Fukuda K, Fuda H, Jin s, Sakurai T, Ishii A, Mukasa K, Sueoka K, Chiba H.
    • Journal Title

      Sensor Actuator B Chem

      Volume: 167 Pages: 833-836

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phenolic antioxidant from the Pacific oyster (Crassostrea gigas) inhibits oxidation of cultured human hepatocytes mediated bydiphenyl-1-pyrenylphosphine.2012

    • Author(s)
      Watanabe M, Fuda H, Jin S, Sakurai T, Hui SP, Takeda S, Watanabe T, Koike T, Chiba H.
    • Journal Title

      FoodChemistry

      Volume: 134 Pages: 2086-2089

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection and characterization of cholesteryl ester hydroperoxides in oxidized LDL and oxidized HDL by use of an Orbitrap mass spectrometer2012

    • Author(s)
      Hui SP, et al
    • Journal Title

      Anal Bioanal Chem

      Volume: 404 Issue: 1 Pages: 101-112

    • DOI

      10.1007/s00216-012-6118-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel monoclonal antibody recognizing triglyceride-rich oxidized LDLs associated with severe liver disease and small oxidized LDLs in normal subjects2012

    • Author(s)
      Sakurai T
    • Journal Title

      Ann Clin Biochem

      Volume: (未定) Issue: 5 Pages: 456-462

    • DOI

      10.1258/acb.2012.011284

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phenolic antioxidant from the Pacific oyster (Crassostrea gigas) inhibits oxidation of cultured human hepatocytes mediated by diphenyl-1-pyrenylphosphine2012

    • Author(s)
      Watanabe M et al.
    • Journal Title

      Food Chem

      Volume: 134 Issue: 4 Pages: 2086-2089

    • DOI

      10.1016/j.foodchem.2012.04.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD36 deficiency predisposing young children to fasting hypoglycemia2012

    • Author(s)
      Watanabe M
    • Journal Title

      J Agric Food Chem

      Volume: 60 Pages: 830-835

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel monoclonal antibody recognizing triglyceride-rich oxidized LDLs associated with severe liver disease and small oxidized LDLs in normal subjects2012

    • Author(s)
      Sakurai T
    • Journal Title

      Ann Clin Biochem

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantnative determination of pnospnatidyicnoline hyaroperoxidesduring copper-oxidation of LDL and HDL by liquid chromatography/mass spectrometry2012

    • Author(s)
      Hui SP
    • Journal Title

      Anal Bioanal Chem

      Volume: (未定) Issue: 7 Pages: 1831-1840

    • DOI

      10.1007/s00216-012-5833-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 過酸化脂質およびブラズマローゲンに関する臨床化学的研究2012

    • Author(s)
      Hui SP
    • Journal Title

      臨床化学

      Volume: 41 Pages: 54-61

    • Related Report
      2011 Annual Research Report
  • [Journal Article] CD36 deficiency predisposing young children to fasting hypoglycemia.2011

    • Author(s)
      Nagasaka H, Yorifuji T, Takatani T, Okano Y, Tsukahara H, Yanai H, Hirano K, Hui SP, Hirayama S, Ito T, Chiba H, Miida T.
    • Journal Title

      Metabolism.

      Volume: Vol. 60 Pages: 881-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liquid chromatography mass spectrometric determination of plasmalogens in human plasma.2011

    • Author(s)
      Hui SP, Chiba H, Kurosawa T.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 400 Pages: 1923-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyses for phosphatidyl choline hydroperoxides by LC/MS.2010

    • Author(s)
      Hui SP, Chiba H, Jin S, Nagasaka H, Kurosawa T.
    • Journal Title

      JChromatogr B

      Volume: 878 Pages: 1677-82

    • NAID

      10028037840

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of lipoprotein particle sizes using dynamic light scattering.2010

    • Author(s)
      Sakurai T, Trirongjit- moah S, Nishibata Y, Namita T, Tsuji M, Hui SP, Jin S, Shimizu K, Chiba H.
    • Journal Title

      Ann Clin Biochem.

      Volume: 47 Pages: 476-81

    • NAID

      120002564656

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyses for phosphatidyl choline hydroperoxides by LC/MS2010

    • Author(s)
      Hui SP.
    • Journal Title

      J Chromatogr B.

      Volume: 878 Pages: 1677-1682

    • NAID

      10028037840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of the transport activities of bile salt export pump using chemiluminescence detection method2010

    • Author(s)
      Yamaguchi K.
    • Journal Title

      Yakugaku Zasshi

      Volume: 130 Pages: 755-761

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of Bile Salt Export Pump Transport Activities using a Fluorescent Bile Acid Derivative2010

    • Author(s)
      Yamaguchi K.
    • Journal Title

      Drug Metab.Pharmacokinet.

      Volume: 25 Pages: 214-219

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of lipoprotein particle sizes using dynamic light scattering2010

    • Author(s)
      Sakurai T.
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: 47 Pages: 476-481

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD36 deficiency predisposing young children to fasting hypoglycemia.2010

    • Author(s)
      Nagasaka H.
    • Journal Title

      Metabolism

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral separation, determination of absolute configuration, and high-performance liquid chromatography detection of enantiomeric 3-hydroxyhexadecanoyl-CoA2010

    • Author(s)
      Tsuchida S.
    • Journal Title

      J Oleo Sci.

      Volume: 60 Pages: 187-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liquid chromatography-mass spectrometric determination of plasmalogens in human plasma.2010

    • Author(s)
      Hui SP.
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 過酸化脂質測定の進歩2010

    • Author(s)
      恵淑萍
    • Journal Title

      臨床化学

      Volume: 39 Pages: 268-275

    • Related Report
      2010 Annual Research Report
  • [Presentation] CNT電極センサーによる抗酸化物質のLDL酸化抑制能測定法.2013

    • Author(s)
      大川芙多葉,武田晴治,惠淑萍,武笠幸一,櫻井俊宏,神繁樹,布田博敏,末岡和久,千葉仁志.
    • Organizer
      第80回日本電気化学会
    • Place of Presentation
      仙台(東北大学)
    • Year and Date
      2013-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] ケルビン測定を利用した低比重リポ蛋白質の酸化状態の評価.2013

    • Author(s)
      武田晴治,惠淑萍,武笠幸一,櫻井俊宏,神繁樹,布田博敏,末岡和久,千葉仁志.
    • Organizer
      第80回日本電気化学会
    • Place of Presentation
      仙台(東北大学)
    • Year and Date
      2013-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] マガキ由来の新規抗酸化物質における肝保護作用.2013

    • Author(s)
      布田博敏,渡邊貢,神繁樹,惠淑萍,武田晴治,櫻井俊宏,渡辺孝之,千葉仁志.
    • Organizer
      日本農芸化学会
    • Place of Presentation
      仙台(東北大学)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] リポタンパク質の金属酸化時のphosphatidyl choline hydroperoxides及びTBARSの経時変化.2012

    • Author(s)
      惠淑萍,櫻井俊宏,神繁樹,布田博敏,武田晴治,千葉仁志.
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 酸化低比重リポ蛋白質の検出におけるCNT電極の特異性2012

    • Author(s)
      武由晴治
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      アクトシティ浜松,(静岡)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC/MSによる酸化リポタンパク質におけるcholesterylester hydroperoxidesの分析2012

    • Author(s)
      惠淑萍
    • Organizer
      薬学会第132回年回
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] リポ蛋白い質の酸化における過酸化脂質とプラズマローゲンの濃度変化2012

    • Author(s)
      惠 淑萍
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      いわて県民情報交流センター (岩手県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative analyses of phosphatidylcholine hydroperoxides oxidized lipoprotein by LC/MS2012

    • Author(s)
      Hui SP et al
    • Organizer
      19th International Mass pectrometry Conference
    • Place of Presentation
      国立京都国際会館 (京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] LC-MS/MS による酸化リポタンパク質における過酸化リン脂質の定量分析2012

    • Author(s)
      惠 淑萍
    • Organizer
      第65回日本酸化ストレス学会学術集会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館 (徳島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] LC/MSによるヒト血中コリン型プラズマローゲンに関する分析2011

    • Author(s)
      山木志展
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食品由来の新規抗酸化物の同定2011

    • Author(s)
      布田博敏
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自製ELISAによる酸化リポ蛋白の測定とその有用性の検討2011

    • Author(s)
      櫻井俊宏
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC/MSによるLDL及びHDLにおける過酸化トリグリセリドの分析2011

    • Author(s)
      惠淑萍
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical implications of blood plasmalogens as a biomarker of atherosclerosis2011

    • Author(s)
      hara H
    • Organizer
      2011 International Society for Nutraceuticals and Functional Foods (ISNFF) Annual Conference Medicine and Engineering
    • Place of Presentation
      Royton Sapporo Hotel(札幌)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Isolation and characterization of a novel antioxidant from the pacific oyster (Crass ostrea gigas)2011

    • Author(s)
      fuda H
    • Organizer
      2011 International Society for Nutraceuticals and Functional Foods (ISNFF) Annual Conference Medicine and Engineering
    • Place of Presentation
      Royton Sapporo Hotel(札幌)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of various electrode materials for detection of oxidized lowdensity lipoprotein2011

    • Author(s)
      Takeda S
    • Organizer
      5th IEEE International Conference on Nano/Molecular Medicine and Engineering
    • Place of Presentation
      InternationalConventionCenterJeju (Korea)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] リポタンパク質の金属酸化におけるphosphatidyl choline hydroperoxidesの経時変化.2011

    • Author(s)
      田口裕大,惠淑萍,櫻井俊宏,黒澤隆夫,千葉仁志
    • Organizer
      第45回日本臨床検査医学会北海道支部総会
    • Place of Presentation
      旭川(旭川医科大学)
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] LDLandHDLにおけるコレステリルエステル過酸化脂質のLC/MSによる分析.2011

    • Author(s)
      惠淑萍,櫻井俊宏,古牧宏啓,黒澤隆夫,千葉仁志
    • Organizer
      第45回日本臨床検査医学会北海道支部総会
    • Place of Presentation
      旭川(旭川医科大学)
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] LC-MS/MSによる血中エタノールアミン型を含むプラズマローゲンの新規定量法の開発.2011

    • Author(s)
      山木志展,惠淑萍,神繁樹,黒澤隆夫,千葉仁志
    • Organizer
      第45回日本臨床検査医学会北海道支部総会
    • Place of Presentation
      旭川(旭川医科大学)
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] LC/MSによる血中エタノールアミン型を含むプラズマローゲンの新規定量法の開発2011

    • Author(s)
      山木志展
    • Organizer
      第45回日本臨床検査医学会北海道支部総会
    • Place of Presentation
      旭川医科大学(旭川)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] リポタンパク質の金属酸化におけるphosphatidyl choline hydroperoxidesの経時変化2011

    • Author(s)
      田口裕大
    • Organizer
      第45回日本臨床検査医学会北海道支部総会
    • Place of Presentation
      旭川医科大学(旭川)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] LDLとHDLにおけるコレステリルエステル過酸化脂質のLC/MSによる分析2011

    • Author(s)
      惠淑萍
    • Organizer
      第45回日本臨床検査医学会北海道支部総会
    • Place of Presentation
      旭川医科大学(旭川)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Plasmalogens in human lipoproteins : possible role for preventing oxidation-mediated lipoprotein modification clinical implications of blood plasmalogens as a biomarker of atherosclerosis2011

    • Author(s)
      Chiba H
    • Organizer
      2011 International Society for Nutraceuticals and Functional Foods (ISNFF) Annual Conference Medicine and Engineering
    • Place of Presentation
      Royton Sapporo Hotel(札幌)(招待講演)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitative analyses for PC hydroperoxides in plasma of healthy and liver failure by LC/MS2011

    • Author(s)
      Hui SP
    • Organizer
      17thInternational Biophysics Congress (IUPAB)
    • Place of Presentation
      中国国立会議中心(China)
    • Year and Date
      2011-10-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「健康を創る最先端技術と健康マネージメント」:「質量分析が可能にする分子レベルの健康科学」2011

    • Author(s)
      惠淑萍
    • Organizer
      北海道大学サステナビリテイ・ウイーク2011市民セミナー(シンポジウム)
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC-MSによるLDL及びHDLにおけるtriglyceride hydroperoxidesの分析2011

    • Author(s)
      惠淑萍
    • Organizer
      第36回日本医用マススペクトル学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC-MS/MSを用いた血清18-ヒドロキシコルチゾール定量法の開発2011

    • Author(s)
      神繁樹
    • Organizer
      第36回日本医用マススペクトル学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 原発性アルドステロン症鑑別診断における血清18-ヒドロキシコルチゾール定量の有用性の検討2011

    • Author(s)
      神繁樹
    • Organizer
      第36回日本医用マススペクトル学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 各種の過酸化脂質分子種及びプラズマローゲンのLC/MSによる定性定量分析2011

    • Author(s)
      惠淑萍
    • Organizer
      第36回日本医用マススペクトル学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2種類のHDL-C直接法を用いたapoE-containing HDL定量法2011

    • Author(s)
      高橋祐司
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 様々な修飾カーボンナノチューブ電極を利用した過酸化物質の測定2011

    • Author(s)
      武田晴治
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] カーボンナノチューブ電極を利用した酸化LDLの測定2011

    • Author(s)
      熊野綾子
    • Organizer
      第51向日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC/MS-MSによる血清中18-ヒドロキシコルチゾールの測定法の開発2011

    • Author(s)
      神繁樹
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 原発性アルドステロン症の鑑別診断における血清18-hydroxycortisolの有用性の検討2011

    • Author(s)
      和田典男
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC-MS/MSによる健常者血中phosphatidyl choline monohydroperoxidesの分析2011

    • Author(s)
      田口裕大
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 過酸化脂質及び抗酸化脂質に関する研究2011

    • Author(s)
      惠淑萍
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)(招待講演)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト血葉プラスマローゲンのリポ蛋白分布と金属酸化に対する反応性について2011

    • Author(s)
      千葉仁志
    • Organizer
      第1回プラスマローゲン研究会
    • Place of Presentation
      帝京大学(東京)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC-MS/MSによるヒト血中プラズマローゲンの新規測定法の開発2011

    • Author(s)
      山木志展
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxidized LDL and HDLにおけるコレステリルエステル過酸化脂質のLC/MSによる分析2011

    • Author(s)
      惠淑萍
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC/MSによる過酸化リン脂質及びプラズマローゲンに関する研究2011

    • Author(s)
      惠淑萍
    • Organizer
      質量分析計ユーザーズフォーラム2011
    • Place of Presentation
      東京コンファレンスセンター品川(東京)(招待講演)
    • Year and Date
      2011-07-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 金属酸化により得られた酸化LDLと酸化HDLにおける過酸化トリグリセリドのLC/MS定性分析2011

    • Author(s)
      惠淑萍
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(北海道)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規測定法による酸化リポ蛋白の解析2011

    • Author(s)
      櫻井俊宏
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(北海道)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] マガキ由来の新規抗酸化物質の抗酸化能2011

    • Author(s)
      布田博敏
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(北海道)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] apoCIIIとapoEの両者を持つリポ蛋白粒子(Lp-CIII-E)に関する研究2010

    • Author(s)
      古牧宏啓
    • Organizer
      第20回日本臨床化学会北海道支部例会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSの内部標準法によるプラズマローゲンの分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第20回日本臨床化学会北海道支部例会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] カーボンナノチューブ電極を用いた酸化LDLの測定2010

    • Author(s)
      武田晴治
    • Organizer
      第20回日本臨床化学会北海道支部例会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Improved LC/MS analytical method for PC hydroperoxides in human plasma2010

    • Author(s)
      Hui SP.
    • Organizer
      SFRBM's 17^<th> Annual Meeting (SFRBM : Society for Free Radical Biology and Medicine)
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSによるプラズマローゲンの分子種別リポ蛋白分布の解析2010

    • Author(s)
      生田知子
    • Organizer
      第44回臨床検査医学会北海道支部総会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSによる肝疾患患者血中の過酸化リン脂質の分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第44回臨床検査医学会北海道支部総会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 尿中18-hydroxycortisol高値により糖質コルチコイド奏功性アルドステロン症が示唆された症例2010

    • Author(s)
      神繁樹
    • Organizer
      第44回臨床検査医学会北海道支部総会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] カーボンナノチューブセンサーによる過酸化脂質・酸化LDLの測定2010

    • Author(s)
      武田晴治
    • Organizer
      第44回臨床検査医学会北海道支部総会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSによる健常人と肝不全患者血中過酸化リン脂質の分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] リポ蛋白中プラズマローゲンの分布に関する研究2010

    • Author(s)
      生田知子
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] プラズマローゲンの基質となる物質の化学合成2010

    • Author(s)
      山木志展
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] HDL-C直接法における界面活性剤種による反応性変化について2010

    • Author(s)
      高橋祐司
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化リポ蛋白の新規測定法の開発2010

    • Author(s)
      櫻井俊宏
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] apoCIIIとapoEの両者を持つリポタンパク粒子(Lp-CIII-E)の分布の検討2010

    • Author(s)
      古牧宏啓
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] カーボンナノチューブ電極を利用した過酸化脂質の測定2010

    • Author(s)
      武田晴治
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      県民文化ホール(山梨)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 過酸化脂質に関するLC/MS分析法2010

    • Author(s)
      恵淑萍
    • Organizer
      第1回北海道質量分析セミナー
    • Place of Presentation
      北海道大学(札幌) 招待講演
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSによるヒト血中過酸化リン脂質の分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化リポ蛋白自己抗体の研究:モノクローナル抗体の作製2010

    • Author(s)
      西端友香
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗apoE抗体と抗apoCIII抗体のsandwich-ELISAによるレムナントリポ蛋白の検出について2010

    • Author(s)
      古牧宏啓
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSによるプラズマローゲンのリポ蛋白分布の検討2010

    • Author(s)
      生田知子
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化リポ蛋白自己抗体の研究:臨床的検討2010

    • Author(s)
      櫻井俊宏
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC/MSによるプラズマローゲンの分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第35回日本医用マススペクトル学会年会
    • Place of Presentation
      (金城学院大学)名古屋
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝不全患者血中の抗酸化リポ蛋白自己抗体について2010

    • Author(s)
      櫻井俊宏
    • Organizer
      第6回東日本胆汁酸研究会
    • Place of Presentation
      経団連会館(東京)
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Qualitative analyses for PC hydroperoxides in human plasma by LC/MS2010

    • Author(s)
      Hui SP
    • Organizer
      American Association for Clinical Chemistry Annual Meeting 2010
    • Place of Presentation
      Anaheim, CA, USA.
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of Lipoprotein Particle Sizes Using Dynamic Light Scattering2010

    • Author(s)
      Sakurai T.
    • Organizer
      American Association for Clinical Chemistry Annual Meeting 2010
    • Place of Presentation
      Anaheim, CA, USA.
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two apoE-containing HDLs, lipid-rich and lipid-poor : Need to avoid confusion2010

    • Author(s)
      Takahashi Y.
    • Organizer
      American Association for Clinical Chemistry Annual Meeting 2010
    • Place of Presentation
      Anaheim, CA, USA.
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 疾患と酸化ストレス:過酸化脂質分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第23回バイオメデイカル分析科学シンポジウム
    • Place of Presentation
      ホテル松島大観荘(宮城県)
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-MS/MSによる健常者血中過酸化リン脂質の分析2010

    • Author(s)
      恵淑萍
    • Organizer
      第63回東日本酸化ストレス学会学術集会
    • Place of Presentation
      県民ホール(神奈川)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化リポ蛋白に対する自己抗体の新規測定法の開発2010

    • Author(s)
      櫻井俊宏
    • Organizer
      第63回東日本酸化ストレス学会学術集会
    • Place of Presentation
      県民ホール(神奈川)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC/MSを用いた血中過酸化リン脂質の分析2010

    • Author(s)
      恵淑萍
    • Organizer
      日本薬学会北海道支部第134回例会
    • Place of Presentation
      コンベンションセンター(札幌)
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] CNT センサーによる過酸化物を電気的に測定する方法2010

    • Inventor(s)
      千葉仁志、武田晴治、石井睦、中村基訓、武笠幸一、惠淑萍、黒澤隆夫
    • Industrial Property Rights Holder
      北海道大学、北海道医療大学
    • Filing Date
      2010-07-16
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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