| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Macrophages play a major role in the development of vascular lesions in atherogenesis. We had measured soluble FcуRIIIa^Mф derived from macrophages in plasma with anti-FcуRIIIa^Mф monoclonal antibodies and found patients with echogenic/echolucent plaques had the highest sFcуRIIIa^Mф levels, but patients with only calcificated plaques had levels similar to patients with no plaque or intact carotid artery. Because unstable plaques contain a lot of lipids and macrophages inside, the sFcуRIIIa^Mф may serve as a novel risk biomarker for unstable angina or myocardial infarction.
|
