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A novel marker for unstable plaques in atherosclerosis

Research Project

Project/Area Number 22590541
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKansai Medical University

Principal Investigator

MASUDA Midori  関西医科大学, 医学部, 講師 (50173753)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords動脈硬化 / FcуレセプターIIIa / CD16 / ELISA / 臨床検査 / マクロファージ / 可溶性FcγレセプターIIIa
Research Abstract

Macrophages play a major role in the development of vascular lesions in atherogenesis. We had measured soluble FcуRIIIa^Mф derived from macrophages in plasma with anti-FcуRIIIa^Mф monoclonal antibodies and found patients with echogenic/echolucent plaques had the highest sFcуRIIIa^Mф levels, but patients with only calcificated plaques had levels similar to patients with no plaque or intact carotid artery. Because unstable plaques contain a lot of lipids and macrophages inside, the sFcуRIIIa^Mф may serve as a novel risk biomarker for unstable angina or myocardial infarction.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (33 results)

All 2013 2012 2011 2010

All Journal Article (2 results) Presentation (31 results)

  • [Journal Article] NK細胞およびマクロファージの機能測定法.2011

    • Author(s)
      桝田緑,高橋伯夫.
    • Journal Title

      臨床病理

      Volume: 59(1) Pages: 50-54

    • NAID

      10029426809

    • Related Report
      2012 Final Research Report
  • [Journal Article] NK細胞およびマクロファージの機能測定法2011

    • Author(s)
      桝田緑。高橋伯夫
    • Journal Title

      臨床病理

      Volume: 59 Pages: 50-54

    • NAID

      10029426809

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Presentation] Soluble FcγRIIIaMφ levels in plasma correlate with stenosis rate in patients examined with carotid ultrasonography2013

    • Author(s)
      Midori MASUDA, Keiko KOUNO, Noriko NISHIMURA, Hiroya MASAKI, Toyohiko YOKOI, Yutaka KOMIYAMA, Toshiji IWASAKA, and Hakuo TAKAHASHI
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血圧脈波検査施行患者における可溶性FcγRIIIaMφの増加2013

    • Author(s)
      桝田緑,高橋伯夫
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increase of soluble FcγRIIIa derived from macrophages in plasma from patients examined with brachial-ankle pulse wave velocity.2012

    • Author(s)
      Midori MASUDA and Hakuo TAKAHASHI.
    • Organizer
      第41回日本免疫学会 総会・学術集会
    • Place of Presentation
      神戸、 神戸国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble FcуRIIIa^Mф levels in plasma correlate with maximum plaque diameter in patients examined with carotid arterial echography.2012

    • Author(s)
      Midori Masuda, Keiko Kouno, Noriko Nishimura, Hiroya Masaki, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi.
    • Organizer
      12th Asian Society of Clinical Pathology and Laboratory Medicine
    • Place of Presentation
      国立京都国際会館, Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 血圧脈波検査施行患者における可溶性FcуRIIIa^Mфの増加.2012

    • Author(s)
      桝田緑,横井豊彦,正木浩哉,高橋伯夫.
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2012 Final Research Report
  • [Presentation] 頸動脈エコー検査施行患者における可溶性FcуRIIIa^Mфの増加.2012

    • Author(s)
      桝田緑,高橋伯夫.
    • Organizer
      第40回日本臨床免疫学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of blood sugar on the value of soluble FcуRIIIa^Mф in plasma.2012

    • Author(s)
      Midori MASUDA and Hakuo TAKAHASHI
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡、ヒルトン福岡シーホーク
    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble FcgRIIIaMf levels in plasma correlate with maximum plaque diameter in patients examined with carotid arterial echography.2012

    • Author(s)
      Midori Masuda, Keiko Kouno, Noriko Nishimura, Hiroya Masaki, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi
    • Organizer
      12th Asian Society of Clinical Pathology and Laboratory Medicine
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of blood sugar on the value of soluble FcγRIIIaMφ in plasma2012

    • Author(s)
      Midori MASUDA and Hakuo TAKAHASHI
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡、ヒルトン福岡シーホーク
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頸動脈エコー検査施行患者における可溶性FcγRIIIaMφの増加2012

    • Author(s)
      桝田緑,高橋伯夫
    • Organizer
      第40回日本臨床免疫学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血圧脈波検査施行患者における可溶性FcγRIIIaMφの増加2012

    • Author(s)
      桝田緑,横井豊彦,正木浩哉,高橋伯夫
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increase of soluble FcγRIIIa derived from macrophages in plasma from patients examined with brachial-ankle pulse wave velocity.2012

    • Author(s)
      Midori MASUDA and Hakuo TAKAHASHI
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可溶性FcγRIIIs測定値に及ぼす血糖の影響.2011

    • Author(s)
      桝田緑,高橋伯夫.
    • Organizer
      第54回日本臨床検査医学会近畿支部総会
    • Place of Presentation
      大津、ピアザ淡海
    • Year and Date
      2011-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 可溶性FcγRIIIs測定値に及ぼす血糖の影響2011

    • Author(s)
      桝田緑, 高橋伯夫
    • Organizer
      第54回日本臨床検査医学会近畿支部総会
    • Place of Presentation
      大津、ピアザ淡海
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increase of soluble FcуRIIIa^Mф in plasma from patients examined with carotid artery echography2011

    • Author(s)
      Midori MASUDA and Hakuo TAKAHASHI.
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉、幕張メッセ
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎生検施行患者における尿中可溶性FcγRIIIsの増加.2011

    • Author(s)
      桝田緑,高橋伯夫.
    • Organizer
      第15回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Related Report
      2012 Final Research Report
  • [Presentation] 頸動脈エコー検査施行患者における可溶性FcγRIIIaMφの増加.2011

    • Author(s)
      桝田緑,高橋伯夫.
    • Organizer
      第15回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎症における尿中可溶性FcγRIIIaの増加.2011

    • Author(s)
      桝田緑,正木浩哉,高橋伯夫.
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山、岡山コンベンションセンター
    • Related Report
      2012 Final Research Report
  • [Presentation] Increase of soluble FcуRIIIa^Mф in plasma from patients examined with carotid artery echography.2011

    • Author(s)
      Midori MASUDA and Hakuo TAKAHASHI.
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌、ロイトン札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Increase of soluble FcγRIIIaMφ in plasma from patients examined with carotid artery echography2011

    • Author(s)
      Midori MASUDA, Hakuo TAKAHASHI
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌、ロイトン札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎症における尿中可溶性FcγRIIIaの増加2011

    • Author(s)
      桝田緑, 正木浩哉, 高橋伯夫
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      岡山,岡山コンベンションセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎生検施行患者における尿中可溶性FcγRIIIsの増加2011

    • Author(s)
      桝田緑, 高橋伯夫
    • Organizer
      第15回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] エコー検査施行患者における可容性FcγRIIIaMφの増加2011

    • Author(s)
      桝田緑, 高橋伯夫
    • Organizer
      第15回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪、千里ライフサイエンスセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increase of soluble FcγRIIIaMφ in plasma from patients examined with carotid artery echography2011

    • Author(s)
      Midori MASUDA, Hakuo TAKAHASHI
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉、幕張メッセ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血球細胞除去用浄化器アダカラム適用による可溶性FcγRIIIsの減少.2010

    • Author(s)
      桝田緑,高橋伯夫.
    • Organizer
      第53回日本臨床検査医学会近畿支部総会
    • Place of Presentation
      奈良、奈良文化会館
    • Related Report
      2012 Final Research Report
  • [Presentation] 頸動脈エコー検査施行患者における可溶性FcγRIIIaMφの増加.2010

    • Author(s)
      桝田緑,横井豊彦,正木浩哉,高橋伯夫.
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] NK細胞およびマクロファージの機能測定法.2010

    • Author(s)
      桝田緑,高橋伯夫.
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement of soluble FcуRIIIa and soluble FcуRIIIa^Mф in urine from patients with proteinuria.2010

    • Author(s)
      Midori Masuda, Satoshi Morimoto, Shi Yan Hong, Tatsuyoshi Morita, Noriko Nishimura, Nobuyuki Takahashi, Hiroya Masaki, Keiko Kouno, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸ポートピアホテル、 神戸国際展示場、Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement of soluble FcγRIIIa and soluble FcγRIIIa_<Mφ> in urine from patients with proteinuria.2010

    • Author(s)
      Midori Masuda, et, al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸ボートピアホテル、神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] NK細胞およびマクロファージの機能測定法2010

    • Author(s)
      桝田緑, 高橋伯夫
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王ブラザホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頸動脈エコー検査施行患者における可溶性FcγRIIIa_<Mφ>の増加2010

    • Author(s)
      桝田緑, 他
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王ブラザホテル
    • Related Report
      2010 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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