A novel marker for unstable plaques in atherosclerosis
| Project/Area Number |
22590541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
MASUDA Midori 関西医科大学, 医学部, 講師 (50173753)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動脈硬化 / FcуレセプターIIIa / CD16 / ELISA / 臨床検査 / マクロファージ / 可溶性FcγレセプターIIIa |
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| Research Abstract |
Macrophages play a major role in the development of vascular lesions in atherogenesis. We had measured soluble FcуRIIIa^Mф derived from macrophages in plasma with anti-FcуRIIIa^Mф monoclonal antibodies and found patients with echogenic/echolucent plaques had the highest sFcуRIIIa^Mф levels, but patients with only calcificated plaques had levels similar to patients with no plaque or intact carotid artery. Because unstable plaques contain a lot of lipids and macrophages inside, the sFcуRIIIa^Mф may serve as a novel risk biomarker for unstable angina or myocardial infarction.
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Report
(4 results)
Research Products
(33 results)
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[Presentation] Soluble FcуRIIIa^Mф levels in plasma correlate with maximum plaque diameter in patients examined with carotid arterial echography.2012
Author(s)
Midori Masuda, Keiko Kouno, Noriko Nishimura, Hiroya Masaki, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi.
Organizer
12th Asian Society of Clinical Pathology and Laboratory Medicine
Place of Presentation
国立京都国際会館, Kyoto, Japan
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[Presentation] Measurement of soluble FcуRIIIa and soluble FcуRIIIa^Mф in urine from patients with proteinuria.2010
Author(s)
Midori Masuda, Satoshi Morimoto, Shi Yan Hong, Tatsuyoshi Morita, Noriko Nishimura, Nobuyuki Takahashi, Hiroya Masaki, Keiko Kouno, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi.
Organizer
14th International Congress of Immunology
Place of Presentation
神戸ポートピアホテル、 神戸国際展示場、Kobe, Japan
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