Interaction of Host and Environmental factors for thelongitudinal change of atherosclerosis in Amami Longevity Area
| Project/Area Number |
22590551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kagoshima University |
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Principal Investigator |
NIIMURA Hideshi 鹿児島大学, 大学院・医歯学総合研究科, 講師 (80381177)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEZAKI Toshirou 鹿児島大学, 大学院・医歯学総合研究科, 教授 (50227013)
MIYATA Masaaki 鹿児島大学, 大学院・医歯学総合研究科, 講師 (00347113)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 分子遺伝学 / 動脈硬化 / 予防 / 環境・宿主相互作用 / 長寿 |
|---|
| Research Abstract |
After the use of CAVI values as a surrogate marker of arterial stiffness, CAVI values in Amami residents were significantly lower than those in Kagoshima mainland residents and healthy Japanese population. Geographical variation was not observed in the risk factors for atherosclerosis, and the geographical difference was associated with CAVI values after adjusted for those factors. The mean CAVI values in the CC genotype of CD14 C-260T polymorphism were significantly lower than those in the TT and CT genotypes. A significant positive association was observed between CAVI values and SNP in CD14 C-260T among men aged 34-49 years (coefficient=0.21, p=0.004). No significant association was observed between seven gene polymorphisms and five-years change in CAVI values.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees2012
Author(s)
Hirasada K, Niimura H, Kubozono T, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Matsushita T, Kusano K, Miyata M, Takezaki T
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Journal Title
J Atheroscler Thromb
Volume: 19
Pages: 69-80
NAID
Related Report
Peer Reviewed
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[Presentation] Association of polymorphisms in NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1 and TNF-α and environmental factors in the progression of atherosclerosis2013
Author(s)
Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Eva Mariane Mantjoro, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano, Toshiro Takezaki
Organizer
第23回日本疫学会学術総会
Place of Presentation
大阪
Year and Date
2013-01-25
Related Report
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[Presentation] Association of polymorphisms in NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1 and TNF-α and environmental factors in the progression of atherosclerosis.2013
Author(s)
Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Eva Mariane Mantjoro, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano, Toshiro Takezaki
Organizer
第23回日本疫学会学術総会
Place of Presentation
大阪
Related Report
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[Presentation] The prevalence of arterial stiffness and its related risk factors according to sex and age-group among general population in an island region of Japan2012
Author(s)
Kazuyo Kuwabara Hirasada, Hideshi Niimura, Takuro Kubozono, Akihiko Nakamura, Masaya Tatebo, Shin Ogawa, Noriko Nakahata, Motahare Kheradmand, Eva Mariane Mantjoro, Shirabe Ganjitsuda, Toshifumi Matsushita, Ken Kusano, Yasuhito Nerome, Tetsuhiro Owaki, Masaaki Miyata and Toshiro Takezaki
Organizer
19th Wonca Asia Pacific Regional Conference
Place of Presentation
Jeju Korea
Year and Date
2012-05-25
Related Report
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