Interaction of Host and Environmental factors for thelongitudinal change of atherosclerosis in Amami Longevity Area

• Project/Area Number: 22590551
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kagoshima University
• Principal Investigator: NIIMURA Hideshi 鹿児島大学, 大学院・医歯学総合研究科, 講師 (80381177)
• Co-Investigator(Kenkyū-buntansha): TAKEZAKI Toshirou 鹿児島大学, 大学院・医歯学総合研究科, 教授 (50227013) ; MIYATA Masaaki 鹿児島大学, 大学院・医歯学総合研究科, 講師 (00347113)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 分子遺伝学 / 動脈硬化 / 予防 / 環境・宿主相互作用 / 長寿

Research Abstract

After the use of CAVI values as a surrogate marker of arterial stiffness, CAVI values in Amami residents were significantly lower than those in Kagoshima mainland residents and healthy Japanese population. Geographical variation was not observed in the risk factors for atherosclerosis, and the geographical difference was associated with CAVI values after adjusted for those factors. The mean CAVI values in the CC genotype of CD14 C-260T polymorphism were significantly lower than those in the TT and CT genotypes. A significant positive association was observed between CAVI values and SNP in CD14 C-260T among men aged 34-49 years (coefficient=0.21, p=0.004). No significant association was observed between seven gene polymorphisms and five-years change in CAVI values.

Research Products

• [Journal Article] Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees (2012)
  • Author(s): Hirasada K, Niimura H, Kubozono T, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Matsushita T, Kusano K, Miyata M, Takezaki T
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 69-80
  • NAID: 130004721904
  • Peer Reviewed
• [Journal Article] Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees (2011)
  • Author(s): Kazuyo Hirasada
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Pages: 69-80
  • Peer Reviewed
• [Journal Article] Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors : A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. (2011)
  • Author(s): Wakai K
  • Journal Title: J.Epidemiol. Volume: (E Pub)
  • Peer Reviewed
• [Presentation] あまみ島嶼地域における動脈硬化とストレスに関する研究 (2013)
  • Author(s): 桑原和代、新村英士、中村昭彦、立棒雅也、小川信、中畑典子、Motahare Kheradmand、Mantjoro Eva Mariane、根路銘安仁、大脇哲洋、草野健、嶽崎俊郎
  • Organizer: 23回日本疫学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2013-01-26
• [Presentation] 日常身体活動量や運動習慣、海洋療法による動脈硬化要因及び医療費の改善に関する研究 (2013)
  • Author(s): 嶋谷圭一、桑原和代、新村英士、中村昭彦、立棒雅也、小川信、中畑典子、Motahare Kheradmand、Mantjoro Eva Mariane、根路銘安仁、大脇哲洋、草野健、嶽崎俊郎
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2013-01-25
• [Presentation] Association of polymorphisms in NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1 and TNF-α and environmental factors in the progression of atherosclerosis (2013)
  • Author(s): Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Eva Mariane Mantjoro, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano, Toshiro Takezaki
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2013-01-25
• [Presentation] あまみ島嶼地域における動脈硬化とストレスに関する研究 (2013)
  • Author(s): 桑原和代，新村英士，中村昭彦，立棒雅也，小川信，中畑典子，Motahare Kheradmand，Mantjoro Eva Mariane，根路銘安仁，大脇哲洋，草野健，嶽崎俊郎
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] Association of polymorphisms in NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1 and TNF-α and environmental factors in the progression of atherosclerosis. (2013)
  • Author(s): Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Eva Mariane Mantjoro, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano, Toshiro Takezaki
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] The prevalence of arterial stiffness and its related risk factors according to sex and age-group among general population in an island region of Japan (2012)
  • Author(s): Kazuyo Kuwabara Hirasada, Hideshi Niimura, Takuro Kubozono, Akihiko Nakamura, Masaya Tatebo, Shin Ogawa, Noriko Nakahata, Motahare Kheradmand, Eva Mariane Mantjoro, Shirabe Ganjitsuda, Toshifumi Matsushita, Ken Kusano, Yasuhito Nerome, Tetsuhiro Owaki, Masaaki Miyata and Toshiro Takezaki
  • Organizer: 19th Wonca Asia Pacific Regional Conference
  • Place of Presentation: Jeju Korea
  • Year and Date: 2012-05-25
• [Presentation] The change of CAVI values during 5 years among general population of islands of Kagoshima (2012)
  • Author(s): Motahare Kheradmand、新村英士、平佐田和代、中畑典子、中村昭彦、Mantjoro Eva Mariane、根路銘安仁、大脇哲洋、草野健、嶽崎俊郎
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-27
• [Presentation] 眼底所見(Scheie分類)を用いたCardio Ankle Vascular Index (CAVI) の妥当性に関する研究 (2012)
  • Author(s): 新村英士、平佐田和代、中畑典子、中村昭彦、Motahare Kheradmand、Mantjoro Eva、鈴木賢二、嶽崎俊郎
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-27
• [Presentation] 眼底所見(Scheie分類)を用いたCardio Ankle Vascular Index (CAVI)の妥当性に関する研究 (2012)
  • Author(s): 新村英士
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京(学術総合センター・一橋記念講堂)
  • Year and Date: 2012-01-27
• [Presentation] The change of CAVI values during 5 years among general population of islands of Kagoshima (2012)
  • Author(s): Motahare Kheradmand
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京(学術総合センター・一橋記念講堂)
  • Year and Date: 2012-01-27
• [Presentation] The change of CAVI values during 5 years among general population of islands of Kagoshima (2011)
  • Author(s): Motahare Kheradmand, Hideshi Niimura, Kazuyo Hirasada, Noriko Nakahata, Akihiko Nakamura, Eva Mariane Mantjoro, Yasuhito Nerome, Tetsuhiro Owaki, Ken Kusano, Toshiro Takezaki
  • Organizer: 第8回 血管バイオメカニクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] あまみ島嶼地域における健診受診者の健康意識に関する研究 (2011)
  • Author(s): 平佐田和代、中畑(常松)典子、中村昭彦、Motahareh Kheradmand Sarokalaei、Eva Mariane Mantjoro、新村英士、嶽崎俊郎
  • Organizer: 第21回九州農村医学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-06-04
• [Presentation] あまみ島嶼地域における動脈硬化に関する横断的研究 (2011)
  • Author(s): 平佐田和代
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: かでる2.7(札幌)
  • Year and Date: 2011-01-22
• [Presentation] 血中HDLコレステロール濃度に関わる遺伝子多型及び生活習慣に関する横断研究 (2011)
  • Author(s): 中村昭彦
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: かでる2.7(札幌)
  • Year and Date: 2011-01-22
• [Presentation] J-MICC Study Group, 血中HDLコレステロール濃度に関わる遺伝子多型及び生活習慣に関する横断研究 (2011)
  • Author(s): 中村昭彦、新村英士、嶽崎俊郎、久保充明、田中英夫、若井建志、浜島信之
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道
  • Year and Date: 2011-01-21
• [Presentation] あまみ島嶼地域における動脈硬化に関する横断的研究 (2011)
  • Author(s): 平佐田和代、新村英士、窪薗琢郎、中村昭彦、立棒雅也、小川信、常松典子、千葉調、松下俊文、草野健、宮田昌明、嶽崎俊郎
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道
  • Year and Date: 2011-01-21
• [Presentation] 離島地域での罹患調査におけるレセプトを用いた郵送調査と医療機関調査の感度に関する研究 (2011)
  • Author(s): 新村英士、平佐田和代、中村昭彦、常松典子、小川信、千葉調、根路銘安仁、大脇哲洋、嶽崎俊郎
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道
  • Year and Date: 2011-01-21
• [Presentation] 離島地域での罹患調査におけるレセプトを用いた郵送調査と医療機関調査の感度に関する研究 (2011)
  • Author(s): 新村英士
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: かでる2.7(札幌)
  • Year and Date: 2011-01-21
• [Presentation] あまみ島嶼地域と鹿児島県本土における動脈硬化の分布に関する比較疫学研究 -第2報 (2010)
  • Author(s): 平佐田和代、新村英士、窪薗琢郎、立棒雅也、小川信、常松典子、中村昭彦、千葉調、宮田昌明、草野健、松下俊文、嶽崎俊郎
  • Organizer: 第7回 血管バイオメカニクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-06
• [Book] The Islands of Kagoshima Culture, Society Industry and Nature (2013)
  • Author(s): Kei Kawai, Ryuta Terada and Sueo Kuwahara
  • Total Pages: 158
  • Publisher: Kagoshima University Research Center for the Pacific Islands
• [Remarks]
  • URL: http://www.kufm.kagoshima-u.ac.jp/~islands/