| Project/Area Number |
22590567
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Seinan Jo Gakuin University |
|---|
Principal Investigator |
KAI Tatsuo 西南女学院大学, 保健福祉学部栄養学科, 教授 (60331899)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ONOUE Hitoshi 西南女学院大学, 保健福祉学部・栄養学科, 教授 (70221166)
MIZUMA Tomochika 西南女学院大学, 保健福祉学部・栄養学科, 準教授 (40555504)
TASHIRO Yukihiro 西南女学院大学短期大学部, 準教授 (90448481)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Yasushi 鹿児島大学, 大学院・先端応用生命科学, 教授 (10100736)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 食品衛生 / 抗カビ性成分 / 乳酸菌 / パネットーネ / 抗カビ剤 / 食品添加物 / パネットーネ乳酸菌 / 抗菌剤 / DNA合成阻害活性 / 化学構造解析 |
|---|
| Research Abstract |
DNA synthesis was inhibited by the anti-mold factor excreted by panettone lactobacilli. As the result of LCMS differential analysis between high activity fraction and low activity fraction, the molecular weight and the chemical composition of the possible targeted factor was successfully obtained. Considering that this factor is inhibitory to the growth of both the gram negative- and positive-bacteria and mold, and also considering its action point of inhibiting the growth of bacteria and its molecular weight, it is expected that this factor might be a novel type antibiotic of new-quinolon.
|
