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Industrial cohort study of lifestyle related and cancer diseases among shift workers

Research Project

Project/Area Number 22590618
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

KUBO Tatsuhiko  産業医科大学, 医学部, 講師 (00446121)

Co-Investigator(Kenkyū-buntansha) FUJINO Yoshihisa  産業医科大学, 医学部, 准教授 (80352326)
MURAMATSU Keiji  産業医科大学, 医学部, 助教 (00644022)
MATSUDA Shinya  産業医科大学, 医学部, 教授 (50181730)
HAYASHIDA Kenshi  産業医科大学病院, 部長 (80363050)
Research Collaborator OYAMA Ichiro  産業医科大学, 医学部, 非常勤助教
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords産業医学 / 時間生物学 / 交替制勤務 / 生活習慣病 / 前立腺がん / 体内時計 / 健康保険組合 / レセプト / 職域がん検診 / 肥満 / 糖尿病
Outline of Final Research Achievements

We have conducted series of epidemiological studies to evaluate health risk among shift workers using certain company data. The data included periodic health checkups results and medical claim data of the health insurance society of the company. The studies accomplished 13 papers (of those, seven papers were with peer-review process) and 28 times conference presentation (of those, 11 were invited presentation). The studies succeed to obtain new evidence such as; the risk of hypertension was still observed among shift workers free form obesity; impact of shift schedules on health varies by outcome measures and there might be no “ultimate shift schedule” which secures all health outcomes. Also for prostate cancer risk, additional prospective follow up of the workers contribute to obtain result with higher statistical likelihood compared to retrospective dataset analysis.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (47 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Invited: 14 results) Book (2 results)

  • [Journal Article] 労働環境とサーカディアンリズム-交替制勤務による健康影響について2015

    • Author(s)
      久保達彦
    • Journal Title

      医学の歩み

      Volume: 253 Pages: 225-228

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 我が国の深夜交替制勤務労働者数の推計2014

    • Author(s)
      久保達彦
    • Journal Title

      産業医科大学雑誌

      Volume: 36 Pages: 273-276

    • NAID

      110009878658

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Industry-based Cohort Study of the Association between Weight Gain and Hypertension Risk among Rotating Shift Workers2013

    • Author(s)
      Kubo T, Fujino Y, Nakamura T, Kunimoto M, Tabata H, Tsuchiya T, Kadowaki K, Odoi H, Oyama I, Matsuda S
    • Journal Title

      Journal of occupational and environmental medicine

      Volume: 55(9) Issue: 9 Pages: 1041-1045

    • DOI

      10.1097/jom.0b013e31829731fd

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 交替制勤務者の発がんリスク評価に関する時間生物学の進展2013

    • Author(s)
      久保達彦
    • Journal Title

      時間生物学

      Volume: 19(1) Pages: 11-16

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 深夜業の定義に関する国際比較2013

    • Author(s)
      久保達彦 村松圭司 藤野善久 林田賢史 松田晋哉
    • Journal Title

      産業医科大学雑誌

      Volume: 35 Pages: 163-168

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 交代制勤務者の生活習慣病及び悪性腫瘍リスク2013

    • Author(s)
      久保達彦
    • Journal Title

      日本臨床

      Volume: 71(12) Pages: 2206-2212

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 避けられない不規則生活とアンチエイジング2013

    • Author(s)
      久保達彦
    • Journal Title

      日本抗加齢医学会雑誌

      Volume: 9(2) Pages: 199-203

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective cohort study of the risk of impaired glucose tolerance among shift workers2012

    • Author(s)
      Ichiro Oyama
    • Journal Title

      Scandinavian Journal of Work, Environment & Health

      Volume: 38 Issue: 4 Pages: 337-342

    • DOI

      10.5271/sjweh.3297

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective Cohort Study of the Risk of Impaired Glucose Tolerance among Shift Workers2012

    • Author(s)
      Ichiro Oyama, et al
    • Journal Title

      Scandinavian Journal of Work, Environment & Health

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective cohort study of the risk of obesity among shift workers : findings from the Industry-based Shift Workers' Health study, Japan2011

    • Author(s)
      Tatsuhiko Kubo, et al
    • Journal Title

      Occupational and Environmental Medicine

      Volume: 68 Issue: 5 Pages: 327-331

    • DOI

      10.1136/oem.2009.054445

    • NAID

      110009593211

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Industry based retrospective cohort study of the risk of prostate cancer among rotating shift workers.2011

    • Author(s)
      Tatsuhiko Kubo, et al.
    • Journal Title

      International Journal of Urology

      Volume: 18 Pages: 206-211

    • NAID

      10030822105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 交替制勤務者の悪性腫瘍リスク~前立腺がん・乳がんリスクを中心に~2010

    • Author(s)
      久保達彦
    • Journal Title

      労働の科学

      Volume: 65 Pages: 4-8

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Retrospective cohort study of the risk of obesity among shift workers : findings from the Industry based Shift Workers'Health study, Japan

    • Author(s)
      Tatsuhiko Kubo, et al.
    • Journal Title

      Occupational and Environmental Medicine

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Night shift work and risk of cancer; Key information of the issue for practice2015

    • Author(s)
      Tatsuhiko Kubo
    • Organizer
      31st International Congress on Occupational Health, Mini-symposium. Challenges and strategies for shift and long work.
    • Place of Presentation
      COEX, World Trade Center, Seoul (Korea)
    • Year and Date
      2015-06-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 交代制勤務による健康影響 疫学の立場から2015

    • Author(s)
      久保達彦
    • Organizer
      産業睡眠医学フォーラム
    • Place of Presentation
      産業医科大学(福岡県・北九州市)
    • Year and Date
      2015-03-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 交代制勤務者の健康管理の発展方向性―発がんリスクを踏まえて2014

    • Author(s)
      久保達彦
    • Organizer
      産業保健人間工学第19回大会 シンポジウム2 産業保健と睡眠
    • Place of Presentation
      北九州市立大学(福岡県・北九州市)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Risk of Hypertension and Impaired Glucose Tolerance among Two and Three Shift Workers2014

    • Author(s)
      Tatsuhiko Kubo, Yoshihisa Fujino, Takehiro Nakamura, Masamizu Kunimoto, Koji Kadowaki, Hidetoshi Tabata, Takuto Tsuchiya, Haruka Odoi, Ichiro Oyama, Shinya Matsuda
    • Organizer
      20th World Congress of Epidemiology, in Anchorage
    • Place of Presentation
      Dena’ina Civic and Convention Center, Anchorage (United States of America)
    • Year and Date
      2014-08-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 避けられない勤労者不規則生活 - 抗加齢医学の視点から交替制勤務者健康リスクに学ぶこと2014

    • Author(s)
      久保達彦
    • Organizer
      第87回日本作業衛生学会 メインシンポジウム1  抗加齢・健康長寿に向けた産業医学の新展開
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 交替制勤務者の発がんリスク―最新動向とその論点2014

    • Author(s)
      久保達彦
    • Organizer
      21世紀産業医学研究会
    • Place of Presentation
      厚生労働省
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 交代制勤務に伴う乳がんリスクの論点―看護労働現場における現実的対応2013

    • Author(s)
      久保達彦
    • Organizer
      第35回日本睡眠学会定期学術集会シンポジウム 「交代勤務に従事する看護師の睡眠問題 -現場のニーズと研究とのギャップ―」
    • Place of Presentation
      秋田キャッスルホテル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 避けられない不規則生活とアンチエイジング―交代制勤務による健康影響に学ぶこと2013

    • Author(s)
      久保達彦
    • Organizer
      第13回日本抗加齢医学会総会シンポジウム 生活の基盤となる体内時計機構~分子から生体まで~
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 時計遺伝子とメタボリズム―働く人々の健康管理の視点から2013

    • Author(s)
      久保達彦
    • Organizer
      第13回抗加齢医学の実際2013
    • Place of Presentation
      品川グランドセントラルタワー
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生物時計とがんリスクなどの疫学調査―産業疫学研究の取り組み事例から2013

    • Author(s)
      久保達彦
    • Organizer
      第20回日本時間生物学会学術大会シンポジウム 生物時計を基盤にした基礎・臨床橋渡し研究
    • Place of Presentation
      近畿大学東大阪キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] From the Viewpoint of Occupational Medicine-Cancer Risk due to Shift Work2012

    • Author(s)
      久保達彦
    • Organizer
      第89回日本生理学会大会シンポジウム体内時計の生理学的意味を他の研究分野から問う
    • Place of Presentation
      信州大学松本キャンパス(長野県松本市)(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Retrospective Cohort Study of the Risk of Hypertension among Shift Workers2012

    • Author(s)
      Tatsuhiko Kubo, et al
    • Organizer
      30th International Congress on Occupational Health
    • Place of Presentation
      Cancun Center, Cancun, Mexico(Oral presentation)
    • Year and Date
      2012-03-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 交替勤務者の疾病リスク評価の方向性2012

    • Author(s)
      久保達彦
    • Organizer
      第1回九州山口リズム研究会
    • Place of Presentation
      九大箱崎キャンパス(福岡市東区)(招待講演)
    • Year and Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 交代制勤務者の高血圧症リスクに関する後ろ向きコホート研究2012

    • Author(s)
      久保達彦, ら
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      学術総合センター・一橋記念講堂(東京都千代田区)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 交替勤務者の悪性腫瘍の疫学エビデンスと研究・実務的対応の方向性2011

    • Author(s)
      久保達彦
    • Organizer
      第18回日本時間生物学会学術大会シンポジウム:生活リズムと健康の疫学
    • Place of Presentation
      名古屋大学(愛知県名古屋市)(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cancer Risk among Shift Workers-Future Perspective of the Risk Assessments2011

    • Author(s)
      Tatsuhiko Kubo, et al
    • Organizer
      XII Congress of the European Biological Rhythms Society
    • Place of Presentation
      University of Oxford, Oxford, United Kingdom
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prospective Cohort Study of Preexisting Sleep Disorders and Subjective Adaptation to Shift Work2011

    • Author(s)
      Tatsuhiko Kubo, et al
    • Organizer
      20th International Symposium on Shiftwork and Working Time
    • Place of Presentation
      Radisson Blu Royal Park Hotel, Stockholm, Sweden
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Retrospective Cohort Study of the Risk of Impaired Glucose Tolerance among Shift Workers : Findings from the Industry-based Shift Workers' Health Study, Japan2011

    • Author(s)
      Tatsuhiko Kubo, et al
    • Organizer
      20th International Symposium on Shiftwork and Working Time
    • Place of Presentation
      Radisson Blu Royal Park Hotel, Stockholm, Sweden(Oral presentation)
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 交代制勤務(概日周期の乱れ)による悪性腫瘍リスクに関するレビュー2011

    • Author(s)
      久保達彦, ら
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      ニューピアホール(東京都港区)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 職域における前立腺ガンPSA検診の実態調査:事前説明と陽性通知に伴うQOL障害の関連2010

    • Author(s)
      久保達彦, ら
    • Organizer
      第69回日本公衆衛生学会総会
    • Place of Presentation
      東京国際フォーラム(千代田区)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 職域における前立腺ガンPSA検診の実態調査2010

    • Author(s)
      久保達彦, ら
    • Organizer
      第28回産業医科大学学会総会
    • Place of Presentation
      産業医科大学(北九州市)
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 交替制勤務による健康影響2010

    • Author(s)
      久保達彦
    • Organizer
      時間学特別セミナー
    • Place of Presentation
      山口大学(宇部市)
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Circadian Disruption due to Shift Work and Risk of Prostate Cancer概日周期の乱れと前立腺がん-交替制勤務者の悪性腫瘍リスク2010

    • Author(s)
      久保達彦, ら
    • Organizer
      第3回前立腺生物学シンポジウム
    • Place of Presentation
      鳥羽国際ホテル(鳥羽市)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 職域における前立腺ガンPSA検診の実態調査:インフォームドコンセントの実状とQOL障害、そしてPSA検診への期待2010

    • Author(s)
      久保達彦, ら
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      岩手県民情報交流センター(盛岡市)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 交替制勤務従事看護師の悪性腫瘍リスクに関する議論の要点

    • Author(s)
      久保達彦
    • Organizer
      第85回日本産業衛生学会市民公開シンポジウム「看護師が健康に働き続けるための職場の課題と対策」
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 交替制勤務スケジュールが高血圧リスクに与える影響に関する大規模コホート研究

    • Author(s)
      久保達彦
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(北海道札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 交替制勤務者の発がんリスク-時間生物学への扉

    • Author(s)
      久保達彦
    • Organizer
      第10回日本時間生物学会学術奨励賞受賞講演
    • Place of Presentation
      北海道大学学術交流会館(北海道札幌市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Retrospective cohort study of the risk of obesity among shift workers: findings from the Industry-based Shift Workers‘ Health study, Japan

    • Author(s)
      久保達彦
    • Organizer
      第30回産業医科大学学会・第24回産業医学推進研究会全国大会(合同開催)学会長賞受賞講演
    • Place of Presentation
      産業医科大学ラマティーニホール(福岡県北九州市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 交替制勤務スケジュールが高血圧症および耐糖能異常症リスクに与える影響

    • Author(s)
      久保達彦
    • Organizer
      第23回日本疫学会学術総会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪府吹田市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 交替制勤務による健康影響の社会制御

    • Author(s)
      久保達彦
    • Organizer
      第2回九州山口リズム研究会
    • Place of Presentation
      琉球大学理学部(沖縄県中頭群)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 交代制勤務に伴う乳がんリスクの論点-看護労働現場における現実的対応

    • Author(s)
      久保達彦
    • Organizer
      第35回日本睡眠学会定期学術集会
    • Place of Presentation
      秋田キャッスルホテル(秋田県秋田市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 避けられない不規則生活とアンチエイジング-交代制勤務による健康影響に学ぶこと

    • Author(s)
      久保達彦
    • Organizer
      第13回日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 睡眠マネジメント―産業衛生・疾病との係わりから最新改善対策まで2014

    • Author(s)
      久保達彦, 高橋 正也, 白川修一郎
    • Total Pages
      328
    • Publisher
      エヌティーエス
    • Related Report
      2014 Annual Research Report
  • [Book] 体内時計の科学と産業応用原稿第26章交替制勤務による発がんリスク(P218-225)2011

    • Author(s)
      久保達彦
    • Total Pages
      252
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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