| Project/Area Number |
22590649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
SHIMADA Yutaka 富山大学, 大学院・医学薬学研究部(医学), 教授 (80251891)
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| Co-Investigator(Renkei-kenkyūsha) |
HIKIAMI Hiroaki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (70345586)
FUJIMOTO Makoto 富山大学, 附属病院, 講師 (30377337)
GOTO Hirozo 富山大学, 大学院・医学薬学研究部(医学), 准教授 (40313598)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 東洋医学 / 和漢薬 / 漢方 / メタボリックシンドローム / 血管内皮機能 / 動脈硬化 |
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| Research Abstract |
We clarified the improvement effect of keishibukuryogan, a traditional Japanese （Kampo) formula, on endothelial function in patients with metabolic syndrome-related factors by controlled clinical trial with cross-over design. In 49 patients who completed all the tests, the index for the evaluation of endothelial function （L_RHI) assessed by Endo-PAT2000 increased significantly, and the serum non-esterified fatty acid （NEFA), malondialdehyde （MDA) and soluble vascular cell adhesion molecule-1（sVCAM-1) decreased significantly after 4 weeks of KBG-treatment period, and the changes of L_RHI, NEFA and MDA in the treatment period were significantly different from those in the control period
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