New therapeutic strategy against age-related vascular injury targetedto L-type amino acid transporter

• Project/Area Number: 22590665
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kyorin University
• Principal Investigator: KOZAKI Koichi 杏林大学, 医学部, 教授 (80272540)
• Co-Investigator(Renkei-kenkyūsha): NAGAI Kumiko 杏林大学, 医学部, 実験助手 (60398592)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 老年医学 / 血管傷害 / LAT1 / 新生内膜肥厚 / ダブル欠損マウス / 血液脳関門 / 細胞周期 / 頸動脈 / 内膜肥厚

Research Abstract

A series of in vivo and in vitro experiments have revealed that L-type amino acid transporter 1 (LAT1) is pivotal for the growth of cultured vascular smooth muscle cells, and the growth of intimal thickening in the injured artery. And, therapeutic experiments targeted to LAT1 in the vascular smooth muscle cells inhibited intimal growth of the artery. These results indicate a new therapeutic LAT1-targeted strategy against age-related vascular injury.

Research Products

• [Journal Article] Relationship between interleukin-6 and cerebral deep white matter and periventricular hyperintensity in elderly women (2011)
  • Author(s): Nagai K, Kozaki K, SonoharaK, Akishita M, Toba K
  • Journal Title: Geriatr Gerontol Int Volume: 11(in press)
  • NAID: 10031147972
  • Peer Reviewed
• [Journal Article] 認知症の周辺症状と介護負担感に対する抑肝散長期投与の効果 (2010)
  • Author(s): 町田綾子、山田如子、木村紗矢香、神崎恒一、鳥羽研二
  • Journal Title: 日本老年医学会雑誌 Volume: 47(3) Pages: 262-263
  • NAID: 10026895508
  • Peer Reviewed
• [Journal Article] Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment (2010)
  • Author(s): Yamada S, Akishita M, Fukai S, Ogawa S, Yamaguchi K, Matsuyama J, Kozaki K, Toba K, Ouchi Y
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 280-287
  • NAID: 10027755257
  • Peer Reviewed
• [Presentation] L-type amino acid transporter 1-mediated smooth muscle proliferation and viability, and evidence of its role in neointima formation (2012)
  • Author(s): Kumiko Nagai, Hitomi Koshiba, Shigeki Shibata, Koichi Kozaki
  • Organizer: 第20回日本血管生物医学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2012-12-06
• [Presentation] L-type amino acid transporter 1-mediated smooth muscle proliferation and viability, and evidence of its role in neointima formation. (2012)
  • Author(s): Kumiko Nagai, Koichi Kozaki
  • Organizer: 日本血管生物医学会総会
  • Place of Presentation: あわぎんホール(徳島県)
• [Presentation] L-type amino acid transporter 1-mediated smooth muscle proliferation and viability, and evidence of its role in neointima formation. (2010)
  • Author(s): Koichi Kozaki, Kumiko Nagai, Hang Xi, Kenji Toba
  • Organizer: 第42回日本動脈硬化学会総会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] L-type amino acid transporter 1-mediated smooth muscle proliferation and viability, and evidence of its role in neointima formation (2010)
  • Author(s): Kozaki K, Nagai K, Hang X, Toba K
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2010-07-16
• [Presentation] 軽度認知機能障害における脳委縮・脳血流と動脈硬化との関連 (2010)
  • Author(s): 永井久美子、神崎恒一、小林義雄、鳥羽研二
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-06-24
• [Presentation] 臨床治療薬の生存寿命への影響 パラコート障害モデルを用いたARBによる生存寿命延長効果の検討 (2010)
  • Author(s): 望月諭、小川純人、秋下雅弘、大田秀隆、石井正紀、飯島勝矢、江頭正人、神崎恒一、鳥羽研二、大内尉義
  • Organizer: 第47回日本臨床分子医学会
  • Place of Presentation: 有楽町朝日ホール、東京圏際フォーラム(東京都)
  • Year and Date: 2010-04-11