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Effect of acupuncture on the molecular mechanism of inflammation via transcription factor, NFkB.

Research Project

Project/Area Number 22590670
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionMorinomiya University of Medical Sciences

Principal Investigator

MATSUKUMA Hideaki  森ノ宮医療大学, 保健医療学部, 講師 (70518638)

Co-Investigator(Kenkyū-buntansha) AOKI Motokuni  森ノ宮医療大学, 保健医療学部, 教授 (00346214)
KAWAHATA Hirohisa  森ノ宮医療大学, 保健医療学部, 助教 (30454680)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords東洋医療 / 鍼灸刺激 / 炎症性腸疾患 / 筋肉再生 / 創傷治癒 / 炎症性サイトカイン / マクロファージ / 内科学一般 / 東洋医学 / 炎症 / 転写因子 / NFkB / サイトカイン
Research Abstract

Recently, there has been a focus on a variety of complementary and alternative medicine in the field of health care. However, the effect of acupuncture is still unclear. In this study we investigated the effect of acupuncture and moxibustion on molecular mechanisms of inflammation. Procedure of acupuncture into normal skin resulted in no effect on local inflammation. However, our data demonstrated that electro-acupuncture supressed disease activity and colonic inflammation in DSS-induced colitis through a reduction in propagated colonic peristalsis mediated by sympathetic over-activity, suggesting the potential of acupuncture as a relief therapy for inflammatory bowel disease. On the other hand, moxibustion accelerated muscle regeneration and promoted wound healing through induction of inflammation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Anti-inflammatory effect of electro-acupuncture via rduction in clonic pristalsis in a mouse model of inflammatory bowel disease.2013

    • Author(s)
      Yutani T, Kawahata H, Sotobayashi D, Kawanami H, Matsukuma H, Aoki M.
    • Journal Title

      Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry.

      Volume: 13(2) Issue: 2 Pages: 122-131

    • DOI

      10.2174/1871522211313020006

    • Related Report
      2012 Final Research Report
  • [Journal Article] Anti-inflammatory Effect of Electro-acupuncture via Reduction in Colonic Peristalsis in a Mouse Model of Inflammatory Bowel Disease.2013

    • Author(s)
      Yutani T
    • Journal Title

      Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

      Volume: 13(2) Pages: 112-121

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 灸刺激が創傷治癒過程に与える影響2013

    • Author(s)
      川波博、湯谷達、川畑浩久、青木元邦
    • Organizer
      全日本鍼灸学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2013-06-09
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 腸炎モデルマウスに対する鍼刺激の影響-炎症性腸疾患への補完医療確立に向けて-2013

    • Author(s)
      湯谷達、川畑浩久、青木元邦
    • Organizer
      全日本鍼灸学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2013-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 腸炎モデルマウスに対する鍼刺激の影響-炎症性腸疾患への補完医療確立に向けて-2013

    • Author(s)
      青木元邦
    • Organizer
      全日本鍼灸学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腸炎モデルマウスに対する鍼刺激の影響-炎症性腸疾患への補完医療確立に向けて-2012

    • Author(s)
      湯谷達、浅野真里絵、川畑浩久、青木元邦
    • Organizer
      全日本鍼灸学会学術大会
    • Place of Presentation
      三重
    • Year and Date
      2012-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 腸炎モデルマウスに対する鍼刺激の影響-炎症性腸疾患への補完医療確立に向けて-2012

    • Author(s)
      青木元邦
    • Organizer
      全日本鍼灸学会学術大会
    • Place of Presentation
      三重
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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