Pharmacological study of royal jelly, anti-aging element

• Project/Area Number: 22590673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Sojo University
• Principal Investigator: YOKOMIZO Kazumi 崇城大学, 薬学部, 教授 (80240919)
• Co-Investigator(Kenkyū-buntansha): MIYATA Takeshi 崇城大学, 薬学部, 客員研究員 (90040310)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 東洋医学 / 健康食品 / ローヤルゼリー / アンチ・エイジング

Research Abstract

Curing disease-oriented state, very early stage of diseases before they appear, by health suppliments is important to preserve health and prevent illness. In this study, we found that royal jelly has estrogenic and glucocorticoid-like activities. We also found that the active components were 10-hydroxy 2-decenoic acid and 10-hydroxydecanoic acid. These finding may provide a new insight of royal jelly to care disease-oriented state.

Research Products

• [Journal Article] Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures. (2013)
  • Author(s): Inada C, Thi Le X, Tsuneyama K, Fujiwara H, Miyata T, Matsumoto K.
  • Journal Title: Eur J Pharmacol Volume: 699 Pages: 150-159
  • Peer Reviewed
• [Journal Article] Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes (2012)
  • Author(s): Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, Tanaka K, Miyata T, Yokozawa T.
  • Journal Title: BMC Complement Altern Med Volume: 12 Pages: 188-188
  • Peer Reviewed
• [Journal Article] Molecular symmetry and biological activitiesof new symmetrical tris(2-aminoethyl)amine derivatives. (2012)
  • Author(s): Mibu N, Yokomizo K, Uchida W, Takemura S, Zhou J, Aki H, Miyata T, Sumoto K .
  • Journal Title: Chem Pharm Bull Volume: 60 Pages: 408-414
  • Peer Reviewed
• [Journal Article] New spirostanol glycosides from Solanum nigrum and S. (2012)
  • Author(s): Ohno M, Murakami K, El-Aasr M, Zhou JR, Yokomizo K, Ono M, Nohara T.
  • Journal Title: J Nat Med Volume: 66 Pages: 658-663
  • Peer Reviewed
• [Journal Article] 未病のトランスレーショナルリサーチ (2012)
  • Author(s): 宮田 健
  • Journal Title: 崇城大学紀要 Volume: 37 Pages: 149-158
  • NAID: 40019227997
  • Peer Reviewed
• [Journal Article] New spirostanol glycosides from Solanum nigrum and S. jasminoides (2012)
  • Author(s): Ohno M
  • Journal Title: J Nat Med Volume: 66 Issue: 4 Pages: 658-663
  • DOI: 10.1007/s11418-012-0637-z
  • Peer Reviewed
• [Journal Article] 未病のトランスレーショナルリサーチ (2012)
  • Author(s): 宮田健
  • Journal Title: 崇城大学紀要 Volume: 第37巻 Pages: 149-158
  • NAID: 40019227997
  • Peer Reviewed
• [Journal Article] Diabetes-induced centralcholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription (2011)
  • Author(s): Zhao Q, Matsumoto K, Tsuneyama K, Tanaka K, Li F, Shibahara N, Miyata T, Yokozawa T.
  • Journal Title: J Pharmacol Sci Volume: 117 Pages: 230-242
  • Peer Reviewed
• [Journal Article] Synthesis and antiviral activities of some N-acyl-2,6-diaminopyridines and related linker mode identical twin drugs. (2011)
  • Author(s): Mibu N, Yokomizo K, Saisho M, Oishi M, Aki H, Miyata T, Sumoto K.
  • Journal Title: Heterocycles Volume: 83 Pages: 385-393
  • Peer Reviewed
• [Journal Article] Ameliorative effects ofyokukansan on learning and memorydeficits in olfactory bulbectomized mice. (2011)
  • Author(s): Yamada M, Hayashida M, Zhao Q, Shibahara N, Tanaka K, Miyata T, Matsumoto K.
  • Journal Title: J Ethnopharmacol Volume: 135 Pages: 737-746
  • Peer Reviewed
• [Journal Article] Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic (2011)
  • Author(s): Zhao Q, Yokozawa T, Tsuneyama K, Tanaka K, Miyata T, Shibahara N, Matsumoto K
  • Journal Title: Chin Med Volume: 6 Pages: 33-33
  • Peer Reviewed
• [Journal Article] Identification and characterization of component organic and glycosidic acids of crude resin glycoside fraction from Calystegia soldanella. (2011)
  • Author(s): Takigawa A, Setoguchi H, Okawa M, Kinjo J, Miyashita H, Yokomizo K,Yoshimitsu H, Nohara T, Ono M.
  • Journal Title: Chem Pharm Bull Volume: 59 Pages: 1163-1168
  • NAID: 130001852319
  • Peer Reviewed
• [Journal Article] Novel approach to curatives of Mibyou . (2011)
  • Author(s): Miyata T.
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 1289-1298
  • Peer Reviewed
• [Journal Article] Novel Approach to Curatives of Mibyou (Presymptomatic Diseases) (2011)
  • Author(s): Miyata T
  • Journal Title: YAKUGAKU ZASSHI Volume: 131 Issue: 9 Pages: 1289-1298
  • DOI: 10.1248/yakushi.131.1289
  • NAID: 40018967171
  • ISSN: 0031-6903, 1347-5231
  • Peer Reviewed
• [Journal Article] Identification and Characterization of Component Organic and Glycosidic Acids of Crude Resin Glycoside Fraction from Calystegia soldanella (2011)
  • Author(s): Takigawa A
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 59 Issue: 9 Pages: 1163-1168
  • DOI: 10.1248/cpb.59.1163
  • NAID: 130001852319
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro. (2010)
  • Author(s): Nishimoto Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y.
  • Journal Title: J Pharma Sci Volume: 113 Pages: 76-83
  • NAID: 10027745175
  • Peer Reviewed
• [Journal Article] Low direct cytotoxicity of loxoprofen on gastric mucosal cells. (2010)
  • Author(s): Yamakawa N, Suemasu S, Kimoto A, Arai Y, Ishihara T, Yokomizo K, Okamoto Y, Otsuka M, Tanaka K, Mizushima T.
  • Journal Title: Biol Pharm Bull Volume: 33 Pages: 398-403
  • NAID: 130000248088
  • Peer Reviewed
• [Journal Article] HSP70 inducers from Chinese herbs and their effect onmelanin production. (2010)
  • Author(s): Yamashita Y, Hoshino T, Matsuda M, Kobayashi C, Tominaga A, Nakamura Y, Nakashima K, Yokomizo K, Ikeda T, Mineda K, Maji D, Niwano Y, Mizushima T
  • Journal Title: Exp Dermatol. Volume: 19 Pages: 340-342
  • Peer Reviewed
• [Journal Article] Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro. (2010)
  • Author(s): Nishimoto Y(第一著者名)
  • Journal Title: J Pharmacol Sci Volume: 113 Pages: 76-83
  • Peer Reviewed
• [Journal Article] HSP70 inducers from Chinese herbs and their effect on melanin production. (2010)
  • Author(s): Yamashita Y(第一著者名)
  • Journal Title: Exp Dermatol Volume: 19 Pages: 340-342
  • Peer Reviewed
• [Journal Article] Synthesis and antiviral activities of some heteroaryl-substituted triarylmethanes. (2010)
  • Author(s): Mibu N(第一著者名)
  • Journal Title: J Heterocyclic Chem Volume: 47 Pages: 1434-1438
  • Peer Reviewed
• [Presentation] Polyherb supplement 美露仙寿の冷えに対する効果 (2012)
  • Author(s): 横溝和美
  • Organizer: 第19回日本未病システム学会学術総会
  • Place of Presentation: 金沢
• [Presentation] Polyherb supplementの抗腫瘍効果と腸内フローラ改善効果 (2011)
  • Author(s): 横溝和美
  • Organizer: 日本未病システム学会
  • Place of Presentation: 今池ガスビル(名古屋市)
  • Year and Date: 2011-11-20
• [Presentation] Roles of antioxidants and heat shock protein induces as an antifatigue effects induced by health supplements (2010)
  • Author(s): 横溝和美,周 建融,宮田 健
  • Organizer: BIT's 8thAnnual Congress of International Drug Discovery Sciences and Technology
  • Place of Presentation: 北京(中国)
  • Year and Date: 2010-10-26
• [Presentation] Molecular Pharmacological Evaluation of Maimendongtang, as an Example Strategy toward implementing Kampo into Modem Japon Medicine. (2010)
  • Author(s): 宮田健
  • Organizer: 5th International Congress of the International Society for History of Islamic Medicine
  • Place of Presentation: イスタンブール
  • Year and Date: 2010-10-26