The mechanism by which rikkunshito increases acylated ghrelin
Project/Area Number |
22590676
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Hokkaido University |
Principal Investigator |
TAKEDA Hiroshi 北海道大学, 大学院・薬学研究院, 教授 (60261294)
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | グレリン・漢方 / グレリン / GOAT / 漢方薬 / 六君子湯 |
Research Abstract |
This study was conducted to uncover the mechanism by which rikkunshito increases plasma acylatedto desacyl-ghrelin ratio in cisplatin-treated rats. Several components of rikkunsito including 10-gingeroldemonstrated inhibitory activity against ghrelin deacylating enzyme, carboxylesterase. Furthermore,stably transfected GOAT/ preproghrelin HEK 293 cells were successfully established to explore theeffects of rikkunshito on ghrelin producing machinery.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test.2013
Author(s)
Hata T, Kato M, Kudo T, Nishida M, Nishida U, Imai A, Yoshida T, Hirota J, Kamada G, Ono S, Nakagawa M, Nakagawa S, Shimizu Y, Takeda H, Asaka M.
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Journal Title
Digestion.
Volume: 87
Pages: 34-39
NAID
Related Report
Peer Reviewed
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[Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin -induced anorexia by inhibiting acylated ghrelin degradation.2011
Author(s)
Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H.
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Journal Title
Biochem Biophys Res Commun.
Volume: 412
Pages: 506-511
Related Report
Peer Reviewed
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[Journal Article] Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling.2011
Author(s)
Saegusa Y, Takeda H, Muto S, Oridate N, Nakagawa K, Sadakane C, Nahata M, Harada Y, Iizuka M, Hattori T, Asaka M.
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Journal Title
Biol Pharm Bull.
Volume: 34
Pages: 704-711
NAID
Related Report
Peer Reviewed
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[Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation2011
Author(s)
Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H
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Journal Title
Biochem Biophys Res Commun
Volume: 412
Issue: 3
Pages: 506-511
DOI
Related Report
Peer Reviewed
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[Presentation] 社会的ストレスと消化器症状2012
Author(s)
武田宏司、武藤修一、大西俊介
Organizer
第78回消化器心身医学研究会(シンポジウム)
Place of Presentation
パークハイアット東京(東京)
Year and Date
2012-04-20
Related Report
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[Presentation] Impaired Gastric Emptying in Gastroesophageal Reflux Disease Rat Models is Caused by a Reduced Response to Ghrelin.2011
Author(s)
Takeda H, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Asaka M.
Organizer
DDW2011
Place of Presentation
McCormick Place(米国イリノイ州シカゴ市)
Year and Date
2011-05-08
Related Report
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[Presentation] 食欲不振に対する六君子湯の効果2010
Author(s)
武田宏司、武藤修一、大西俊介、浅香正博
Organizer
第12回日本神経消化器病学会総会(シンポジウム)
Place of Presentation
城山観光ホテル(鹿児島県鹿児島市)
Year and Date
2010-10-01
Related Report
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