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The mechanism by which rikkunshito increases acylated ghrelin

Research Project

Project/Area Number 22590676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHokkaido University

Principal Investigator

TAKEDA Hiroshi  北海道大学, 大学院・薬学研究院, 教授 (60261294)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsグレリン・漢方 / グレリン / GOAT / 漢方薬 / 六君子湯
Research Abstract

This study was conducted to uncover the mechanism by which rikkunshito increases plasma acylatedto desacyl-ghrelin ratio in cisplatin-treated rats. Several components of rikkunsito including 10-gingeroldemonstrated inhibitory activity against ghrelin deacylating enzyme, carboxylesterase. Furthermore,stably transfected GOAT/ preproghrelin HEK 293 cells were successfully established to explore theeffects of rikkunshito on ghrelin producing machinery.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (47 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 13 results) Presentation (30 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Serotonin 2Creceptor antagonism ameliorates novelty- induced hypophagia in aged mice.2013

    • Author(s)
      Nahata M, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Saegusa Y, Iizuka S, Hattori T, Asaka M, Takeda H.
    • Journal Title

      Psychoneuroendocrinology.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in ghrelin-related factors in gastroesophageal reflux disease in rats.2013

    • Author(s)
      Nahata M, Saegusa Y, Harada Y, Tsuchiya N, Hattori T, Takeda H.
    • Journal Title

      Gastroenterology Research and Practice.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cisplatin-induced anorexia and ghrelin.2013

    • Author(s)
      Hattori T, Yakabi K, Takeda H.
    • Journal Title

      Vitam Horm

      Volume: 92 Pages: 301-317

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test.2013

    • Author(s)
      Hata T, Kato M, Kudo T, Nishida M, Nishida U, Imai A, Yoshida T, Hirota J, Kamada G, Ono S, Nakagawa M, Nakagawa S, Shimizu Y, Takeda H, Asaka M.
    • Journal Title

      Digestion.

      Volume: 87 Pages: 34-39

    • NAID

      120005228164

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rikkunshito and ghrelin secretion.2012

    • Author(s)
      Takeda H, Muto S, Nakagawa K, Ohnishi S, Asaka M.
    • Journal Title

      Curr Pharm Des.

      Volume: 18 Pages: 4827-4838

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rikkunshito as a ghrelin enhancer.2012

    • Author(s)
      Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
    • Journal Title

      Methods Enzymol.

      Volume: 514 Pages: 333-351

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease.2012

    • Author(s)
      Nahata M, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Hattori T, Asaka M, Takeda H.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 303

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of carbon dioxide-insufflating colonoscopy in patients with irritable bowel syndrome (IBS): a randomized double-blind study.2012

    • Author(s)
      Imai A, Kato M, Ono S, Shimizu Y, Takeda H, Asaka M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 27 Pages: 1623-1628

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin -induced anorexia by inhibiting acylated ghrelin degradation.2011

    • Author(s)
      Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 412 Pages: 506-511

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased plasma ghrelin contributes to anorexia following novelty stress.2011

    • Author(s)
      Saegusa Y, Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Nahata M, Hattori T, Asaka M.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 301

    • NAID

      130004626089

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling.2011

    • Author(s)
      Saegusa Y, Takeda H, Muto S, Oridate N, Nakagawa K, Sadakane C, Nahata M, Harada Y, Iizuka M, Hattori T, Asaka M.
    • Journal Title

      Biol Pharm Bull.

      Volume: 34 Pages: 704-711

    • NAID

      130000657784

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased plasma ghrelin contributes to anorexia following novelty stress2011

    • Author(s)
      Saegusa Y, Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Nahata M, Hattori T, Asaka M
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 301 Issue: 4 Pages: E685-E696

    • DOI

      10.1152/ajpendo.00121.2011

    • NAID

      130004626089

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation2011

    • Author(s)
      Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Issue: 3 Pages: 506-511

    • DOI

      10.1016/j.bbrc.2011.08.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition.2010

    • Author(s)
      Takeda H, Muto S, Hattori T, Sadakane C, Tsuchiya K, Katsurada T, Ohkawara T, Oridate N, Asaka M.
    • Journal Title

      Endocrinology.

      Volume: 151 Pages: 244-252

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機能性ディスペプシアおよび食欲不振に対する漢方治療2010

    • Author(s)
      武田宏司, 武藤修一, 大西俊介, 浅香正博
    • Journal Title

      日本消化器病学会雑誌

      Volume: 107 Pages: 1586-1591

    • NAID

      10027493726

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 消化器疾患に対する心身医学的アプローチ高齢者における食欲不振の病態2010

    • Author(s)
      武田宏司, 武藤修一
    • Journal Title

      日本医事新報

      Volume: 4500 Pages: 76-80

    • NAID

      40017200498

    • Related Report
      2010 Annual Research Report
  • [Presentation] 機能性消化管障害の病態生理と治療戦略2013

    • Author(s)
      武田宏司
    • Organizer
      第9回日本消化管学会総会(ランチョンセミナー)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2013-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] グレリンシグナルの低下がGERDにおける胃排出低下に関与する2012

    • Author(s)
      武田宏司、武藤修一、大西俊介
    • Organizer
      JDDW2012(シンポジウム)
    • Place of Presentation
      神戸国際会議場他(兵庫県神戸市)
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] セロトニン、グレリンシグナルと食欲の異常2012

    • Author(s)
      武田宏司
    • Organizer
      第16回活性アミンに関するワークショップ
    • Place of Presentation
      北海道医療大学(北海道札幌市)
    • Year and Date
      2012-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌患者における食欲不振のメカニズム2012

    • Author(s)
      武田宏司
    • Organizer
      第53回日本心身医学会総会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2012-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] A Study on Gender Differences in Feeding Behavior and Plasma Acyl Ghrelin Levels in Aged Mice Following Exposure to a Novel Environmental Stress.2012

    • Author(s)
      Ohnishi S, Takeda H, Muto S, Nakagawa K, Sadakane C, Nahata M, Saegusa Y, Hattori T, Asaka M.
    • Organizer
      DDW2012.
    • Place of Presentation
      San Diego Convention Center(米国カリフォルニア州サンディエゴ市)
    • Year and Date
      2012-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] The Ghrelin Enhancer Rikkunshito Improves Gastric Dysmotility in Restraint Stress Mice.2012

    • Author(s)
      Takeda H, Muto S, Ohnishi S, Nakagawa K, Nahata M, Saegusa Y, Sadakane C, Hattori T, Asaka M.
    • Organizer
      DDW2012.
    • Place of Presentation
      San Diego Convention Center(米国カリフォルニア州サンディエゴ市)
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Potential New Treatment to Alleviate Stress-Induced Anorexia.2012

    • Author(s)
      Muto S, Takeda H, Ohnishi S, Nakagawa K, Saegusa Y, Nahata M, Sadakane C, Hattori T, Asaka M.
    • Organizer
      DDW2012
    • Place of Presentation
      San Diego Convention Center(米国カリフォルニア州サンディエゴ市)
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Stress-Related Differences in Appetite-Related Genes Between Advanced-Age Male and Female Mice.2012

    • Author(s)
      Muto S, Takeda H, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
    • Organizer
      DDW2011
    • Place of Presentation
      McCormick Place(米国イリノイ州シカゴ市)
    • Year and Date
      2012-05-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会的ストレスと消化器症状2012

    • Author(s)
      武田宏司、武藤修一、大西俊介
    • Organizer
      第78回消化器心身医学研究会(シンポジウム)
    • Place of Presentation
      パークハイアット東京(東京)
    • Year and Date
      2012-04-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 性差が末梢グレリン分泌に与える影響2012

    • Author(s)
      大西俊介、武藤修一、武田宏司
    • Organizer
      98回日本消化器病学会(ワークショップ)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 新奇環境ストレスによる食欲不振は血中グレリン低下が原因である2012

    • Author(s)
      武藤修一、大西俊介、武田宏司
    • Organizer
      第8回日本消化管学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2012-02-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 六君子湯の食欲改善作用のメカニズム2011

    • Author(s)
      武田宏司、武藤修一、大西俊介
    • Organizer
      第13回日本神経消化器病学会総会(シンポジウム)
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 六君子湯は社会的隔離による食欲不振を改善する2011

    • Author(s)
      武田宏司,武藤修一,大西俊介
    • Organizer
      第97回日本消化器病学会総会(ワークショップ)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 六君子湯は社会的隔離による食欲不振を改善する2011

    • Author(s)
      武田宏司, 武藤修一, 大西俊介
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novelty Stress-Induced Anorexia is Due to the Decrease in the Plasma Ghrelin Level via 5-HT1b/2C-Melanocortin4 System Activation.2011

    • Author(s)
      Muto S, Takeda H, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
    • Organizer
      DDW2011
    • Place of Presentation
      McCormick Place(米国イリノイ州シカゴ市)
    • Year and Date
      2011-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Potential New Treatment to Alleviate Chemotherapy Anorexia.2011

    • Author(s)
      Ohnishi S, Takeda H, Muto S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
    • Organizer
      DDW2011
    • Place of Presentation
      McCormick Place(米国イリノイ州シカゴ市)
    • Year and Date
      2011-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Impaired Gastric Emptying in Gastroesophageal Reflux Disease Rat Models is Caused by a Reduced Response to Ghrelin.2011

    • Author(s)
      Takeda H, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Asaka M.
    • Organizer
      DDW2011
    • Place of Presentation
      McCormick Place(米国イリノイ州シカゴ市)
    • Year and Date
      2011-05-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Influence of Gender on Peripheral Ghrelin Secretion-Examination in the Aging Mice-.2011

    • Author(s)
      Ohnishi S, Takeda H, Muto S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
    • Organizer
      DDW2011
    • Place of Presentation
      McCormick Place(米国イリノイ州シカゴ市)
    • Year and Date
      2011-05-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 腹部膨満の病態と大建中湯の役割2011

    • Author(s)
      武田宏司、加藤寛士、浅香正博
    • Organizer
      第7回日本消化管学会総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2011-02-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 加齢による食欲不振のメカニズムとその対策2010

    • Author(s)
      武藤修一、平山剛、武田宏司
    • Organizer
      JDDW2010(シンポジウム)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2010-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 消化器疾患と六君子湯・大建中湯2010

    • Author(s)
      武田宏司
    • Organizer
      第12回日本神経消化器病学会(市民講座)
    • Place of Presentation
      鹿児島大学稲盛会館(鹿児島県鹿児島市)
    • Year and Date
      2010-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 食欲不振に対する六君子湯の効果2010

    • Author(s)
      武田宏司、武藤修一、大西俊介、浅香正博
    • Organizer
      第12回日本神経消化器病学会総会(シンポジウム)
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Year and Date
      2010-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Social Isolation After Anorexia is Mediated by Abnormalities in Serotonin 2C Receptor Reactivity.2010

    • Author(s)
      Sadakane C, Takeda H, Saegusa Y, Hattori T, Nakagawa K, Muto S, Asaka M.
    • Organizer
      DDW2010.
    • Place of Presentation
      The Ernest N. Morial Convention Center(米国ルイジアナ州ニューオリンズ市)
    • Year and Date
      2010-05-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Ghrelin Alleviates Social Isolation-Associated Anorexia in Mice.2010

    • Author(s)
      Saegusa Y, Takeda H, Sadakane C, Hattori T, Katsurada T, Muto S, Asaka M.
    • Organizer
      DDW2010.
    • Place of Presentation
      The Ernest N. Morial Convention Center(米国ルイジアナ州ニューオリンズ市)
    • Year and Date
      2010-05-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 消化器癌化学療法にともなう食欲不振のメカニズムとその対策2010

    • Author(s)
      武藤修一、武田宏司、浅香正博
    • Organizer
      第96回日本消化器病学会総会シンポジウム
    • Place of Presentation
      新潟市朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2010-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 食欲の科学2010

    • Author(s)
      武田宏司
    • Organizer
      第96回日本消化器病学会総会(ランチョンセミナー)
    • Place of Presentation
      新潟市朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2010-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 消化器癌化学療法にともなう食欲不振のメカニズム2010

    • Author(s)
      武藤修一、武田宏司、浅香正博
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] グレリンシグナルの低下がGERDにおける胃排出低下に関与する

    • Author(s)
      武田宏司、武藤修一、大西俊介
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸国際会議場他(兵庫県神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 社会的ストレスと消化器症状

    • Author(s)
      武田宏司
    • Organizer
      第53回日本心身医学会総会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] セロトニン、グレリンシグナルと食欲の異常

    • Author(s)
      武田宏司
    • Organizer
      第16回活性アミンに関するワークショップ
    • Place of Presentation
      北海道医療大学(北海道札幌市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.pharm.hokudai.ac.jp/byoutai/index.html

    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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