The molecular pathogenesis of hepatocellular carcinoma

• Project/Area Number: 22590715
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Chiba University
• Principal Investigator: KANAI Fumihiko 千葉大学, 大学院・医学研究院, 講師 (70334399)
• Co-Investigator(Kenkyū-buntansha): TADA Motohisa 千葉大学, 医学部附属病院, 助教 (00554239)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肝臓学 / 肝細胞癌 / オリゴヌクレオチドアレイ / ヘッジホッグシグナル

Research Abstract

We analyzed the alteration of Hedgehog and Hippo signal in hepatocelluar carcinoma based on the results which was already detected by comprehensive analysis of genomic alteration using SNP array. We detected Hedgehog interacting protein, Suppresor of fused, and Sarvador homolog 1 was involved in the hepatocarcinogenesis and progression of hepatocellular carcinoma.

Research Products

• [Journal Article] Altered Composition of Fatty Acids Exacerbates Hepatotumorigenesis during Activation of the Phosphatidylinositol 3-kinase Pathway (2011)
  • Author(s): Kanai F, Tada M et al
  • Journal Title: J Hepatol Volume: 55 Pages: 1400-1408
  • Peer Reviewed
• [Journal Article] Altered composition of fetty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway (2011)
  • Author(s): Yotaro Kudo, Fumihiko Kanai, Motohisa Tada, et al.
  • Journal Title: Journal of Hepatology Volume: 55 Pages: 1400-1408
  • Peer Reviewed
• [Presentation] 肝細胞癌におけるHippoシグナルの異常に関する検討 (2011)
  • Author(s): 浅岡良成、金井文彦、多田素久, 他
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: ホテルグランパシフィックLEDAIBA
  • Year and Date: 2011-06-03
• [Presentation] 肝細胞癌におけるHippoシグナルの異常に関する検討 (2011)
  • Author(s): 浅岡良成、金井文彦、多田素久, 他
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: ホテルグランパシフィックLE DAIBA
  • Year and Date: 2011-06-03
• [Presentation] 肝発癌、進展におけるHedgehogsignalの関与と新規治療の探索 (2010)
  • Author(s): 多田素久, 他
  • Organizer: 第18回日本消化器病関連学会週間
  • Place of Presentation: パシフィコ横浜会議センター
  • Year and Date: 2010-10-15
• [Presentation] 肝発癌、進展におけるHedgehog signalの関与と新規治療の探索 (2010)
  • Author(s): 多田素久
  • Organizer: 第18回日本消化器病関連学会週間
  • Place of Presentation: パシフィコ横浜会議センター
  • Year and Date: 2010-10-15