| Project/Area Number |
22590716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
IKEDA Hitoshi 東京大学, 医学部附属病院, 准教授 (80202422)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMIYA Tomoaki 東京大学, 医学部附属病院, 特任講師 (90227637)
中川 勇人 東京大学, 医学部附属病院, 医員 (00555609)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
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| Keywords | 肝臓学 / スフィンゴシン1リン酸 / 門脈圧亢進症 |
|---|
| Research Abstract |
Portal hypertension is well known as one of critical complications of liver cirrhosis. We have successfully treated portal hypertension in rodent models by inhibiting an effect of sphingosine 1-phosphate, a lipid mediator, with its receptor antagonist. Because our strategy had minimal side effects such as a reduction of arterial pressure, its application in human should be further examined.
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