Development of immunotherapy for hepatocellular carcinoma by peptide vaccine
| Project/Area Number |
22590723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ELISPOTアッセイ / ヘルパーT細胞 / ペプチド / ワクチン / 免疫治療 / 肝細胞癌 / CTL / AFP / 肝細胞がん / hTERT / エピトープ |
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| Research Abstract |
In the present study, we tried to develop immunotherapy for hepatocellular carcinoma (HCC) by peptide vaccine. The following results were obtained from this study. 1) The helper T cell (HTL) epitopes in AFP and hTERT were identified. 2) Immune responses against these HTL epitopes in peripheral blood mononuclear cells of HCC patients were observed. 3) Peptide vaccines encoding amino acid sequences in the HTL epitopes were developed based on the above results.
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Report
(4 results)
Research Products
(20 results)
