The development of method for liver fibrosis inhibition by controlling liver fibrosis
Project/Area Number |
22590727
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Osaka City University (2012) Kyoto University (2010-2011) |
Principal Investigator |
MURAKAMI Yoshiki 大阪市立大学, 大学院・医学研究科, 病院講師 (00397556)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | マイクロ RNA / 肝線維化 / 肝発癌 / miRNA / マイクロRNA / 慢性C型肝炎 / 肝細胞癌 / エクソソーム / C型肝炎ウイルス |
Research Abstract |
Liver fibrosis in chronic liver disease was progressed without suitable medical treatment. We clarified the microRNA (miRNA) of which aberrant expression was related to the progression of liver fibrosis by using microarray analysis in liver
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis BMC Cancer2013
Author(s)
Murakami Y, Tamori A, Itami S, Tanahashi T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A,Kumada T, Kawada N, Kubo S and Kuroda M
Volume
13
Pages
99-99
Related Report
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[Journal Article] A Phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin in cancer patients.2013
Author(s)
Kanai M,Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.
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Journal Title
Cancer Chemotherapy and Pharmacology (in press)
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis2013
Author(s)
Murakami Y, Tamori A, Itami S, Tanahashi T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A, Kumada T, Kawada N, Kubo S and Kuroda M.
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 99-99
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells2012
Author(s)
Kurokawa K, Tanahashi T, Iima T, Yamamoto Y, Akaike Y, Nishida K, Masuda K, Kuwano Y, Murakami Y, Fukushima M, Rokutan
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Journal Title
J Gastroenterol
Volume: 47
Issue: 8
Pages: 883-895
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C2011
Author(s)
Onomoto K, Morimoto S, Kawaguchi T, Toyoda H, Tanaka M, Kuroda M, Uno K, Kumada T, Matsuda F, Shimotohno K, Fujita T, and Murakami Y
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Journal Title
NAID
Related Report
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[Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development2010
Author(s)
Shigoka M, Tsuchida A, Matsudo T, Nagakawa Y, Saito S, Suzuki Y, Aoki T, Murakami Y, Toyoda H, Kumada T, Bartenschlager R, Kato N, Ikeda M, Takashina T, Tanaka M, Suzuki R, Oikawa K, Takanashi M, Kuroda M
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Journal Title
Pathol Int
Volume: 60
Pages: 351-357
NAID
Related Report
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