To develop a new immune therapy for post liver transplantation hepatitis C.

• Project/Area Number: 22590735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Okayama University
• Principal Investigator: TAKAKI Akinobu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80359885)
• Co-Investigator(Kenkyū-buntansha): YAGI Takahito 岡山大学, 岡山大学病院, 教授 (00304353) ; WATANABE Nobukazu 東京大学, 医科学研究所, 准教授 (10334278)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肝臓移植 / C型肝炎 / 制御性T細胞 / 肝移植 / 免疫応答 / マイクロキメリズム解析

Research Abstract

Immune regulation related molecule PD-L2 expression in the liver biopsy specimens and regulatory T cell frequency in peripheral blood were analyzed in post transplantation hepatitis C patients. The PD-L2 expression in the liver specimen was stronger in post-transplantation hepatitis C patients than other etiology. The regulatory T cell frequency was higher in severe hepatitis C recurrent patients. We found that these immune regulatory molecules could be the target to reduce post-transplantation severe hepatitis C recurrence.

Research Products

• [Presentation] Sequential changes of regulatory T cell fraction after liver transplantation (2012)
  • Author(s): Takaki A, Koike K, Yagi T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Utsumi M, Yasunaka T, Fujiwara T, Yamamoto K
  • Organizer: AASLD2012
  • Place of Presentation: Boston, USA
• [Presentation] Low frequency of Tr1 in peripheral blood correlated with persistent normal ALT in chronic hepatitis C after liver transplantation (2012)
  • Author(s): Koike K, Takaki A, Yagi T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Utsumi M, Yasunaka T, Yamamoto K
  • Organizer: UEGW2012
  • Place of Presentation: Amsterdam, Holland
• [Presentation] Sequential changes of regulatory T cell fraction after liver transplantation. (2012)
  • Author(s): 高木章乃夫
  • Organizer: American Association for the Society of Liver Disease.2012.
  • Place of Presentation: Boston,USA
• [Presentation] Low frequency of Tr1 in peripheral blood correlated with persistent normal ALT in chronic hepatitis C after liver transplantation (2012)
  • Author(s): 小池和子（高木章乃夫）
  • Organizer: United European Gastroenterology Week.2012.
  • Place of Presentation: Amsterdam,Holland
• [Presentation] 移植後肝疾患における末梢血制御性T細胞の頻度の検討 (2011)
  • Author(s): 内海方嗣
  • Organizer: 第29回肝移植研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-07-22
• [Presentation] C型肝炎ウイルス蛋白による樹状細胞機能変化の検討 (2010)
  • Author(s): 高木章乃夫,小池和子,山本和秀
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-22
• [Presentation] Costimulatory molecule PD-L2 is expressed in the hepatocytes of patients with recurrent hepatitis C after liver transplantation (2010)
  • Author(s): Takaki A, Koike K, Yagi T, Iwasaki Y, Sadamori H, Matsuda H, Yasunaka T, Miyake Y, Ikeda F, Kobashi H, Kazuhide Yamamoto
  • Organizer: HCV2010
  • Place of Presentation: Yokohama, Japan