To develop a new immune therapy for post liver transplantation hepatitis C.
Project/Area Number |
22590735
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Okayama University |
Principal Investigator |
TAKAKI Akinobu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80359885)
|
Co-Investigator(Kenkyū-buntansha) |
YAGI Takahito 岡山大学, 岡山大学病院, 教授 (00304353)
WATANABE Nobukazu 東京大学, 医科学研究所, 准教授 (10334278)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 肝臓移植 / C型肝炎 / 制御性T細胞 / 肝移植 / 免疫応答 / マイクロキメリズム解析 |
Research Abstract |
Immune regulation related molecule PD-L2 expression in the liver biopsy specimens and regulatory T cell frequency in peripheral blood were analyzed in post transplantation hepatitis C patients. The PD-L2 expression in the liver specimen was stronger in post-transplantation hepatitis C patients than other etiology. The regulatory T cell frequency was higher in severe hepatitis C recurrent patients. We found that these immune regulatory molecules could be the target to reduce post-transplantation severe hepatitis C recurrence.
|
Report
(4 results)
Research Products
(7 results)
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[Presentation] Sequential changes of regulatory T cell fraction after liver transplantation2012
Author(s)
Takaki A, Koike K, Yagi T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Utsumi M, Yasunaka T, Fujiwara T, Yamamoto K
Organizer
AASLD2012
Place of Presentation
Boston, USA
Related Report
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[Presentation] Low frequency of Tr1 in peripheral blood correlated with persistent normal ALT in chronic hepatitis C after liver transplantation2012
Author(s)
Koike K, Takaki A, Yagi T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Utsumi M, Yasunaka T, Yamamoto K
Organizer
UEGW2012
Place of Presentation
Amsterdam, Holland
Related Report
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[Presentation] Costimulatory molecule PD-L2 is expressed in the hepatocytes of patients with recurrent hepatitis C after liver transplantation2010
Author(s)
Takaki A, Koike K, Yagi T, Iwasaki Y, Sadamori H, Matsuda H, Yasunaka T, Miyake Y, Ikeda F, Kobashi H, Kazuhide Yamamoto
Organizer
HCV2010
Place of Presentation
Yokohama, Japan
Related Report