| Project/Area Number |
22590749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TUJIMURA Toru 兵庫医科大学, 医学部, 教授 (20227408)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 内科 / 臨床 / 癌 / 感染症 / 病理学 / HCV / 肝細胞がん / ミトコンドリア / 粗面小胞体 / ER ストレス / IFN |
|---|
| Research Abstract |
Before and after IFN therapy, liver biopsy tissue was collected from patients with chronic hepatitis C. Analysis of these specimens indicated that patients with an SVR had marked histological improvement according to light microscopy. Electron microscopy (EM) indicated residual defects in mitochondria (MT) in almost of the patients, even if they had an SVR. Moreover, abnormal findings in EM were readily apparent for patients with severe hepatic fibrosis, heavy drinker, fatty liver, and noncancerous liver tissue from patients with hepatocellular carcinoma. The number of base mutations in MT-DNA was determined primarily in the D-loop. The number of base mutations was found to be correlated with morphological defects in MT. As a result of IFN administration, the number of mutations in MT-DNA decreased in all patients.
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