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Establishment of predictors in treatment response of chronic hepatitisC by mutational analysis of internal ribosome entry site within hepatitis C virus

Research Project

Project/Area Number 22590751
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKurume University

Principal Investigator

OGATA Kei  久留米大学, 医学部, 助教 (90309766)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
KeywordsC 型慢性肝炎 / IRES / ペグインターフェロン / リバビリン / 効果予測 / C型慢性肝炎 / HCV / 治療抵抗性 / テラプレビル
Research Abstract

Combination therapy with pegylated interferon and ribavirin (below, PEG/RBV treatment) was performed, and 60 or more cases of Chronic Hepatitis C (below, CH-C), resulting in responders, non-responders and relapsers, were analyzed. An analysis was performed ofthe genetic mutation in the internal ribosome entry site (below, IRES) area of the HCV RNA in each case. In the non-response group, many cases had a history of previous interferon therapy, and in those cases, many cases had no mutations in the IRES domain III (below, d III) area. On the other hand, in the response cases, there was a tendency (P<0.05) for many cases to have mutation in IRES d III. In other words, this indicates that there is a possibility that resistant HCV due to previous antiviral therapy is being selected. In the relapse cases, when an analysis was performed of the IRES base mutation cloned from blood serum at the conclusion of treatment (when negative, by a commercially available HCV RNA qualitative metho), it was found that there was a characteristic mutation in base 119 in the IRES area. In the non-response group and response group for PEG/RBV treatment, when IRES base 119 mutations were compared, a discrepancy was observed between both groups, and furthermore, a correlation was found with HCV core area mutations. In other words, a correlation was indicated between the relationship between HCV IRES base mutations and core mutations, and the treatment results. In the search for thetreatment resistant mechanism as a viral factor, this is believed to be an important finding.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Book (1 results)

  • [Journal Article] The Importance of a Prior Psychiatric Examination in Pegylated Interferon and Ribavirin Combination Treatment for Chronic Hepatitis C.2012

    • Author(s)
      Kuhara K, Ide T, Uchimura N, Kumashiro R, Arinaga T, Miyajima I, Murashima S, Ogata K, Kuwahara R, Fujimoto Y, Sakai K,Ishii K, Morita Y, Shirachi M, Sata M
    • Journal Title

      Kurume Medical Journal

      Volume: Vol.59 Pages: 39-44

    • NAID

      130003368256

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Importance of a Prior Psychiatric Examination in Pegylated Interferon and Ribavirin Combination Treatment for Chronic Hepatitis C2012

    • Author(s)
      Kuhara K, Ide T, Uchimura N, Kumashiro R, Arinaga T, Miyajima I, Murashima S, Ogata K, Kuwahara R, Fujimoto Y, Sakai K, Ishii K, Morita Y, Shirachi M, Sata M
    • Journal Title

      Kurume Medical Journal

      Volume: 59 Pages: 39-44

    • NAID

      130003368256

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C型慢性肝炎におけるインターフェロン治療-治療の工夫とウイルス側要因-2011

    • Author(s)
      井出達也、有永照子、宮島一郎、緒方啓、久原孝一郎、桑原礼一郎、佐田通夫
    • Journal Title

      肝臓フォーラム'10記録集

      Pages: 136-144

    • Related Report
      2010 Annual Research Report
  • [Presentation] Virological characteristics of treatment resistant HCV, examined using blood HCV RNA below the detection sensitivity limits2013

    • Author(s)
      Kei Ogata, Tatsuya Ide, Michio Sata et al
    • Organizer
      23rd Conference of the APASL (Asian Pacific Association for the Study of the Liver)
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre, Singapore
    • Related Report
      2012 Annual Research Report
  • [Presentation] HCVRNA定性陰性のサンプルからクローニングされたHCVのウイルス学的特徴.2012

    • Author(s)
      緒方啓、井出達也、桑原礼一郎、宮島一郎、有永照子、佐田通夫
    • Organizer
      第16回日本肝臓学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-10-10
    • Related Report
      2012 Final Research Report
  • [Presentation] HCV RNA定性陰性のサンプルからクローニングされたHCVのウイルス学的特徴2012

    • Author(s)
      緒方 啓、井出 達也、佐田 通夫他
    • Organizer
      第16回日本肝臓学会大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] HCVIRES領域の変異と治療感受性に関するウイルス学的検討.2011

    • Author(s)
      緒方啓、井出達也、桑原礼一郎、宮島一郎、有永照子、古賀郁利子、神代龍吉、佐田通夫.
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] HCV IRES領域の変異と治療感受性に関するウイルス学的検討2011

    • Author(s)
      緒方啓、井出達也、桑原礼一郎、宮島一郎、有永照子、古賀郁利子、神代龍吉、佐田通夫
    • Organizer
      19th JDDW(第15回日本肝臓学会大会)
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2011 Annual Research Report
  • [Presentation] C型慢性肝疾患における線維化マーカーの年齢による推移2011

    • Author(s)
      井出達也、有永照子、宮島一郎、緒方啓、桑原礼一郎、佐田通夫
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] ワークショップ(5).C型慢性肝炎のインターフェロン治療難治例と予測される症例へのIFNβ1日2回投与と二重慮過血漿交換療法2011

    • Author(s)
      井出達也、有永照子、宮島一郎、緒方啓、桑原礼一郎、佐田通夫
    • Organizer
      第97回日本消化器病学会九州支部例会
    • Place of Presentation
      福岡県久留米市
    • Related Report
      2011 Annual Research Report
  • [Presentation] Strong correlation between mutations in IRES domain III region of hepatitis C virus and sensitivity to anti-viral therapy for chronic hepatitis C.2010

    • Author(s)
      K Ogata, T Ide, M Sata et al
    • Organizer
      第33回日本分子生物 学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Strong correlation between mutations in IRES domain III region of hepatitis C virus and sensitivity to anti-viral therapy for chronic hepatitis C2010

    • Author(s)
      Kei Ogata
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparative study of mutations of HCV IRES is useful for the prediction of the effectiveness of the pegylated interferon/ribavirincombination therapy for chronic hepatitis C.2010

    • Author(s)
      K Ogata, T Ide, M Sata et al
    • Organizer
      第61回米国肝臓学会
    • Place of Presentation
      米国・ボストン
    • Year and Date
      2010-10-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparative study of mutations of HCV IRES is useful for the prediction of the effectiveness of the pegylated interferon/ribavirin combination therapy for chronic hepatitis C2010

    • Author(s)
      Kei Ogata
    • Organizer
      第61回米国肝臓学会
    • Place of Presentation
      米国・ボストン
    • Year and Date
      2010-10-31
    • Related Report
      2010 Annual Research Report
  • [Book] C型慢性肝炎におけるインターフェロン治療‐治療の工夫とウイルス側要因‐肝臓フォーラム'10記録集発行年2011

    • Author(s)
      井出達也、有永照子、宮島一郎、緒方啓、久原孝一郎、桑原礼一郎、佐田通夫.
    • Publisher
      医事出版社
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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