The effect of inhibition of pancreatic fibrosis by IL-10.

• Project/Area Number: 22590758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: OHARA Hirotaka 名古屋市立大学, 大学院・医学研究科, 教授 (80285212)
• Co-Investigator(Kenkyū-buntansha): NAKAZAWA Takahiro 名古屋市立大学, 大学院・医学研究科, 准教授 (70305522) ; ANDOH Tomoaki 名古屋市立大学, 大学院・医学研究科, 研究員 (40423850) ; HAYASHI Kazuki 名古屋市立大学, 大学院・医学研究科, 助教 (00405200) ; NAITOH Itaru 名古屋市立大学, 大学院・医学研究科, 助教 (30527750) ; KANEMATSU Takayoshi 名古屋市立大学, 大学院・医学研究科, 講師 (20381824)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 胆道学 / 膵臓学 / 慢性膵炎 / インターロイキン10 / 酢酸グラチマラ－ / セルレイン膵炎 / IL-10 / MAdCAM-1 / 膵血管内皮細胞 / 遺伝子治療

Research Abstract

Several inflammatory cytokines induced expression of MAdCAM-1 on the vascular endothelial cells of pancreas and increased permeability of endothelium. It was suggested that infiltration of lymphocytes were inhibited by IL-10 because IL-10 inhibited expression of MAdCAM-1. In cerulean-induced pancreatitis model of mice, IL-10-inducing drugs were considered effective against pancreatitis because the increasing of body weight and serum amylase levels of mice ware inhibited by glatiramer acetate which induced expression of IL-10. Consequently, progression of IL-10-inducing drugs are contributable for the therapy of pancreatitis.

Research Products

• [Journal Article] Predictive factors for pancreatitis and cholecystitis in endoscopic covered metal stenting for distal malignant biliary obstruction. (2013)
  • Author(s): Shimizu S, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Kondo H, Yoshida M, Yamashita H, Umemura S, Hori Y, Ohara H, Joh T
  • Journal Title: J Gastroenterol Hepatol Volume: 28(1) Pages: 68-72
  • Peer Reviewed
• [Journal Article] A case of autoimmune pancreatitis showing narrowing of the main pancreatic duct after cessation of steroid therapy in the clinical course. (2012)
  • Author(s): Shimizu S, Naitoh I, Nakazawa T, Hayashi K, Okumura F, Miyabe K, Kondo H, Yoshida M, Yamashita H, Ohara H, Joh T.
  • Journal Title: Intern Med Volume: 51(16) Pages: 2135-2140
  • NAID: 130002062318
  • Peer Reviewed
• [Journal Article] Analysis of VH gene rearrangement and somatic hypermutation in type 1 autoimmune pancreatitis (2012)
  • Author(s): Okumura F, Sakuma H, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Yoshida M, Yamashita H, Ohara H, Inagaki H, Joh T.
  • Journal Title: Pathol Int Volume: 62(5) Pages: 318-323
  • NAID: 10031185207
  • Peer Reviewed
• [Journal Article] Clinical differences between mass-forming autoimmune pancreatitis and pancreatic cancer. (2012)
  • Author(s): Naitoh I, Nakazawa T, Hayashi K, Okumura F, Miyabe K, Shimizu S, Kondoh H, Yoshida M, Yamashita H, Ohara H, Joh T.
  • Journal Title: Scand J Gastroenterol Volume: 47(5) Pages: 607-613
  • Peer Reviewed
• [Journal Article] 経皮経空腸的内視鏡下ドレナージ術が奏功した膵頭十二指腸切除後膵仮性嚢胞の1例. (2011)
  • Author(s): 林 香月、 大原弘隆、 中沢貴宏、吉田道弘、宮部勝之、奥村文浩、内藤 格、宮木知克、安藤朝章、三井 章、城 卓志
  • Journal Title: Gastroenterol Endosc Volume: 53 Pages: 66-72
  • Peer Reviewed
• [Journal Article] Comparative evaluation of the Japanese diagnostic criteria for autoimmune pancreatitis. (2010)
  • Author(s): Naitoh I, Nakazawa T, Ohara H, Ando T, Hayashi K, Okumura F, Miyabe K, Yoshida M, Sano H, Takada H, Kanematsu T, Joh T.
  • Journal Title: Pancreas. Volume: 39(8) Pages: 1173-9
  • Peer Reviewed
• [Journal Article] The revised Japanese clinical diagnostic criteria for chronic pancreatitis. (2010)
  • Author(s): Shimosegawa T, Kataoka K, Kamisawa T, Miyakawa H, Ohara H, Ito T, Naruse S, Sata N, Suda K, Hirota M, Takeyama Y, Shiratori K, Hatori T, Otsuki M, Atomi Y, Sugano K, Tanaka M.
  • Journal Title: J Gastroenterol Volume: 45(6) Pages: 584-91
  • NAID: 10027216435
  • Peer Reviewed
• [Journal Article] Clinical significance of extrapancreatic lesions in autoimmune pancreatitis. (2010)
  • Author(s): Naitoh I, Nakazawa T, Ohara H, Ando T, Hayashi K, Tanaka H, Okumura F, Miyabe K, Yoshida M, Sano H, Takada H, Joh T.
  • Journal Title: Pancreas. Volume: 39(1)
  • Peer Reviewed
• [Journal Article] A case of advanced-stage sclerosing cholangitis with autoimmune pancreatitis not responsive to steroid therapy. (2010)
  • Author(s): Nakazawa T, Naitoh I, Ando T, Hayashi K, Okumura F, Miyabe K, Yoshida M, Ohara H, Joh T.
  • Journal Title: JOP. Volume: 11(1) Pages: 58-60
  • Peer Reviewed
• [Journal Article] 自己免疫性膵炎再治療のポイント肝胆膵 (2010)
  • Author(s): 中沢貴宏、大原弘隆、安藤朝章、今井英人、林 香月、田中創始、内藤 格、奥村文浩、宮部勝之、吉田道弘、高田博樹、佐野 仁、城 卓志
  • Volume: 60
  • Pages: 37-42
  • Peer Reviewed
• [Presentation] 急性閉塞性化膿性膵管炎の臨床像と治療法に関する検討. (2012)
  • Author(s): 奥村文浩、中沢貴宏、大原弘隆
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-12
• [Presentation] 腫瘤形成型自己免疫性膵炎と膵癌の鑑別診断 (2012)
  • Author(s): 内藤 格、中沢貴宏、大原弘隆
  • Organizer: 第97回消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-20
• [Presentation] Clinical differences between mass-forming autoimmune pancreatitis and pancreatic cancer. (2011)
  • Author(s): Naitoh I, Nakazawa T, Hayashi K, Okumura F, Miyabe K, Shimizu S, Yoshida M, Yamashita H, Ohara H, Joh T.
  • Organizer: The International Pancreatic Research Forum 2011.
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2011-11-26
• [Presentation] Significance of obliterative phlebitis for the diagnosis of lymphoplasmacytic sclerosing pancreatitis. (2011)
  • Author(s): Miyabe K, Notohara K, Nakazawa T, Hayashi K, Naitoh I, Okumura F, Shimizu S, Yoshida M, Yamashita H, Ohara H, Joh T.
  • Organizer: The International Pancreatic Research Forum 2011
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2011-11-26
• [Presentation] 急性膵炎にて発症した、乳頭部ポリープ状過形成の 1 例 (2011)
  • Author(s): 宮部勝之、能登原憲司、中沢貴宏、安藤朝章、林 香月、内藤 格、奥村文浩、吉田道弘、大原弘隆、城 卓志
  • Organizer: 第47回日本胆道学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-16
• [Presentation] 当院における早期慢性膵炎診断の現状 (2011)
  • Author(s): 奥村文浩、中沢貴宏、大原弘隆
  • Organizer: 第97回消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] IgG4 関連硬化性胆管炎と原発性硬化性胆管炎の相違点 (2011)
  • Author(s): 内藤 格、中沢貴宏、大原弘隆
  • Organizer: 第97回消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] 自己免疫性膵炎に対する治療と長期予後の検討 (2010)
  • Author(s): 奥村文浩、中沢貴宏、大原弘隆
  • Organizer: JDDW 2010(パネルディスカッション)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 自己免疫性膵炎における膵外病変の有用性 (2010)
  • Author(s): 内藤 格、中沢貴宏、大原弘隆
  • Organizer: 己免疫性膵炎における膵外病変の有用性.日本消化器病学会(ワークショップ)
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23