| Project/Area Number |
22590758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OHARA Hirotaka 名古屋市立大学, 大学院・医学研究科, 教授 (80285212)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZAWA Takahiro 名古屋市立大学, 大学院・医学研究科, 准教授 (70305522)
ANDOH Tomoaki 名古屋市立大学, 大学院・医学研究科, 研究員 (40423850)
HAYASHI Kazuki 名古屋市立大学, 大学院・医学研究科, 助教 (00405200)
NAITOH Itaru 名古屋市立大学, 大学院・医学研究科, 助教 (30527750)
KANEMATSU Takayoshi 名古屋市立大学, 大学院・医学研究科, 講師 (20381824)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 胆道学 / 膵臓学 / 慢性膵炎 / インターロイキン10 / 酢酸グラチマラ－ / セルレイン膵炎 / IL-10 / MAdCAM-1 / 膵血管内皮細胞 / 遺伝子治療 |
|---|
| Research Abstract |
Several inflammatory cytokines induced expression of MAdCAM-1 on the vascular endothelial cells of pancreas and increased permeability of endothelium. It was suggested that infiltration of lymphocytes were inhibited by IL-10 because IL-10 inhibited expression of MAdCAM-1. In cerulean-induced pancreatitis model of mice, IL-10-inducing drugs were considered effective against pancreatitis because the increasing of body weight and serum amylase levels of mice ware inhibited by glatiramer acetate which induced expression of IL-10. Consequently, progression of IL-10-inducing drugs are contributable for the therapy of pancreatitis.
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