| Project/Area Number |
22590798
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 臨床心血管病態学 / 動脈硬化 / プラーク / 急性冠症候群 / 血管内イメージング / 冠動脈 / プラーク破綻 / 材料力学 |
|---|
| Research Abstract |
Rupture of coronary atheroma with subsequent thrombosis is the major cause of acute coronary syndrome. However, exact mechanism of plaque rupture is still unclear. This study was to investigate three-dimensional stereoscopic characteristics to determine whether it leads to acute coronary syndrome or to just a silent rupture, using intravascular imagings. Three dimensional intravascular ultrasound revealed that stereoscopic pattern of atheroma rupture can be classified as shoulder type, longitudinal type, oval type, tunnel type, or multiple type. In our study, longitudinal type was more frequent in patients with acute coronary syndrome compared to silent rupture group. This study therefore suggested that pattern of plaque rupture might determine the prognosis of patients, upon which new insight into mechanism of atherosclerosis、into a new way of assessing plaque vulnerability, or into novel development of therapeutic strategy can be based.
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