Elucidation of significance of TRPM2 in progression of heart failure

• Project/Area Number: 22590810
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: NAKAGAWA Yasuaki 京都大学, 大学院・医学研究科, 助教 (70452357)
• Co-Investigator(Kenkyū-buntansha): KUWAHARA Koichiro 京都大学, 大学院・医学研究科, 講師 (30402887)
• Co-Investigator(Renkei-kenkyūsha): MORI Yasuo 京都大学, 大学院・工学研究科, 教授 (80212265)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 分子心臓病学 / 分子心臓病態学

Research Abstract

Angiotensin II-induced cardiac hypertrophy was suppressed in TRPM2knockout mice. In neonatal rat ventricular myocytes, overexpression of TRPM2 enhancedthe promoter activity of BNP and RCAN1 gene. On the other hand, TRPM2 inhibitor suppressedthe promoter activity of BNP and RCAN1 gene. These data suggested that TRPM2 has anacceleratory effect on cardiac hypertrophy.

Research Products

• [Journal Article] Direct immunochemiluminescent assay for proBNP and total BNPin human plasma proBNP and total BNPlevels in normal and heart failure (2013)
  • Author(s): Nishikimi T, Okamoto H, Nakamura M,Ogawa N, Horii K, Nagata K, NakagawaY, Kinoshita H, Yamada C, Nakao K,Minami T, Kuwabara Y, Kuwahara K,(他4 名)
  • Journal Title: PLoSOne Volume: 8(1)
• [Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure (2013)
  • Author(s): Nishikimi, T., Okamoto, H., Nakamura, M., Ogawa, N., Horii, K., Nagata, K., Nakagawa, Y., Kinoshita, H., Yamada, C., Nakao, K., Minami, T., Kuwabara, Y., Kuwahara, K., Masuda, I., Kangawa, K., Minamino, N., Nakao, K.
  • Journal Title: PLoS ONE Volume: 8(1) Issue: 1 Pages: e53233-e53233
  • DOI: 10.1371/journal.pone.0053233
  • NAID: 120005241437
  • Peer Reviewed
• [Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure (2013)
  • Author(s): Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Minamino N, Nakao K.
  • Journal Title: Heart Volume: 99 Pages: 677-679
  • Peer Reviewed
• [Journal Article] Complexity of melicular formsof B-type natriuretic peptide in heartfailure (2012)
  • Author(s): Nishikimi T, Kuwahara K, NakagawaY
  • Journal Title: Heart
• [Journal Article] Reciprocal expression ofMRTF-A and myocardin in crucial forpathological vascular remodelling inmice (2012)
  • Author(s): Minami T, Kuwahara K, NakagawaY
  • Journal Title: EMBO J Volume: 31(23) Pages: 4428-40
• [Journal Article] Fixed-dosecombination therapy of candesartancilexetile and amlodipine besilate for thetreatment of hypertension in Japan (2012)
  • Author(s): Yasuno S, Fujimoto A, Nakagawa Y,Kuwahara K, Ueshima K
  • Journal Title: Expert Rev cardiovasc Ther Volume: 10(5) Pages: 577-83
• [Journal Article] The effect of glycosylation onfplasm N-terminal proBNP-76 levels inpatients with heart or renal failure (2012)
  • Author(s): Nishikimi T, Ikeda M, Takeda Y,Ishimitus T, Shibasaki I, Fukuda H,Kinoshita H, Nakagwa Y, Kuwahara K,Nakao K
  • Journal Title: Heart Volume: 98(2) Pages: 152-61
• [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice. (2012)
  • Author(s): Minami T, Nakao K, et al
  • Journal Title: EMBO J. Volume: 31 Issue: 23 Pages: 4428-4440
  • DOI: 10.1038/emboj.2012.296
  • Peer Reviewed
• [Journal Article] Fixed-dose combination therapy of candesartan cilexetil and amlodipine besilate for the treatment of hypertension in Japan. (2012)
  • Author(s): Yasuno S, Fujimoto A, Nakagawa Y, Kuwahara K, Ueshima K.
  • Journal Title: Expert Rev Cardiovasc Ther. Volume: 10(5) Issue: 5 Pages: 577-83
  • DOI: 10.1586/erc.12.34
  • Peer Reviewed
• [Journal Article] The effect of glycosylation of plasma N-ternminal proBNP-76 level in patients with heart or renal fialur (2012)
  • Author(s): Nishikimi T, Nakagawa Y, (他8名)
  • Journal Title: Heart Volume: 98 Pages: 152-161
  • Peer Reviewed
• [Journal Article] Zinc-finger protein90 negatively regulates neuron-restritivesilencer factor-mediated transcriptionalrepression of fetal cardiac genes (2011)
  • Author(s): Hata L, Murakami M, Kuwahara K,Nakagawa Y
  • Journal Title: J MolCell Cardiol Volume: 50 (6) Pages: 972-981
• [Journal Article] ミトコンドリア機能を調節する転写ネットワーク (2011)
  • Author(s): 中川靖童、桑原宏一郎、中尾一和
  • Journal Title: 循環器専門医;日本循環器学会専門医雑誌 Volume: 19 Pages: 243-248
• [Journal Article] Zinc-finger protein 90 negatively regulates neuron-restritive silencer factor-mediated transcriptional repression of fetal cardiac genes. (2011)
  • Author(s): Hata L, Murakami M, Kuwahara K, Nakagawa Y, (他13名)
  • Journal Title: Journal of Cellular and Molecular Cardiology
  • Peer Reviewed
• [Journal Article] Myocardin-relatedtranscriptional factor A is a common mediator ofmechanical stress- and neurohumoralstimulation-induced cardiac hypertrophicsignaling leading to activation of brain natriureticpeptide gene expression (2010)
  • Author(s): Kuwahara K, Kinoshita H, Kuwabara Y,Nakagawa Y
  • Journal Title: Mol Cel Biol Volume: 30(17) Pages: 4134-48
• [Journal Article] inhibition of TRPC6 channel activity contributes to theantihypertrophic effects of natriureticpeptides-guanylyl cyclase-A signaling in theheart (2010)
  • Author(s): Kinoshita H, Kuwahara K, Nishida M, Rong X,Kiyonaka S, Kuwabara Y, Kurose H, Mori Y, LiY, Nakagawa Y,(他6名)
  • Journal Title: Circ Res Volume: 106(12) Pages: 1849-60
• [Journal Article] Myocardin-related transcriptional factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. (2010)
  • Author(s): Kuwahara K, Nakagawa Y, (他7名)
  • Journal Title: Molecular and Cellular Biology Volume: 30 Pages: 4134-4148
  • Peer Reviewed
• [Journal Article] Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. (2010)
  • Author(s): Kinoshita H, Kuwahara K, Nakagawa Y, (他13名)
  • Journal Title: Circulation Research Volume: 106 Pages: 1849-1860
  • Peer Reviewed
• [Presentation] Glycosylation of plasma N-terminal proBNP andits effect on NT-proBNP assay in hemodyalysispatients (2013)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi,Koichiro Kuwahara 他
  • Organizer: 第77回日本循環器学会学術総会
  • Place of Presentation: パシフィコ横浜 横浜市
• [Presentation] Glycosylation of plasma N-terminal proBNP and its effect on NT-proBNP assay in hemodyalysis patients (2013)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno Y, Kinoshita H, Kuwabara Y, Nakao K, Yamada C, Ueshima K, Nakao K.
  • Organizer: 第77回日本循環器学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] miR‐1を介したRho依存性転写共役因子MRTF‐A発現制御の血管リモデリングにおける意義 (2012)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章他
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-04-23
• [Presentation] Japan Increased HCN channels in failinghearts possibly contribute to ventriculararrhythmias (2012)
  • Author(s): Yoshihiro Kuwabara, KoichiroKuwahara, Makoto Takano, Hideyuki Kinoshita,Yasuaki Nakagawa他
  • Organizer: The76th Annual Scientific Meeting of TheJapanese CirculationSociety
  • Place of Presentation: Fukuoka International Congress Center, Fukuoka
• [Presentation] 血管リモデリングにおける新規治療標的としてのRho依存性転写共役因子MRTF-Aの意義 (2012)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章他
  • Organizer: 第49回日本臨床分子医学会
  • Place of Presentation: 京都
• [Presentation] N-Type Ca2+ Channel Blockade PreventsSudden Death in Mice with Heart Failure (2012)
  • Author(s): Yuko Yamada, Koichiro Kuwahara, HideyukiKinoshita, Yoshihiro Kuwabara, YasuakiNakagawa,他
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 福岡
• [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニン阻害の有用性の検討 (2012)
  • Author(s): 山田 千夏 桑原 宏一郎 中川 靖章 他
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京都
• [Presentation] Reciprocal expression of MRTF-A andmyocardin mediated by miR-1 is crucial forphenotypic modulation of vascular smoothmuscle cells (2012)
  • Author(s): Takeya Minami, KoichiroKuwahara, Yasuaki Nakagawa, 他
  • Organizer: Arteriosclerosis, Thrombosis and VascularBiologyScientific Session 2012(ATVB 2012)
  • Place of Presentation: Chicago
• [Presentation] Direct renin inhibitor prevents ventricularremodeling and sudden arrhythmic death in micewith dilated cardiomyopathy (2012)
  • Author(s): C. Yamada, K.Kuwahara, T. Minami, Y. Kuwabara, K. Nakao,H. Kinoshita, S. Usami, Y. Nakagawa
  • Organizer: 2012 年欧州心臓学会議 (ESC2012)
  • Place of Presentation: Munich, Germany
• [Presentation] Direct ReninInhibitor Strongly Prevents VentricularArrhythmogenic Remodeling and SuddenCardiac Death in Mice with DilatedCardiomyopathy (2012)
  • Author(s): Chinatsu Yamada, KoichiroKuwahara, Yasuaki Nakagawa他
  • Organizer: 2012 年米国心臓病学会議(AHA 2012)
  • Place of Presentation: Los angeles, U.S.A
• [Presentation] 血管リモデリングにおける新規治療標的としてのRho依存性転写共役因子MRTF-Aの意義 (2012)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・錦見俊雄・中尾一和
  • Organizer: 第49回日本臨床分子医学会
  • Place of Presentation: みやこめっせ、 京都
• [Presentation] ｍｉＲ－１を介したＲｈｏ依存性転写共役因子ＭＲＴＦ－Ａ発現制御の血管リモデリングにおける意義 (2012)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・錦見俊雄・中尾一和
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] 拡張型心筋症マウスにおけるN型Ca2+チャネル阻害による自律神経活性調節を介した不整脈突然死予防の有用性 (2012)
  • Author(s): 山田優子、桑原宏一郎、木下秀之、桑原佳宏、中川靖章、柴田純子、山田千夏、南丈也、保野慎治、宇佐美覚、中尾一泰、錦見俊雄、上嶋健治、森泰生、中尾一和
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] 冠動脈CTと負荷心筋SPECTのfusion画像が責任冠動脈病変の同定に有用であった2症例 (2012)
  • Author(s): 桒原佳宏，桑原宏一郎，木下秀之，鷹野誠，中川靖章，宇佐美覚，柴田純子，山田千夏，南丈也，山田優子，保野慎治，錦見俊雄，上嶋健治，中尾一和
  • Organizer: 第113回日循近畿地方会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] 慢性心不全・突然死モデルマウスの不整脈源性基質形成における、レニンーアンジオテンシン系の関与の検討 (2012)
  • Author(s): 山田千夏 桑原宏一郎 木下秀之 桒原佳宏 南丈也 中尾一泰 宇佐美覚 保野慎治 中川靖章 錦見俊雄 上嶋健治 中尾一和
  • Organizer: 第29回日本心電学会学術集会
  • Place of Presentation: 幕張メッセ、千葉
• [Presentation] N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure (2012)
  • Author(s): Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, Yoshihiro Kuwabara, Yasuaki Nakagawa（他10名）
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 九州大学医学部百年講堂
• [Presentation] Reciprocal expression of MRTF-A and Myocardin is crucial for pathological vascular remodeling in mice (2012)
  • Author(s): Takeya Minami, Koichiro Kuwahara, Yasuaki Nakagawa, Hideyuki Kinoshita, Kazuhiro Nakao, Yoshihiro Kuwabara, Toshio Nishikimi, Kazuwa Nakao
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 九州大学医学部百年講堂
• [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニン阻害の有用性の検討 (2012)
  • Author(s): 山田 千夏 桑原 宏一郎 木下 秀之 錦見 俊雄 桑原 佳宏 南 丈也 中尾 一泰 中川 靖章 中尾 一和
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス内
• [Presentation] Increased HCN channels in failing hearts possibly contribute to ventricular arrhythmias (2012)
  • Author(s): Yoshihiro Kuwabara, Koichiro Kuwahara, Yasuaki Nakagawa, (他12名)
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡・福岡国際会議場
• [Presentation] MRTF-A, a rho-dependent co-activator of SRF, plays a critical role in vascular remodeling by regulating smooth muscle cell migra (2012)
  • Author(s): Tsheys Minami, Koichiro Kuwahara Yasuaki Nakagawa, (他13名)
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡・福岡国際会議場
• [Presentation] TRPC3/6 Ion Channels as Potentially Novel Therapeutic Targets against Pulmonary Arterial Hyper (2012)
  • Author(s): Hideyuki Kinoshita Koichiro Kuwahara Yasuaki Makagawa, (他13名)
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡・福岡国際会議場
• [Presentation] Rho 依存性SRF 共役転写因子MRTF-Aは血管リモデリングを制御する (2011)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章 他
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-04-23
• [Presentation] Rho依存性SRF共役転写因子MRTF-Aは血管リモデリングを制御する (2011)
  • Author(s): 南丈也、桑原宏一郎、中川靖童, (他8名)
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸・神戸国際会議場
  • Year and Date: 2011-04-23
• [Presentation] 受容体活性化型Ca2+チャネルTRPC3/6阻害の病的心肥大抑制効果 (2011)
  • Author(s): 木下秀之、桑原宏一郎、中川靖童, (他17名)
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸・神戸国際会議場
  • Year and Date: 2011-04-23
• [Presentation] ANP・BNP遺伝子発現調節因子NRSFの機能阻害による心筋症モデルマウスにおける不整脈発症・突然死に対するHCNチャネル阻害の効果 (2011)
  • Author(s): 棄原佳宏、桑原宏一郎、中川靖童, (他12名)
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸・神戸国際会議場
  • Year and Date: 2011-04-23
• [Presentation] Rho 依存性転写共役因子MRTF-Aによる血管リモデリング制御 (2011)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章 他
  • Organizer: 第40回心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2011-02-04
• [Presentation] 「代謝制御からみた心筋障害・心不全の病態解明 ～基礎から臨床へ～」Implication ofTranscriptional Network RegulatingMitochondrial Function in Heart Failure (2011)
  • Author(s): Yasuaki Nakagawa
  • Organizer: The75th Annual Scientific Meeting of TheJapanese Circulation Society March 18-19 2011
  • Place of Presentation: Pacifico Yokohama, Yokohama Japan
• [Presentation] N-Type Ca2+ ChannelBlockade Prevents Sudden Death in Mice withHeart Failure (2011)
  • Author(s): 山田優子、桑原宏一郎、中川靖章、他
  • Organizer: 第28回日本心電学会学術集会
  • Place of Presentation: 福岡
• [Presentation] N-type Ca2+ channel blockade prevents suddendeath in mice with heart failure (2011)
  • Author(s): Yuko Yamada, Koichiro Kuwahara, Hideyukikinoshita, Yoshihiro Kuwabara, YasuakiNakagawa他
  • Organizer: Basic Cardiovascular Sciences 2010 ScientificSessions
  • Place of Presentation: New Orleans, LO, USA
• [Presentation] HCN channel inhibition with ivabradine preventssudden arrhythmic death in a mouse model ofdilated cardiomyopathy (2011)
  • Author(s): Yoshihiro Kuwabara1,Koichiro Kuwahara, Hideyuki Kinoshita,Yasuaki Nakagawa他
  • Organizer: European Society of Cardiology Congress2011
  • Place of Presentation: Paris, France
• [Presentation] N-type Ca2+channel blockade prevents sudden arrhythmicdeath in ice with heart failure (2011)
  • Author(s): Yuko Yamada,Koichiro Kuwahara, Yasuaki Nakagawa, 他
  • Organizer: 4th Asia Pacific Heart Rhythm SocietyScientific Session (APHRS2011)
  • Place of Presentation: Fukuoka
• [Presentation] Inhibition ofHCN overexpression in failing heart of dilatedcardiomyopathy mouse model by ivabradineprevents sudden arrhythmic death (2011)
  • Author(s): YoshihiroKuwabara, Koichiro Kuwahara, HideyukiKinoshita, Makoto Takano, Yasuaki Nakagawa,他
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, USA
• [Presentation] バセドウ病を合併した滲出性収縮性心膜炎の一例 (2011)
  • Author(s): 山田千夏、桑原宏一郎、中川靖童, (他8名)
  • Organizer: 第22回日本心エコー図学会
  • Place of Presentation: 鹿児島・鹿児島市民文化ホール
• [Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Ca2+チャネル阻害の有用性の検討 (2011)
  • Author(s): 山田優子、桑原宏一郎、中川靖童, (他12名)
  • Organizer: 第34回日本日本高血圧学会総会
  • Place of Presentation: 宇都宮・栃木県総合文化センター
• [Presentation] ANP・BNP遭伝子発現調節因子NRSFにより制御されるHCNチャネルの心不全モデルマウスにおける突然死発症への関与 (2011)
  • Author(s): 棄原佳宏、桑原宏一郎、中川靖童, (他13名)
  • Organizer: 第15回日本心血管内分泌学会
  • Place of Presentation: 大阪・千里ライフサイエンスセンター
• [Presentation] 病的血管リモデリングでみられる血管平滑筋細胞形質転換におけるRho依存性転写共役因子MRTF-Aの意義 (2011)
  • Author(s): 南丈也、桑原宏一郎、中川靖童, (他8名)
  • Organizer: 第15回日本心血管内分泌学会
  • Place of Presentation: 大阪・千里ライフサイエンスセンター
• [Presentation] BNP遺伝子発現調節領域におけるserum response factor応答領域の新たなる同定とその心筋細胞肥大反応における意義 (2011)
  • Author(s): 桑原宏一郎、中川靖童, (他8名)
  • Organizer: 第15回日本心血管内分泌学会
  • Place of Presentation: 大阪・千里ライフサイエンスセンター
• [Presentation] 造影CTで偶発的に発見された右総頸動脈内血栓症の一例 (2010)
  • Author(s): 柴田純子、中川靖章、桑原宏一郎、 他
  • Organizer: 第110回日本循環器学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2010-11-27
• [Presentation] Blockade of TRPC6 is a novel therapeutic approach against pathological cardiac remodeling (2010)
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara, Yasuaki Nakagawa
  • Organizer: 第14回日本心不全学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-07
• [Presentation] T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure (2010)
  • Author(s): 木下秀之、桑原宏一郎、中川靖章
  • Organizer: 第27回日本心電学会学術集会
  • Place of Presentation: 大分
  • Year and Date: 2010-10-06
• [Presentation] バセドウ病を合併した滲出性収縮性心膜炎の1例 (2010)
  • Author(s): 山田千夏,桑原宏一郎,中川靖章,他
  • Organizer: 第192回日本内科学会近畿地方会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2010-09-11
• [Presentation] 甲状腺機能低下を契機に心不全が増悪し多臓器不全に至った放射線治療後収縮性心膜炎の一例 (2010)
  • Author(s): 西尾直子、桑原宏一郎、中川靖章 他
  • Organizer: 第109回日本循環器学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-05
• [Presentation] 新規心肥大治療法としてのTRPC阻害の効果 (2010)
  • Author(s): 木下秀之、桑原宏一郎、中川靖章
  • Organizer: 日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-09
• [Presentation] Essential role of p300 in maintaining mitochondrial gene expression and cell survival in the postnatal heart (2010)
  • Author(s): Yasuaki Nakagawa
  • Organizer: 14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism March
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-04-01
• [Presentation] Rho and actin dynamics-dependent nuclear translocation of MRTF-A is a common molecular mechanisms underlying both mechanical stretch- and neurohumoral stimulation -induced cardiac hypertrophy (2010)
  • Author(s): Koichiro Kuwahara, Yasuaki Nagawa
  • Organizer: 14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism March
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-04-01
• [Presentation] Natriuretic Peptides-Guanylyl Cyclase-A Signaling Pathway Inhibits TR PC6-Mediated Po-Hypertrophic Signaling in the Hearts. (2010)
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara, Yasuaki Nakagawa
  • Organizer: 14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism March
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-04-01
• [Presentation] T-type Ca2+ channel blockade improved survival and arrhythmogenicity in the mouse model of myocardial infarction (2010)
  • Author(s): Yoshihiro Kuwabara, Koichiro Kuwahara, Yasuaki Nakagawa
  • Organizer: 14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism March
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-04-01
• [Presentation] Natriuretic Peptides-Guanylyl Cyclase-ASignaling Pathway Inhibits TRPC6-MediatedPro-Hypertrophic Signaling in the Hearts (2010)
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa 他
  • Organizer: 14th Annual Scientific Session of the Society ofCardiovacular Endocrinology and Metabolism
  • Place of Presentation: Nara
• [Presentation] 「新規心肥大治療法としてのTRPC阻害の効果」 (2010)
  • Author(s): 桑原宏一郎、中川靖章 他
  • Organizer: 第47回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
• [Presentation] Rho依存性転写共役因子myocardin-related transcription factor-Aの心肥大シグナルにおける役割 (2010)
  • Author(s): 桑原宏一郎、中川靖章 他
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
• [Presentation] Blockade of TRPC6 is anovel therapeutic approach against pathologicalcardiac remodeling (2010)
  • Author(s): Hideyuki Kinoshita,Koichiro Kuwahara, Yasuaki Nakagawa他
  • Organizer: 第14回日本心不全学会 学術集会
  • Place of Presentation: 東京
• [Presentation] TRPC6 is a novel therapeutic targetagainst pathological cardiac remodeling (2010)
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa他
  • Organizer: 0th World Congress of the InternationalSociety of Heart Research
  • Place of Presentation: Kyoto
• [Presentation] (2010)
  • Organizer: 20th European Meeting of Hypertension
  • Place of Presentation: Oslo, Norway
• [Presentation] Blockade of TRPC6 is a novel therapeuticapproach against pathological cardiachypertrophy (2010)
  • Author(s): Hideyuki Kinoshita, KoichiroKuwahara, Yasuaki Nakagawa,他
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Chicago, USA
• [Presentation] T-type Ca2+ channel blockade improvedsurvival and arrhythmogenicity in the mousemodel of myocardial infarction
  • Author(s): Yoshihiro Kuwabara, Koichiro Kuwahara,Yasuaki Nakagawa 他
• [Presentation] Essential role of p300 in maintainingmitochondrial gene expression and cell survivalin the postnatal heart
  • Author(s): Yasuaki Nakagawa
• [Presentation] N-Type Ca2+ Channel Blocker is Effective toPrevent Sudden CardiacDeath in Mice with Heart Failure
  • Author(s): Yuko Yamada, Koichiro Kuwahara,YasuakiNakagawa他
• [Presentation] Blockade of TRPC6 is a Novel TherapeuticApproach Against Pathological CardiacHypertrophy
  • Author(s): Hideyuki Kinoshita, KoichiroKuwahara Yasuaki Nakagawa他
• [Presentation] TRPC Ion Channels as Potentially NovelTherapeutic Targets for The Treatment ofPulmonary Arterial Hypertension
  • Author(s): HideyukiKinoshita, Koichiro Kuwahara, , YasuakiNakagawa, 他
• [Presentation] HCN channel inhibition with ivabradineprevents sudden arrhythmic death in a mousemodel of dilated cardiomyopathy.
  • Author(s): YoshihiroKuwabara, Koichiro Kuwahara, , YasuakiNakagawa , 他
• [Presentation] 受容体活性化型Ca2+チャネルTRPC3/6阻害の病的心肥大抑制効果
  • Author(s): 木下秀之、桑原宏一郎、清中茂樹、森泰生、西田基宏、黒瀬等、榮向路、李育浩、中川靖章、他
• [Presentation] ANP・BNP遺伝子発現調節因子NRSFの機能阻害による心筋症モデルマウスにおける不整脈発症・突然死に対するHCNチャネル阻害の効果
  • Author(s): 〓原佳宏,桑原宏一郎,中川靖章 他
• [Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Ca2+チャネル阻害の有用性の検討
  • Author(s): 山田優子、桑原宏一郎、中川靖章、他
  • Organizer: 第34回日本日本高血圧学会総会
  • Place of Presentation: 宇都宮、栃木
• [Presentation] ANP・BNP 遺伝子発現調節因子NRSFにより制御されるHCNチャネルの心不全モデルマウスにおける突然死発症への関与
  • Author(s): 〓原佳宏,桑原宏一郎,中川靖章,他
  • Organizer: 第15回日本心血管内分泌学会
  • Place of Presentation: 大阪
• [Presentation] 病的血管リモデリングでみられる血管平滑筋細胞形質転換におけるRho依存性転写共役因子MRTF-Aの意義
  • Author(s): 」南 丈也・桑原宏一郎・中川靖章 他
• [Presentation] BNP遺伝子発現調節領域におけるserumresponse factor 応答領域の新たなる同定とその心筋細胞肥大反応における意義
  • Author(s): 桑原宏一郎・木下秀之・〓原佳宏・中川靖章・他
• [Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Ca2+チャネル阻害の有用性の検討
  • Author(s): 山田優子、桑原宏一郎、木下秀之、桑原佳宏、中川靖章 他
• [Presentation] MRTF-A, a rho-dependent co-activator of SRF,plays a critical role in vascular remodeling byregulating smooth muscle cell migration
  • Author(s): Takeya Minami, Koichiro Kuwahara,YasuakiNakagawa 他
• [Presentation] 拡張型心筋症マウスにおけるN型Ca2+チャネル阻害による自律神経活性調節を介した不整脈突然死予防の有用性
  • Author(s): 山田優子、桑原宏一郎、中川靖章、他
• [Presentation] Reciprocal expression of MRTF-A andMyocardin is crucial for pathological vascularremodeling in mice
  • Author(s): Takeya Minami, KoichiroKuwahara, Yasuaki Nakagawa, 他
• [Presentation] Translational Repressor NRSF plays anessential role in maintaining normal cardiacstructure and function after birth
  • Author(s): YoshihiroKuwabara, Koichiro Kuwahara, YasuakiNakagawa 他
• [Presentation] Inhibition of REnin-angiotensin system stronglyprevents arrhythmogenic left ventricularremodeling and sudden cardiac death in micewith dilated cardiomyopathy
  • Author(s): Chinatsu Yamada,Koichiro Kuwahara, Yasuaki Nakagawa 他
• [Presentation] NRSF maintains normal cardiac structure andfunction
  • Author(s): Koichiro Kuwahara, YasuakiNakagawa他
• [Presentation] Inhibition of TRPC6 Channel Conributes to theAnti-hypertrophic Effects of NatriureticPeptides-Guanylyl Cyclase-A Signaling in theHeart
  • Author(s): Koichiro Kuwahara, Yasuaki Nakagawa他
• [Presentation] Blockade of T-Type Ca2+ Channel PreventsSudden Death in Mice With Heart Failure
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa他
• [Presentation] Effect of functional inhibition of p300 on themitochondrial function and cell survival in thepost-natal heart in mice
  • Author(s): Yasuaki Nakagawa
• [Presentation] Inhibition of TRPC6 Channel Contributes to theAnti-hypertrophic Effects Exerted by NatriureticPeptides-Guanylyl Cyclase-A Signaling in theHeart
  • Author(s): Koichiro Kuwahara, Yasuaki Nakagawa他
• [Presentation] Basic Cardiovascular Sciences 2010 ScientificSessions Jul 19-22,2010. Rancho Mirage, CA,USA Blockade of TRPC Channel PreventsPathological Cardiac Hypertrophy
  • Author(s): Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa他
• [Presentation] T-type Ca2+ Channel Blockade ImprovedCardiac Autonomic Nervous System Imbalanceand Reduced Sudden Death in Mice Model of Chronic Heart Failure
  • Author(s): Hideyuki Kinoshita,Koichiro Kuwahara, Yasuaki Nakagawa他
  • Organizer: European Society of Cardiology Congress2010Aug28-Sept.01. Stockholm, Sweden
• [Presentation] MRTF-A, a Rho-dependent coactivator of SRF,plays a critical role in vascular remodeling
  • Author(s): Takeya Minami, Koichiro Kuwahara, YasuakiNakagawa,他
• [Presentation] Blockade of TRPC6/3 is a Novel TherapeuticApproach for Preventing Pathological CardiacHypertrophy
  • Author(s): Hideyuki Kinoshita, KoichiroKuwahara, Yasuaki Nakagawa, 他
• [Presentation] Inhibition of HCN overexpressed in failingheart of dilated cardiomyopathy mouse model byivabradine prevents sudden arrhythmic death
  • Author(s): Yoshihiro Kuwabara, Koichiro Kuwahara, ,Yasuaki Nakagawa, 他
• [Presentation] N-Type Ca2+ Channel Blocker is Effective toPrevent Sudden Cardiac Death in Mice withHeart Failure
  • Author(s): Yuko Yamada, Koichiro Kuwahara, HideyukiKinoshita, Yoshihiro Kuwabara, YasuakiNakagawa, 他
• [Presentation] Induction of Myocardin-Related TranscriptionFactor-A Contributes to the PhenotypicAlteration of Vascular Smooth Muscle Cells andPlays a Pivotal Role in Vascular Remodeling
  • Author(s): Takeya Minami, Koichiro Kuwahara, YasuakiNakagawa, 他
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html
• [Remarks] 京都大学大学院医学研究科内分泌代謝内科ホームページ
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html