| Project/Area Number |
22590826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SUZUKI Yuko 浜松医科大学, 医学部, 准教授 (20345812)
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| Co-Investigator(Kenkyū-buntansha) |
URANO Tetsumei 浜松医科大学, 医学部, 教授 (50193967)
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 血管内皮細胞 / 線溶活性 / 可視化解析 / 組織プラスミノゲンアクチベータ / 組織型プラスミノゲンアクチベータ / プラスミノゲンアクチベータインヒビター１ / 内皮バリア機能 |
|---|
| Research Abstract |
Thrombolysis initiation factor , tPA, is secreted from the vascular endothelial cells as an active enzyme. Based on our previous study, in which we visualized the exocytotic dynamics of tPA, we clarified the expression and augmentation mechanisms of thrombolytic activity and the possibility to modulate the cellular function.
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