The role of opioid receptors-allergic immune responses axis in stress-induced asthma
| Project/Area Number |
22590843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
OHNO Isao 東北薬科大学, 薬学部, 教授 (00250762)
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| Co-Investigator(Kenkyū-buntansha) |
SORA Ichiro 東北大学, 医学系研究科, 教授 (40322713)
KIKUCHI Toshiaki 東北大学, 大学病院, 講師 (10280926)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURADA Shinobu 東北薬科大学, 薬学部, 教授 (30075816)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | アレルギー / 気管支喘息 / 精神的ストレス / μ-オピオイド受容体 / グルココルチコイド / Th2サイトカイン / 制御性T細胞 / Th２サイトカイン / μオピオイド受容体 |
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| Research Abstract |
Psychological stress has been well characterized as one of risk factors for asthma exacerbations. However, pathways linking the stress perceived in the central nervous system to asthma exacerbations still remain unclear. In this project, we analyzed mechanisms underlying stress-related asthma exacerbations using a murine model of stress-induced asthma exacerbations that we previously published. We demonstrated the involvement of μ-opioid receptors in the central nervous system and the increase of corticosterone levels in blood following the activation of the μ-opioid receptors in stress-related asthma exacerbations, and further skewing of antigen-specific immune responses to Th2 predominance associated with the failure of regulatory T cell development. These findings suggest the neuro-endocrino-immune axis as a possible pathway in stress-induced asthma exacerbations.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] CD4 and CD8 T cells require different membrane gangliosides for activation2012
Author(s)
Nagafuku M, Okuyama K, Onimaru Y, Suzuki A, Odagiri Y, Yamashita T, Iwasaki K, Fujiwara M, Takayanagi M, Ohno I, Inokuchi J
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Issue: 6
DOI
Related Report
Peer Reviewed
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