Investigations on development of pulmonary arterial intimal sarcoma and identification and isolation of hematopoietic stem cells
| Project/Area Number |
22590851
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Koichiro 千葉大学, 大学院・医学研究院, 教授 (10207061)
KASAHARA Yasunori 千葉大学, 医学部附属病院, 講師 (60343092)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
|---|
| Keywords | 非閉塞性肺疾患癌 / 肺動脈原発血管内肉腫 / 肺線維症 / 呼吸器感染症 |
|---|
| Research Abstract |
We have investigated sarcoma-like cells (SCLs) derived from endarterectomized tissue from chronic thromboembolic pulmonary hypertension (CTEPH). The characteristic features of SCLs showed that these cells appeared to be pulmonary arterial intimal sarcoma. Because of the increased expression of mRNAs of matrixmethalloproteinase (MMPs), anti-tumor effects of MMPs inhibitors (batimastat) were examined. Batimastat inhibited cell proliferation, invasion, migration, and tube-formation of SCLs. Moreover, batimastat inhibited the growth of subucutanenous tumor and weight loss of the mice. These results indicate that MMPs inhibitors seem to be effective against some types of intimal sarcoma. Previous study suggested that SCLs might include some kinds of hematopoietic stem cells, but isolation of these cells would be future directions.
|
Report
(4 results)
Research Products
(40 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Characterization of myofibroblasts in chronic thromboembolic pulmonary hypertension2011
Author(s)
Maruoka M, Sakao S, Kantake M, Tanabe N, Kasahara Y, Kurosu K, Takiguchi Y, Masuda M, Yoshino I, Voelkel NF, Tatsumi K
-
Journal Title
Int J Cardiol.
Volume: Mar 14(Epub ahead of print)
Related Report
Peer Reviewed
-
-
[Journal Article] Association of deep vein thrombosis type with clinical phenotype of chronic thromboembolic pulmonary hypertension2011
Author(s)
Kantake M, Tanabe N, Sugiura T, Shigeta A, Yanagawa N, Jujo T, Kawata N, Amano H, Matsuura Y, Nishimura R, Sekine A, Sakao S, Kasahara Y, Tatsumi K
-
Journal Title
Int J Cardiol.
Volume: Sep 17(Epub ahead of print)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Sekine A, Tanabe N, Sakao S, Nishimura R, Terada J, Sugiura T, Kasahara Y, Tatsumi K. Mixed venous oxygen tension affects the prognosis on pulmonary hypertension even in recent Era.2012
Author(s)
Sekine A, Tanabe N, Sakao S, Nishimura R, Terada J, Sugiura T, Kasahara Y, Tatsumi K.
Organizer
American Thoracic Society 2011 International Conference
Place of Presentation
San Francisco, USA
Related Report
-
[Presentation] Estimation of pulmonary arterial pressure in pulmonary hypertension based on interventricular septal configuration obtained by Electrocardiogram-gated 320 Slice CT2011
Author(s)
Sugiura T, Tanabe N, Kawata N, Matsuura Y, Yanagawa N, Jujyo T, Sekine A, Nishimura R, Amano H, Sakao S, Kasahara Y, Tatsumi K
Organizer
American Thoracic Society 2011 International Conference
Place of Presentation
DENVER, COLORADO, USA
Year and Date
2011-05-18
Related Report
-
-
[Presentation] G Protein Beta3 Subunit GNB3 C825T polymorphism affects the efficacy of Sildenafil on pulmonary hypertension2011
Author(s)
Sekine A, Tanabe N, Kitazono S, Kitazono M, Nishimura R, Takada Y, Jujo T, Sugiura T, Yasuda T, Sakao S, Kasahara Y, Takiguchi Y, Tatsumi K
Organizer
American Thoracic Society 2011 International Conference
Place of Presentation
DENVER, COLORADO, USA
Year and Date
2011-05-16
Related Report
-
-
-
