Establishment of immune complex-mediated disease models by human patient sera

• Project/Area Number: 22590885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: TSUBOI Naotake 名古屋大学, 医学部附属病院, 講師 (50566958)
• Co-Investigator(Kenkyū-buntansha): YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479) ; MARUYAMA Shoichi 名古屋大学, 大学院・医学系研究, 准教授 (10362253)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 好中球 / 全身性ループスエリテマトーデス / インテグリン / Fc 受容体 / Fc受容体 / 自己免疫疾患 / 免疫複合体 / Fcγ受容体

Research Abstract

In newly established animal model of lupus nephritis induced by passive transfer of human systemic lupus erhythematosus (SLE) sera, essential role of human FcγRIIA and protective role of Mac-1 for disease induction were elucidated. The Pristine-induced SLE model demonstrated dual roles of Mac-1 as promoting pulmonary hemorrhage and as protective against lupus nephritis.

Research Products

• [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. (2013)
  • Author(s): Katsuno T
  • Journal Title: Cell Transplant Volume: 22(2) Issue: 2 Pages: 287-97
  • DOI: 10.3727/096368912x655019
  • Peer Reviewed
• [Journal Article] Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by mac-1 deficiency (2012)
  • Author(s): Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Tsokos GC, Mayadas TN.
  • Journal Title: J Immuno Volume: 189(7) Pages: 3714-23
  • Peer Reviewed
• [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats (2012)
  • Author(s): Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Maruyama s.
  • Journal Title: Cell Transplant
  • Peer Reviewed
• [Journal Article] Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo (2012)
  • Author(s): Chen K,Tsuboi N, Mayadas TN.
  • Journal Title: Blood.
  • Peer Reviewed
• [Journal Article] Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites ofInflammation In Vivo (2012)
  • Author(s): Tsuboi N, Aikawa M, Newton G, Luscinskas FW.
  • Journal Title: J Immunol Volume: 189(5) Pages: 2553-62
  • Peer Reviewed
• [Journal Article] Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo. (2012)
  • Author(s): Chen K
  • Journal Title: Blood Volume: 120(22) Issue: 22 Pages: 4421-31
  • DOI: 10.1182/blood-2011-12-401133
  • Peer Reviewed
• [Journal Article] Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by mac-1 deficiency. (2012)
  • Author(s): Rosetti F
  • Journal Title: J Immunol Volume: 189(7) Pages: 3714-23
  • Peer Reviewed
• [Journal Article] Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites ofInflammation In Vivo. (2012)
  • Author(s): Tsuboi N
  • Journal Title: J Immunol Volume: 189(5) Issue: 5 Pages: 2553-62
  • DOI: 10.4049/jimmunol.1103606
  • Peer Reviewed
• [Journal Article] Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production (2011)
  • Author(s): Saka Y, Tsuboi N , Maruyama S
  • Journal Title: Xenotransplantation. Volume: 18(3) Pages: 196-208
  • Peer Reviewed
• [Journal Article] Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice (2011)
  • Author(s): Tsuboi N, Kohl J, Mayadas TN.
  • Journal Title: Arthritis Rheum. Volume: 63(2) Pages: 467-78
  • Peer Reviewed
• [Journal Article] Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin (2011)
  • Author(s): Kato K
  • Journal Title: Clin Exp Nephrol Volume: 15(3) Pages: 346-54
  • Peer Reviewed
• [Journal Article] A Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis (2011)
  • Author(s): Mizuno M
  • Journal Title: Intern Med Volume: 50(16) Pages: 1719-23
  • Peer Reviewed
• [Journal Article] Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice (2011)
  • Author(s): Tsuboi N
  • Journal Title: Arthritis Rheum Volume: 63(2) Pages: 467-78
  • Peer Reviewed
• [Journal Article] Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production (2011)
  • Author(s): Saka Y
  • Journal Title: Xenotransplantation Volume: 18(3) Pages: 196-208
  • Peer Reviewed
• [Journal Article] A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis (2011)
  • Author(s): Mizuno M
  • Journal Title: Intern Med Volume: 50(16) Pages: 1719-23
  • Peer Reviewed
• [Journal Article] A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis (2011)
  • Author(s): Suzuki Y
  • Journal Title: Clin Exp Nephrol Volume: 15(6) Pages: 962-5
  • Peer Reviewed
• [Journal Article] Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis (2011)
  • Author(s): Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S
  • Journal Title: Nephrol.Dial.Tranplant. Volume: 27(6) Issue: 6 Pages: 2511-6
  • DOI: 10.1093/ndt/gfr685
  • Peer Reviewed
• [Journal Article] Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. (2011)
  • Author(s): Kiyonari Kato
  • Journal Title: Clinical and Experimental Nephrol.ogy Volume: in press
  • Peer Reviewed
• [Journal Article] Human neutrophil FcγRIIA regulation by C5aR promotes inflammatory arthritis in mice. (2010)
  • Author(s): Naotake Tsuboi
  • Journal Title: Arthritis and rheumatism Volume: 63(2) Pages: 467-78
  • Peer Reviewed
• [Presentation] Serum Starved Adipose-Derived Stromal Cells Ameliorate Rat Crescentic Glomerulonephritis by Promoting the Generation of M2 Immunoregulatory Macrophages (2012)
  • Author(s): 古橋和拡
  • Organizer: 45rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Diego,USA
  • Year and Date: 2012-11-02
• [Presentation] ANCA 陽性急速進行性糸球体腎炎の透析導入後にヘパリン起因性血小板 減少症(HIT)を合併した 2 例 (2012)
  • Author(s): 坪井直毅
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2012-06-24
• [Presentation] LOW SERUM CULTURED ADIPOSE-DERIVED MESENCHYMAL STEM CELLS AMELIORATE CRESCENTIC GLOMERULONEPHRITIS BY FUNCTIONAL POLARIZATION OF MACROPHAGES INTO IMMUNOREGULATORY M2 PHENOTYPE (2012)
  • Author(s): 古橋和拡
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-13
• [Presentation] POTENTIAL OF ADIPOSE-DERIVED STEM CELLS FROM HUMAN/RAT/MOUSE AS A NEW TOOL FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (2012)
  • Author(s): 丸山彰一
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-13
• [Presentation] Mac-1 deficiency exacerbates glomerulonephritis in experimental model of systemic lupus erythematosus (2012)
  • Author(s): 石一沁
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-03
• [Presentation] ループス患者血清誘導性腎障害は好中球 Fcγ受容体 IIA により惹起されインテグリン Mac-1 欠損下で発症する (2012)
  • Author(s): 坪井直毅
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-02
• [Presentation] Mac-1 Deficiency Protects Mouse from Pulmonary Hemorrhage, Whereas Exacerbates Glomerulonephritis in Experimental Model of Systemic Lupus Erythematosus (2012)
  • Author(s): Shi Yiqin
  • Organizer: The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012(AP-VAS)
  • Place of Presentation: 東京
  • Year and Date: 2012-03-29
• [Presentation] Low Serum Cultured Adipose-derived Mesenchymal Stem Cells Ameliorate Crescentic Glomerulonephritis by Functional Polarization of Macrophages into Immunoregulatory M2 Phenotype (2012)
  • Author(s): 古橋和拡
  • Organizer: The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012(AP-VAS)
  • Place of Presentation: 東京
  • Year and Date: 2012-03-29
• [Presentation] Therapeutic Potential of Adipose-Derived Stem Cells for Anti-GBM Glomerulonephritis (2011)
  • Author(s): 古橋和拡
  • Organizer: 43rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Denver.co, USA
  • Year and Date: 2011-11-20
• [Presentation] Association of CD34+ Circulating Progenitor Cells and C-Reactive Protein with Cardiovascular and All-Cause Mortality in Hemodialysis Patients (2011)
  • Author(s): 丸山彰一
  • Organizer: 43rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Denver.co, USA
  • Year and Date: 2011-11-18
• [Presentation] Evaluation of Diverticular Diseases by Computed Tomography Is Useful for Selection of Peritoneal Dialysis Modality and Asymptomatic Diverticulosis Is Not a Risk Factor for Peritonitis (2011)
  • Author(s): Yasuhiko Ito
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-12
• [Presentation] Lymphangiogenesis Develops during Peritoneal Fibrosis in Peritoneal Dialysis Patients and Rat Peritonitis Model (2011)
  • Author(s): Hiroshi Kinashi
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-11
• [Presentation] Association of Adipokines with Cardiovascular Mortality in Patients on Hemodialysis (2011)
  • Author(s): 丸山彰一
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA,USA
  • Year and Date: 2011-11-10
• [Presentation] Low Serum Cultured Adipose-Derived Mesenchymal Stem Cells, but Not Bone-Marrow Derived Mesenchymal Stem Cells, Ameliorate Rat Crescentic Glomerulonephritis by Functional Polarization of Macrophages into Immunoregulatory Phenotype (2011)
  • Author(s): 古橋和拡
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA,USA
  • Year and Date: 2011-11-10
• [Presentation] Low Serum Cultured Adipose-Derived Mesenchymal Stem Cells, but Not Bone-Marrow Derived Mesenchymal Stem Cells, Ameliorate Rat Crescentic Glomerulonephritis by Functional Polarization of Macrophages into Immunoregulatory Phenotype (2011)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-10
• [Presentation] Prognostic Value of Geriatric Nutritional Risk Index for Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients on Chronic Hemodialysis (2011)
  • Author(s): Kaoru Yasuda
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-10
• [Presentation] Association of Adipokines with Cardiovascular Mortality in Patients on Hemodialysis (2011)
  • Author(s): Shoichi Maruyama
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-10
• [Presentation] Low Serum Cultured Adipose Derived Stem Cells Ameliorate Zymosan Induced Severe Rat Peritonitis Model (2011)
  • Author(s): Hangsoo Kim
  • Organizer: 44rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-10
• [Presentation] 慢性腎臓病患者におけるHMG-CoA還元酵素阻害薬(ピタバスタチン)の腎機能に及ぼす影響の検討(P-STAR-CKD) (2011)
  • Author(s): 安田宜成
  • Organizer: 第41回日本腎臓学会西部学術総会
  • Place of Presentation: 徳島(徳島県郷土文化会館)
  • Year and Date: 2011-10-01
• [Presentation] 組織学的に診断された重度腎孟腎炎合併移植腎の1症例 (2011)
  • Author(s): 伊藤裕紀子
  • Organizer: 第41回日本腎臓学会西部学術総会
  • Place of Presentation: 徳島(徳島県郷土文化会館)
  • Year and Date: 2011-10-01
• [Presentation] 糸球体病変を欠くANCA関連腎炎の2症例 (2011)
  • Author(s): 野中慶佑
  • Organizer: 第41回日本腎臓学会西部学術総会
  • Place of Presentation: 徳島(徳島県郷土文化会館)
  • Year and Date: 2011-10-01
• [Presentation] Low serum cultured adipose-derived mesenchymal stromal cells, but not bone-marrow derived mesenchymal stem cells, ameliorate rat crescentic glomerulonephritis by functional polarization of macrophages into immunoregulatory M2 phenotype (2011)
  • Author(s): 古橋和拡
  • Organizer: 5th International Conference on Autoimmunity: Mechanisms and Novel Treatments
  • Place of Presentation: ギリシャ
  • Year and Date: 2011-09-23
• [Presentation] 脂肪由来間葉系幹細胞を用いた壊死性半月体形成腎炎への新たな治 療法の確立～骨髄由来間葉系細胞にはなく塩脂肪由来幹細胞がもつMacrophage への unique chaqracter～ (2011)
  • Author(s): 古橋和拡
  • Organizer: 第三回腎疾患と高血圧研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-27
• [Presentation] 脂肪由来間葉系幹細胞を用いた壊死性半月体形成腎炎への新たな治療法の確立～骨髄由来間葉系細胞にはなく塩脂肪由来幹細胞がもつMacrophageへのunique chaqracter～ (2011)
  • Author(s): 古橋和拡
  • Organizer: 第三回腎疾患と高血圧研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-27
• [Presentation] 多肢趾壊死を伴ったコレステロール塞栓症による腎不全に対して腹膜透析を選択した一例 (2011)
  • Author(s): 早崎貴洋
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-18
• [Presentation] 異物によるS状結腸穿孔から汎発性腹膜炎をきたしたCAPD患者の一例 (2011)
  • Author(s): 中島諒子
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-18
• [Presentation] 脂肪由来間葉系幹細胞を用いた難治性腎疾患への新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] Zymosanによる高度炎症の腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞(LASC)の効果 (2011)
  • Author(s): 金恒秀
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 腹膜透析における小、中、大分子量物質除法と腹膜機能の関連性 (2011)
  • Author(s): 平松英樹
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] Oxaliplatinにより自己免疫性溶血性貧血・血小板減少を伴うAKIを来した1例 (2011)
  • Author(s): 伊藤功
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 疣贅PCRによりStaphylococcus warneriを起因菌と同定できた感染性心内膜炎の1例 (2011)
  • Author(s): 伊藤功
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 脂肪細胞由来幹細胞は腎臓をどう守るのか (2011)
  • Author(s): 丸山彰一
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-15
• [Presentation] IgA患者におけるPozziらのステロイドパルス療法の有効性 (2011)
  • Author(s): 立松美穂
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-15
• [Presentation] 脂肪由来間葉系幹細胞(ASC)を用いた難治性腎疾患・自己免疫疾患に対する新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-02
• [Presentation] 脂肪由来間葉系幹細胞(ASC)を用いた難治性腎疾患・自己免疫疾患に対する新たな治療戦略 (2011)
  • Author(s): 古橋和拡
  • Organizer: 再生医療学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2011-03-02
• [Presentation] Low serum cultured adipose-derived mesenchymal stromal cells, but not bone-marrow derived mesenchymal stem cells, ameliorate rat crescentic glomerulonephritis by functional polarization of macrophages into immunoregulatory M2 phenotype (2011)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: 5th International Conference on Autoimmunity : Mechanisms and Novel Treatments
  • Place of Presentation: ギリシャ
• [Presentation] Therapeutic Potential of Adipose-Derived Stem Cells for Anti-GBM Glomerulonephritis (2010)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center, Denver, CO, U.S.A.
  • Year and Date: 2010-11-20
• [Presentation] Knock-Down of HGF and VEGF Production Reduces the Renoprotective Effects of Adipose-Derived Stromal Cells in the Acute Kidney Injury (2010)
  • Author(s): Takayuki Katsuno
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center, Denver, CO, U.S.A.
  • Year and Date: 2010-11-19
• [Presentation] Association of CD34+ Circulating Progenitor Cells and C-Reactive Prote in with Cardiovascular and All-Cause Mortality in Hemodialysis Patients (2010)
  • Author(s): Shoichi Maruyama
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center, Denver, CO, U.S.A.
  • Year and Date: 2010-11-18
• [Presentation] Peritoneal Macrophage Infiltration Is Correlated with Baseline Peritoneal Solute Transport Rate in Peritoneal Dialysis Patients (2010)
  • Author(s): Akiho Sawai
  • Organizer: 42rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Colorado Convention Center, Denver, CO, U.S.A.
  • Year and Date: 2010-11-18
• [Presentation] リツキシマブが有効であったクリオグロブリン血症の一例 (2010)
  • Author(s): 早崎貴洋
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-09
• [Presentation] Primary roles of human neutrophil Fc gamma receptors in vivo (2010)
  • Author(s): 坪井直毅
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-09
• [Presentation] VEGF receptor2特異的結合性VEGF-Aの強発現は腎障害を引き起こす (2010)
  • Author(s): 小杉智規
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-08
• [Presentation] クリオグロブリン血症を伴いゲムシタビン誘発TMAをきたした一例 (2010)
  • Author(s): 立松美穂
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-08
• [Presentation] Tuener症候群と馬蹄腎の患者に合併した抗基底膜抗体型腎炎の一例 (2010)
  • Author(s): 佐藤和一
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-10-08
• [Presentation] Primary roles of human neutrophil Fc gamma receptors in vivo (2010)
  • Author(s): 坪井 直毅
  • Organizer: 第40回日本腎臓学会東部学術大会
  • Place of Presentation: 広島
  • Year and Date: 2010-08-09
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞を用いた骨粗鬆症モデルマウスに対する治療効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] Primary role for human neutrophil FcgRIIA and C5aR in the development of inflammatory rheumatoidarthritis (2010)
  • Author(s): 坪井直毅
  • Organizer: 7th International Conference on Innate Immunity
  • Place of Presentation: ギリシャ
  • Year and Date: 2010-07-04
• [Presentation] Therapeutic potential of adipose-derived stem cells for anti-GBM glomerulonephritis (2010)
  • Author(s): 古橋和拡
  • Organizer: 7th International Conference on Innate Immunity
  • Place of Presentation: ギリシャ
  • Year and Date: 2010-07-04
• [Presentation] Therapeutic potential of adipose-derived stem cells for anti-GBM glomerulonephritis (2010)
  • Author(s): Kazuhiro Furuhashi
  • Organizer: 7th International Conference on Innate Immunity
  • Place of Presentation: Sheraton Rhodes, Rhodes, Greece
  • Year and Date: 2010-07-04
• [Presentation] Primary role for human neutrophil FcgRIIA and C5aR in the development of inflammatory rheumatoidarthritis (2010)
  • Author(s): Naotake Tsuboi
  • Organizer: 7th International Conference on Innate Immunity
  • Place of Presentation: Sheraton Rhodes, Rhodes, Greece
  • Year and Date: 2010-07-04
• [Presentation] 急速な病勢増悪を認めたα streptococcusによるCAPD腹膜炎の一例 (2010)
  • Author(s): 増田智広
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-06-19
• [Presentation] rHuEPOによる赤血球造血刺激因子製剤(ESA)療法低反応性腹膜透析(PD)患者のDarbepoetin α(DA)の効果 (2010)
  • Author(s): 平松英樹
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-06-18
• [Presentation] 慢性透析患者におけるCD34陽性細胞数の減少は心血管予後不良予測因子である～4年間の前向きコホート研究～ (2010)
  • Author(s): 丸山彰一
  • Organizer: 第55回日本透析医学会学術集会
  • Place of Presentation: 神戸商工会議所会館
  • Year and Date: 2010-06-18
• [Presentation] 脂肪由来間葉系幹細胞による Goodpastue disease モデルへの治療効果の検討 (2010)
  • Author(s): 古橋 和拡
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 超音波造影剤を用いた腎血流と腎機能との関連の検討 (2010)
  • Author(s): 尾崎武徳
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場・神戸ポートピアホテル・神戸国際展示場
  • Year and Date: 2010-06-17
• [Presentation] 脂肪由来間葉系幹細胞によるGoodpastue diseaseモデルへの治療効果の検討 (2010)
  • Author(s): 古橋和拡
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場・神戸ポートピアホテル・神戸国際展示場
  • Year and Date: 2010-06-17
• [Presentation] RENOPROTECTIVE EFFECTS AND MECHANISMS OF HUMAN ADIPOSE TISSUE-DERIVED S TROMALCELLS CULTURED IN LOW SERUM MEDIA ON ACUTE KIDNEY INJURY. (2010)
  • Author(s): Takayuki Katsuno
  • Organizer: APCN 2010
  • Place of Presentation: Convention and Exhibition Center (COEX), Seoul, Korea
  • Year and Date: 2010-06-06
• [Presentation] Primary role for human neutrophil Fcγ〔gamma〕RIIA and C5aR in the development of inflammatory rheumatoid arthritis (2010)
  • Author(s): 坪井直毅
  • Organizer: Experimental Biology2010
  • Place of Presentation: California,USA
  • Year and Date: 2010-04-27
• [Presentation] Primary role for human neutrophil Fcγ 〔gamma〕 RIIA and C5aR in the development of inflammatory rheumatoid arthritis. (2010)
  • Author(s): Naotake Tsuboi
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim Convention Center, Anaheim, CA, U.S.A.
  • Year and Date: 2010-04-27
• [Presentation] Adipose-derived mesenchymal stem cells suppress antibody production against graft antigens (2010)
  • Author(s): Yosuke-Saka
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] Renoprotective effects of human adiposetissue-derived stromal cells cultured in low serum media on acute kidney injury (2010)
  • Author(s): Takayuki Katsuno
  • Organizer: ISN nexus
  • Place of Presentation: 京都国際会議センター(ICC京都府)
  • Year and Date: 2010-04-17
• [Presentation] 脂肪由来間葉系細胞による移植抗原に対する抗体産生抑制効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] Therapeutic Potential of Adipose-Derived Stem CellS for anti-GBM Glomerulone phritis (2010)
  • Author(s): 古橋和拡
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] 腎再生療法における低血清培養脂肪組織由来間葉系細胞の有用性 (2010)
  • Author(s): 勝野敬之
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞を用いた骨粗霧症モデルマウスに対する治療効果 (2010)
  • Author(s): 丸山彰一
  • Organizer: 第31回日本炎症・再生学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] NCA陽性急速進行性糸球体腎炎の透析導入後にヘパリン起因性血小板減少症(HIT)を合併した2例
  • Author(s): 坪井直毅
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] ループス患者血清誘導性腎障害は好中球Fcγ受容体IIAにより惹起されインテグリンMac-1欠損下で発症する
  • Author(s): 坪井直毅
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Serum Starved Adipose-Derived Stromal Cells Ameliorate Rat Crescentic Glomerulonephritis by Promoting the Generation of M2 Immunoregulatory Macrophages
  • Author(s): 古橋和拡
  • Organizer: 45rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: USA
• [Patent(Industrial Property Rights)] 脂肪組織由来間葉系肝細胞を含有する免疫抑制剤及びその用途 (2012)
  • Inventor(s): 丸山彰一、尾崎武徳、坂洋祐、古橋和拡、坪井直毅
  • Industrial Property Rights Holder: 名古屋大学
  • Acquisition Date: 2012-02-17